Ultrastructural studies of cilia formation during thyroid gland differentiation in grass snake embryos

Trace Amine-Associated Receptor 1 Localization at the Apical Plasma Membrane Domain of Fisher Rat Thyroid Epithelial Cells Is Confined to Cilia

“…Accordingly, it is assumed that only few ligand and receptor molecules are sufficient to mediate ligand-triggered signaling via G-proteins either at the plasma membrane or by intracellular signaling microdomains [42]. Hence, it was proposed that GPCR signaling depends on their assembly in specific subdomains of the plasma membrane, such as lipid raft-like microdomains or in cilia [43,44,45]. Indeed, the findings of our present study support the interpretation that the Taar1 protein is targeted to and follows the secretory pathway to reach cilia at the apical plasma membrane domain of thyroid epithelial cells in situ and in vitro.…”

“…In clear contrast, it is important to note that Taar1 is present in the primary cilium of thyroid epithelial cells, as detected in this study. Primary cilia are formed by many cell types; typically only one copy is present per cell, which is also the case for thyrocytes [31,44,49,50]. To our knowledge, no reports have been presented on GPCRs localized to the apical plasma membrane domain of thyroid epithelial cells.…”

Histologic and ultrastructural observations on the thyroid gland of the White Fulani (Zebu) cattle in Northern Nigeria

“…However, the study of Martin et al (1988) on primary cilia in the follicular epithelium of the human thyroids showed that the structure and immotility of these cilia makes it unlikely to be related to motility function as in other cells. Cilia have also been suggested as vital cellular component for chemosensation (detection of a specific ligand, growth factor, hormone or morphogen) (Rupik, 2013). It physiological roles in chemical sensation in many endocrinal glands has also been suggested (Emmer et al, 2010).…”

Hollowing or cavitation during follicular lumen formation in the differentiating thyroid of grass snake Natrix natrix L. (Lepidosauria, Serpentes) embryos? An ultrastructural study

“…3D). In the ultrathin sections at this developmental stage, numerous transverse sections of cilia were also visible (see Rupik, 2012 for a complete description). The mass of dying cells was bordered by a discontinuous plasma membrane (Fig.…”