Ultrathin Films of Polypyrrole Derivatives for Dopamine Detection

Fabregat, Georgina; Córdova-Mateo, Esther; Armelín, Elaine; Bertrán, Oscar; Alemán, Carlos

doi:10.1021/jp203898r

Cited by 59 publications

(88 citation statements)

References 46 publications

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“…These electrodes provide separation of the peak potentials and, additionally, present peak currents high enough for unambiguous detection. In contrast, electrodes based on 1-PNMPy and 1-PNCPy, which were found to be very effective for the detection of DA in solutions without interferents, 18,19 show important disadvantages for the selective determination of DA in real biological fluids.…”

Section: Resultsmentioning

confidence: 97%

“…solution without interferents). 18,19 The electrocatalytic activity imparted by AuNPs to these electrodes should be attributed to their well-known ability for channeling electrons between the electrode and the electroactive species, promoting better electron transfer between the electrode and the electrolyte. 39 Thus, AuNPs facilitate the effective charge migration through the 1-PNMPy films by generating many active sites inside this CP-electrode.…”

Section: Resultsmentioning

confidence: 99%

“…Results indicated that C-HÁ Á ÁO non-conventional hydrogen bonds are responsible for the interaction between DQ molecules and these two PPy derivatives play a crucial role in the detection process. 19 In order to examine the molecular affinity of PEDOT towards DA, AA and UA, quantum mechanical calculations have been used to examine the chemical nature and strength of intermolecular interactions in n-EDOTÁ Á ÁX complexes with X = DQ, dAA and qdU. A build-up scheme, similar to that previously used to model n-NMPyÁ Á ÁDQ and n-NCPyÁ Á ÁDQ complexes, 19 has been applied for such a purpose.…”

Section: Resultsmentioning

confidence: 99%

“…18,19 More specifically, poly(N-methylpyrrole) and poly(N-cyanoethylpyrrole), hereafter denoted PNMPy and PNCPy, respectively, deposited on glassy carbon electrodes were found to be highly sensitive to the DA concentration, presenting a very fast response even when the concentration of neurotransmitter is very low. 18,19 Furthermore, such response was enhanced by adding gold nanoparticles (AuNPs) to PNMPy or PCNPy films (i.e. forming PNMPy/AuNP and PNCPy/AuNP composites), even though metallic nanoparticles were not essential for the sensing a Departament d'Enginyeria Química, E. T. S. d'Enginyers Industrials, abilities of such CPs.…”

mentioning

confidence: 99%

“…Results have been compared with those reported for PNMPy and PNCPy. 19 Overall of the results has been used to improve the selectivity and sensitivity of PEDOT by engineering some chemical modifications essentially oriented to enhance the binding between the CP and the analytes. Experimental development of such rational design has allowed us to identify a CP that has been proved to show optimized selectivity and sensitivity for the separation of DA, AA and UA in tertiary mixtures.…”

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confidence: 99%

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A rational design for the selective detection of dopamine using conducting polymers

Fabregat

Casanovas

Redondo

et al. 2014

Phys. Chem. Chem. Phys.

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Poly(N-methylpyrrole) (PNMPy), poly(N-cyanoethylpyrrole) (PNCPy) and poly(3,4-ethylenedioxythiophene) (PEDOT) films have been prepared using both single and two polymerization steps for the selective determination of low concentrations of dopamine, ascorbic acid and uric acid in tertiary mixtures.Analysis of the sensitivity and resolution parameters derived from the electrochemical response of such films indicates that PEDOT is the most appropriate for the unambiguous detection of the three species.Indeed, the performance of PEDOT is practically independent of the presence of both gold nanoparticles at the surface of the film and interphases inside the film, even though these two factors are known to improve the electroactivity of conducting polymers. Quantum mechanical calculations on model complexes have been used to examine the intermolecular interaction involved in complexes formed by PEDOT chains and oxidized dopamine, ascorbic acid and uric acid. Results show that such complexes are mainly stabilized by C-HÁ Á ÁO interactions rather than by conventional hydrogen bonds.In order to improve the sensitivity of PEDOT through the formation of specific hydrogen bonds, a derivative bearing a hydroxymethyl group attached to the dioxane ring of each repeat unit has been designed. Poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PHMeDOT) has been prepared and characterized by FTIR, UV-vis spectroscopy, cyclic voltammetry, scanning electron microscopy and atomic force microscopy. Finally, the performance of PHMeDOT and PEDOT for the selective detection of the species mentioned above has been compared.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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A rational design for the selective detection of dopamine using conducting polymers

Fabregat

Casanovas

Redondo

et al. 2014

Phys. Chem. Chem. Phys.

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Dual‐Functionalization Device for Therapy through Dopamine Release and Monitoring

Fabregat

Giménez

Díaz

et al. 2018

Macromolecular Bioscience

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A dual‐functional device is fabricated to release progressively dopamine (DA) from a biohydrogel under real‐time monitoring via electrochemical detection. For this purpose, a poly‐γ‐glutamic acid biohydrogel is assembled with a poly(3,4‐ethylenedioxythiophene) (PEDOT) layer, previously deposited onto a screen printed electrode. The biohydrogel is formulated to achieve dimensional stability and maximum DA‐loading capacity. Conditions for DA‐loading are influenced by the oxidation of the neurotransmitter in acid environments and the poor resistance of PEDOT to the lyophilization. The performance of the device is proved in a medium with the physiological pH of blood and the cerebrospinal fluid. The progressive release of DA is successfully monitored by the device, the limit of detection and sensitivity of the integrated sensor being 450 × 10−9m and 8 × 10−5 mA µm−1, respectively. The effect of electrochemical stimulation in the kinetics of the DA release is also investigated applying potential ramps in cyclic phase to alter the biohydrogel morphology.

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Progress in electrochemical detection of neurotransmitters using carbon nanotubes/nanocomposite based materials: A chronological review

et al. 2020

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Neurotransmitters (NTs) are chemical compounds that play an important physiological role in the functioning of central nervous, renal, hormonal, and cardiovascular systems. Their function is to regulate neural interactions by reducing the permeability of gap junctions between adjacent neurons of the same type. The abnormal level may lead to diseases, such as Parkinson's disease, Huntington's disease, Alzheimer's diseases, and other neurological diseases. The devastating health hazards associated with the abnormal presence of NTs in biological systems coupled with the demerits of most modern detection methods necessitates the continuous development of novel electrochemical sensors. Carbon nanotube (CNT)-based sensors, as a result of the large surface area, biocompatibility, and chemical stability supplied by CNTs, have proven to offer massive sensitivity and low limit of detection (LOD). Its significance in sensors applications toward the detection of different group of compounds cannot be overemphasized. There are several review articles on NTs and their determination using different chemically modified electrodes and sensor platform. However, this review highlights the significance of notable NTs and the progress made in the last decade in the design of CNT-based sensors for the detection of common NTs. Secondly, the This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ultrathin Films of Polypyrrole Derivatives for Dopamine Detection

Cited by 59 publications

References 46 publications

A rational design for the selective detection of dopamine using conducting polymers

A rational design for the selective detection of dopamine using conducting polymers

Dual‐Functionalization Device for Therapy through Dopamine Release and Monitoring

Progress in electrochemical detection of neurotransmitters using carbon nanotubes/nanocomposite based materials: A chronological review

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