Ultrastructure of articular cartilage

Zelander, T.

doi:10.1007/bf00342718

Cited by 45 publications

(14 citation statements)

References 24 publications

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“…Transmission and scanning electron microscopic studies of human (18,22,24,(53)(54)(55), guinea pig (26), mouse (23,56,57), and rabbit (17,19) articular cartilage have confirmed this pattern ( Figures 4A, 4B, and 5). I n the immediate vicinity of cells, collagen fibrils sweep in capsular fashion about the lacunae ( Figure 5).…”

Section: Diagram Of the Fibrous Architecture Of Human Articular Cartimentioning

confidence: 65%

“…T h e diameter of the microfibrillar unit in articular cartilage varies with the species, the age of the individual, and the depth of cartilage. In general these collagen fibril diameters vary from 10 nm to over 100 nm (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). T h e typical banded pattern associated with collagen microfibrils results from the quarter stagger of the individual collagen molecules.…”

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confidence: 99%

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Review of articular cartilage collagen research

Lane

Weiss

1975

Arthritis & Rheumatism

145

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Recent advances in collagen methodology have now permitted a detailed investigation of this major structural protein of articular cartilage. Collagen structure, metabolism, antl morphology have been extensively studied in "soft" connective tissues (1,Z). Tlie difficulty of collagen extraction from cartilage and bone has prevented its characterization in "hard" connective tissues until recently (3). Since September 3, 1974; accepted May 5, 1975. in the rapidly progressing field of articular cartilage collagen research.Articular cartilage is a highly specialized connective tissue consisting of relatively small numbers of cells distributed throughout abundant extracellular matrix. T h e biophysical properties of articular cartilage that allow joints to serve as bearings in locomotion are in part related to tlie unique composition of tlie extracellular matrix. Collagen constitutes approximately 10% of the wet and 50y0 of the dry weight of cartilage (5). Noncollagenous material constitutes approximately the other 507, of the dry mass of articular cartilage matrix, of which the bulk is in the form of heterogenous proteoglycan complexes (6). Rather than being a single compound, the proteoglycans comprise multiple compounds that differ from each other in their sulfate content, amino acicl sequence of the peptide core, glycosaminoglycan composition, and side chain length.T h e biomaterial properties of the cartilage are a consequence of the interaction of the collagen and proteoglycans in the extracellular matrix. T h e chain extensions of the proteoglycans antl the electrostatic charges provide the molecular basis for consequent mechanical matrix stiffness (7). Tlie inability of the sulfate moieties to diffuse away from the glycosaminoglycan side chains influences the partition of water and diffusible electrolytes (8,9). T h e interaction of the proteoglycan with collagen is necessary for them to behave like gels (7). Whether the interaction is chem-

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Section: Diagram Of the Fibrous Architecture Of Human Articular Cartimentioning

confidence: 65%

mentioning

confidence: 99%

Review of articular cartilage collagen research

Lane

Weiss

1975

Arthritis & Rheumatism

145

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“…The chondrocytes in one capsule do not contact each other closely either, they are generally separated by a layer of perinuclear matrix of different thickness. Such an arrangement of the cellular component in the deep layer of the joint cartilage is characteristic for all types of hitherto investigated mammals including man (Zelander 1959;Godman and Porter 1960;Barnett et al 1961Barnett et al , 1963Ghadially and Roy 1961;Silberger et a1. 1961;Davies et al 1962;Fawcett 1966a;Palfrey and Davies 1966;Meachim 1967Schubert 1967;Stockwell 1966Stockwell , 1967a1971b, c;Toner and Carr 1968;Silberger 1968;Weiss et al 1968;Brower and Hsu 1969;Roy 1969, Meachim andRoy 1969;Ghadially et al 1970;Mitchell and Shepard 1970;Hirohata and Morimoto 1971;Weiss and Mirrow 1972;Meachim and Stockwell 1973;Stockwell and Meachim 1973;Dearden et al 1974;Refior 1974;Serafini-Fracassini and Smith 1974;Silberger andHasler 1974, 1975;Foldes 1975;Meachim and Fergie 1975;Hanaoka 1976;Schumacher 1976;Vignon et al 1976), and others.…”

Section: Deep Layermentioning

confidence: 94%

“…A number of authors dealt with the description of submicroscopic structure of joint cartilage; principal studies dealing with human cartilage were published by Zelander (1959), Godman et al (1960), Fawcett (1966a), Meachim (1967), Stockwell (1967a), Silberger (1968), Weiss et al (1968). Brower and Hsu (1969), Ghadially and Roy (1969), , Meachim and Roy (1969), Hirohata and Morimoto (1971), Stockwell and Meachim (1973), Serafini-Fracassini and Smith (1974), and others.…”

Section: Ultrastructure Hip Joint Cartilage Chondrocytes Intercellmentioning

confidence: 99%

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Submicroscopic Structure of the Human Joint Cartilage

Horký¹

1980

Acta Vet. Brno

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H 0 r k yD.: Submicroscopic Structure of the Human Joint Cartilage. Acta vet. Brno, 49, 1980: 145-176.Using a transmission and scanning electron microscope the joint cartilage was studied in 43 persons of the age from 5 to 75 years. As far as possible the present study gives a finished survey of the ultrastructure of chondrocytes of the superficial, middle and deep layers of the articular cartilage, arrangement of the intercellular substance; presented are basic data on the formation of the surface of the cartilage with regard to the age of the object. Special attention is given to cartilage intercellular substance which -from the point of view of electron microscopy -has been studied only little. The components of intercellular substance are arranged in such a way that we can distinguish the specialized areas near the chondrocytes as the pericellular matrix on the one hand, and the other intercellular substance, the intercellular matrix, on the other. The surface of the cartilage is covered with a specialized layer designated as lamina splendens. Results of the study proper are confronted with published data not only with regard to human joint cartilage but data on these structures have been studied also in lower mammals as much knowledge holds generally true for this type of tissue. The study summarizes the known facts about joint cartilage and provides a necessary basis for judging the degrees of changes occurring during some of their injuries. Ultrastructure, hip joint cartilage, chondrocytes, intercellular matrix, SEM.A number of authors dealt with the description of submicroscopic structure of joint cartilage; principal studies dealing with human cartilage were published by Zelander (1959), Godman et al. (1960), Fawcett (1966a), Meachim (1967), Stockwell (1967a), Silberger (1968, Weiss et al. (1968). Brower and Hsu (1969), Roy (1969), Meachim (1969), Meachim and Roy (1969), Hirohata and Morimoto (1971), Stockwell andMeachim (1973), Serafini-Fracassini and Smith (1974), and others. The present study gives the most possible finished survey about the ultrastructure of both the chondrocytes of the joint cartilage and the intercellular substance; given are also basic data on the formation of its surface in dependence on the age of the object. Results of our study are confronted with published data not only with regard to human joint cartilage but also to data on lower mammals as much knowledge holds generally true for this type of tissue. This fact has been proved in studies published by Barnett et al.

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