Ultrastructural Study of Hemangiomas

Kojimahara, Masayasu; Yamazaki, Keiji; Ooneda, Genju

doi:10.1111/j.1440-1827.1981.tb00989.x

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Caveolin-1 remains overexpressed in the endothelial cells of the capillary tufts at the edge of the hemangioma but is reduced in the sclerosed hyaluronic lesion (Figure 6a and b). Hemangioma has been reported to be composed of numerous caves forming a labyrinth with narrow interconnecting canals and lined by spindle-shaped endothelial cells with multilayered smooth muscle cells [21,22]. We demonstrated endothelial cells together with multilayered smooth muscle cells by electron microscopy and the difference between high expression of caveolin-1 in the endothelial cells and scanty expression of fibroblasts by immunohistochemistry.…”

Section: Discussionmentioning

confidence: 75%

A hepatic sclerosed hemangioma with significant morphological change over a period of 10 years: a case report

et al. 2013

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IntroductionLiver cavernous hemangioma is the most common noncystic hepatic lesion, and a hemangioma that undergoes degeneration and fibrous replacement is called a hepatic sclerosed hemangioma.Case presentationA 63-year-old Japanese man was admitted for detailed investigation of a liver tumor. Tumor markers carcinoembryonic antigen, alpha-fetoprotein, and CA19-9 levels in the peripheral blood were not elevated at any time. Plain computed tomography showed an approximately 1.5cm low density mass in the periphery of segment 8, which was marginally enhanced on contrast-enhanced dynamic computed tomography. On magnetic resonance imaging, the tumor was hypointense on T1-weighted image and hyperintense on T2-weighted image. The tumor was suspected to be an atypical hemangioma, metastatic, hepatocellular carcinoma, or cholangiocellular carcinoma. Segmental hepatectomy was performed. Histological examination of the resected tumor specimen revealed a sclerosed hemangioma with marked hyalinization and sparse stromal fibrosis. Immunochemically, the tumor cells were positive for CD34 and alpha smooth muscle actin. Electron microscopically, the residual hemangioma consisted of numerous caveolae and vesicles in endothelial cells in irregular shapes and sizes. Immunostaining for caveolin-1 showed decreased or no caveolin-1 reactivity in the hyalinized lesions of the sclerosed hemangioma, but abundant caveolin-1 reactivity in the residual cavernous hemangioma. Of interest, computed tomography images of the tumor obtained 10 years earlier at our hospital depicted a 3cm typical cavernous hemangioma.ConclusionsHepatic sclerosed hemangioma is a rare condition. Comparison of radiological findings of the lesion over a period of 10 years was valuable in providing insight for the evolutional process from liver cavernous hemangioma to hepatic sclerosed hemangioma.

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Section: Discussionmentioning

confidence: 75%

A hepatic sclerosed hemangioma with significant morphological change over a period of 10 years: a case report

et al. 2013

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“…The pathology of the adult form has some hamartomatous features [8]. It may be associated with hepatic focal nodular hyperplasia and an increase in size may occur during pregnancy or following estrogen administration [9,10].…”

Section: Adult Cavernous Hemangiomamentioning

confidence: 99%

“…Furthermore, in 1 report, 9 patients had lesions which were considered to be either technically unresectable or resectable only with unjustifiable risk. These were treated conservatively and none came to any harm [8]. Although steroids have been used to treat the infantile type of lesion mentioned above, there is no controlled evidence that these are of any value and there is no evidence at ail that they have any effect in adults.…”

Section: Managementmentioning

confidence: 99%

Hepatic hemangiomas

Hobbs

1990

World j. surg.

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There are 2 main and different forms of hepatic hemangiomas--those of early childhood and those of later adult life. The former, called infantile hepatic hemangioendothelioma, may be life-threatening due to arteriovenous shunting in extensive lesions resulting in cardiac failure. Although they may resolve spontaneously, if cardiac failure develops, they must be treated aggressively by arterial ligation or embolization. The adult form rarely gives rise to symptoms and should be left alone. Spontaneous rupture is extremely rare but may follow needle biopsy and it is in this group of patients that the occasional death has been reported. Biopsy should, therefore, be avoided. Symptomatic lesions should be resected in a specialized center where the morbidity and mortality of liver resection is acceptably very low.

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Ultrastructural Study of Hemangiomas

Kojimahara

Koyama

Igari

et al. 1981

Acta Pathologica Japonica

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A case of benign hemangioendothelioma which occurred in the hard palate was observed and its electron microscopic findings were described. The endothelial cells contained an abundance of cytoplasmic filaments, but they contained a small number of Weibel‐Palade bodies. Two types of endothelial cells, light and dark, were found in our specimen. The former had a cytoplasm with an abundance of ribosomes, rough endoplasmic reticulum and scant filaments. The latter had a cytoplasm with numerous cytoplasmic filaments and a well‐developed Golgi apparatus. Tight junctions were seen between the endothelial cells. The majority of the pericytes were accompanied with the vessels in the tumor. Three types of pericytes were recognized: endothelial cell‐like, fibroblast‐like, and smooth muscle cell‐like pericytes.

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Ultrastructural Study of Hemangiomas

Cited by 4 publications

References 16 publications

A hepatic sclerosed hemangioma with significant morphological change over a period of 10 years: a case report

A hepatic sclerosed hemangioma with significant morphological change over a period of 10 years: a case report

Hepatic hemangiomas

Ultrastructural Study of Hemangiomas

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