Ultrastrukturelle Untersuchungen bei chronischer Rhinosinusitis ohne Polypen

Thiele, Alexander; Holzhausen, H.-J.; Riederer, A.; Knipping, S.

doi:10.1055/s-0030-1249022

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Studies have found impaired extracellular matrix production in nasal polyp tissue; this phenomenon is associated with the presence of a lower amount of collagen fibers in nasal polypoid tissues in comparison to the number in a healthy nasal mucosa [5,39,40]. Our study demonstrated that the nasal polyp-derived fibroblast morphology is also modified in this condition.…”

Section: Discussionsupporting

confidence: 54%

Alterations in cellular force parameters and cell projections in Nasal polyps-derived fibroblasts

et al. 2020

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Section: Discussionsupporting

confidence: 54%

Alterations in cellular force parameters and cell projections in Nasal polyps-derived fibroblasts

et al. 2020

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“…This latter cell type then synthesizes extracellular matrix proteins [5,6]. Adequate TGF-β1, primarily in its inactive form, is stored in the extracellular matrix, but must experience an activation phase before exerting its effects [7,8].…”

Section: Introductionmentioning

confidence: 99%

Regulation of Transforming Growth Factor-β1 Activation and Expression in the Tissue Remodeling Involved in Chronic Rhinosinusitis

Kou

Yao

et al. 2012

ORL

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Transforming growth factor-β1 (TGF-β1) plays a key role in the tissue remodeling processes involved in chronic rhinosinusitis (CRS), with the biological functions of secreted TGF-β1 regulated by multiple proteins. Among these regulators, latency-associated peptide and latent TGF-β-binding protein inhibit TGF-β1 function, whereas different proteases and integrins activate it. Progress in understanding the factors responsible for the bioactivity and expression of TGF-β1 has revealed that the dysregulation of TGF-β1 activation and expression is closely associated with the chronic respiratory inflammatory diseases involved in CRS. This review of the regulation of TGF-β1 activation and expression provides insight into the mechanism responsible for the different CRS subtypes, which will help further the investigation of novel therapy targets for the treatment of CRS.

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Does mucosal remodeling in chronic rhinosinusitis result in irreversible mucosal disease?

2011

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Mucosal remodeling in the sinuses is a recently described phenomenon in which the mucosa undergoes potentially irreversible changes as a result of ongoing underlying inflammatory processes. Research into remodeling that occurs in the bronchial airways in asthmatic patients has led to modification of asthma treatment guidelines. However, remodeling in the sinuses has still not led to changes in current medical or surgical management of chronic rhinosinusitis. Upper airway remodeling constitutes a new area of research that poses many unanswered clinical questions and may potentially alter the management of patients with severe chronic rhinosinusitis.

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Ultrastrukturelle Untersuchungen bei chronischer Rhinosinusitis ohne Polypen

Abstract: The study revealed the presence of evident ultrastructural changes in the mucosa of patients with chronic rhinosinusitis without nasal polyps. Mucosal remodeling seems to be not reversible by conservative treatment.

Cited by 7 publications

References 20 publications

Alterations in cellular force parameters and cell projections in Nasal polyps-derived fibroblasts

Alterations in cellular force parameters and cell projections in Nasal polyps-derived fibroblasts

Regulation of Transforming Growth Factor-β1 Activation and Expression in the Tissue Remodeling Involved in Chronic Rhinosinusitis

Does mucosal remodeling in chronic rhinosinusitis result in irreversible mucosal disease?

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