Ultrastructural study of focal epithelial hyperplasia

Buchner, Amos; Bubis, José; Ramon, Ytzchak

doi:10.1016/0030-4220(75)90204-2

Cited by 17 publications

(4 citation statements)

References 7 publications

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“…A review of the hterature reveals that epithelial hyperplasia characterized by mild hyperparakeratosis, acanthosis and elongation of rete ridges are consistent histomorphologic findings in FEH (1,2,5,7,8,(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36). Viral cytopathogenic effects including koilocytic cells, mitosoid cells and swollen cells showing a ballooning type of nuclear degeneration have been described in FEH.…”

Section: Discussionmentioning

confidence: 80%

Detection of human papillomavirus (HPV) DNA in focal epithelial hyperplasia

Garlick

Calderon

Buchner

et al. 1989

J Oral Pathology Medicine

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Five focal epithelial hyperplasia (FEH) specimens from four patients were examined by Southern blot hybridization analysis to determine the specific human papillomavirus (HPV) types present. The histomorphologic features of these specimens were also evaluated and a broad variety of changes including koilocytes, mitosoid cells, ballooning cells and cells showing individual cell keratinization were noted. FEH lesions from the three patients sharing a familial relationship demonstrated HPV DNA sequences that were either the prototype HPV-13 or a very closely related HPV-13 subtype. These patients also showed similar clinical features. Lesional tissue from the other patient was found to harbor HPV DNA sequences similar to HPV-32. In view of these findings it is suggested that these specific HPV types are associated with the characteristic FEH histomorphology described.

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Section: Discussionmentioning

confidence: 80%

Detection of human papillomavirus (HPV) DNA in focal epithelial hyperplasia

Garlick

Calderon

Buchner

et al. 1989

J Oral Pathology Medicine

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“…In our elcctronmicroscopic studies we observed in the upper stratum spinosum clear cells with degenerative changes, similar to those described by Clausen & Willis (1971) and Hanks et al (1972) containing virus-like particles; we were however unable to find these particles in our material. Ultrastructural studies by Orfanos et al (1974) and Buchner, Bubis & Ramon (1975) also did not confirm these previous findings of virus-like particles in epithelial cells. In our studies a conspicuous finding in the clear cells in the upper stratum spinosum was the presence of large intracytoplasmic vacuoles.…”

Section: Discussionmentioning

confidence: 72%

“…The condition is benign and may be chronic. Spontaneous disappearance was reported by Archard et a/., (1965), Buchner & Mass (1973b), Decker & de Guzman (1969) and Schock (1969). Treatment is unnecessary and often unsuccessful.…”

Section: Discussionmentioning

confidence: 75%

Focal epithelial hyperplasia of the oral mucosa.

Starink

Woerdeman

1977

Br J Dermatol

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“…The disease is featured by single or multiple fibrous, well-defined lesions like nodules and papules which frequently coalesce, with a size range from 0.1 cm to 1 cm in diameter. These lesions are usually painless and mainly found on the mucosa epithelia of the lower lip, upper lip, tongue and hard palate (Buchner et al, 1975;Mealey et al, 1993;Morrow et al, 1993;Pilgard, 1984;Sawyer et al, 1983). The main histological characteristics include epidermal acanthosis and parakeratosis, thickening and elongation of the rete ridges, and pronounced koilocytosis with characteristic mitosoid figures (van Wyk et al, 1977a).…”

Section: Introductionmentioning

confidence: 94%