Ultrastructural features of the choline acetyltransferase-containing neurons and relationships with nigral dopaminergic and cortical afferent pathways in the rat striatum

Dimova, R; Vuillet, J.; Nieoullon, A.; Goff, Lydia Kerkerian‐Le

doi:10.1016/0306-4522(93)90489-3

Cited by 88 publications

(52 citation statements)

References 37 publications

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“…In 27% of recordings, inhibiting GABA A receptors revealed an EPSC mediated by activation of ionotropic glutamate receptors (Fig. 5B), which might originate from glutamate corelease by dopaminergic axons (Stuber et al, 2010;Tecuapetla et al, 2010;Tritsch et al, 2012). Because of its small conductance relative to that of IPSCs (EPSC: 0.6 Ϯ 0.1 pS, n ϭ 16; IPSC: 7.0 Ϯ 0.9 pS, n ϭ 37, p Ͻ 0.01), the net initial effect of synaptic stimulation of SNc axons on membrane potential is a small IPSP (Fig.…”

Section: First Componentmentioning

confidence: 98%

“…CINs receive synaptic inputs from midbrain dopamine neurons (Pickel and Chan, 1990;Dimova et al, 1993) and express both G␣ s -coupled dopamine D 5 receptors (of the D 1 receptor family) and G␣ i -coupled dopamine D 2 receptors (Yan et al, 1997;Yan and Surmeier, 1997). Indeed, pharmacological activation of D 1 and D 2 receptor families in vivo respectively increases and decreases ACh levels in striatum (Stoof et al, 1992;DeBoer and Abercrombie, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…The net effect of synaptically released dopamine on CIN excitability is unclear. Moreover, midbrain dopamine neurons release several neurotransmitters (Stuber et al, 2010;Tecuapetla et al, 2010;Tritsch et al, 2012), and their effects might not be limited to the actions of dopamine.…”

Section: Introductionmentioning

confidence: 99%

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Multiphasic Modulation of Cholinergic Interneurons by Nigrostriatal Afferents

Straub

Tritsch

Hagan

et al. 2014

Journal of Neuroscience

105

107

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The motor and learning functions of the striatum are critically dependent on synaptic transmission from midbrain dopamine neurons and striatal cholinergic interneurons (CINs). Both neural populations alter their discharge in vivo in response to salient sensory stimuli, albeit in opposite directions. Whereas midbrain dopamine neurons respond to salient stimuli with a brief burst of activity, CINs exhibit a distinct pause in firing that is often followed by a period of increased excitability. Although this "pause-rebound" sensory response requires dopaminergic signaling, the precise mechanisms underlying the modulation of CIN firing by dopaminergic afferents remain unclear. Here, we show that phasic activation of nigrostriatal afferents in a mouse striatal slice preparation is sufficient to evoke a pause-rebound response in CINs. Using a combination of optogenetic, electrophysiological, and pharmacological approaches, we demonstrate that synaptically released dopamine inhibits CINs through type 2 dopamine receptors, while another unidentified transmitter mediates the delayed excitation. These findings imply that, in addition to their direct effects on striatal projection neurons, midbrain dopamine neurons indirectly modulate striatal output by dynamically controlling cholinergic tone. In addition, our data suggest that phasic dopaminergic activity may directly participate in the characteristic pause-rebound sensory response that CINs exhibit in vivo in response to salient and conditioned stimuli.

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Section: First Componentmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multiphasic Modulation of Cholinergic Interneurons by Nigrostriatal Afferents

Straub

Tritsch

Hagan

et al. 2014

Journal of Neuroscience

105

107

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“…to this point, C U T + terminals in striatum have been shown to lie in close proximity to tyrosine hydroxylasepositive terminals (Pickel and Chan, 1990;Dimova et al, 19931, allowing for the possibility that FGF could be released by cholinergic processes and then acquired and retrogradely transported by dopaminergic afferents. The dopaminergic neurons of the substantia nigra are known to produce and respond to BDNF, neurotrophin-3, and FGF (Knusel et al, 1990;Bean et al, 1991;Spina et al, 1992;Hyman et al, 1994;Seroogy et al, 1994), suggesting that these factors have a normal autocrine role in dopaminergic neuronal survival.…”

Section: Discussionmentioning

confidence: 97%

Acidic fibroblast growth factor mRNA is expressed by basal forebrain and striatal cholinergic neurons

et al. 1996

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Evidence for the importance of the basal forebrain cholinergic system in the maintenance of cognitive function has stimulated efforts to identify trophic mechanisms that protect this cell population from atrophy and dysfunction associated with aging and disease. Acidic fibroblast growth factor (aFGF) has been reported to support cholinergic neuronal survival and has been localized in basal forebrain with the use of immunohistochemical techniques. Although these data indicate that aFGF is present in regions containing cholinergic cell bodies, the actual site of synthesis of this factor has yet to be determined. In the present study, in situ hybridization techniques were used to evaluate the distribution and possible colocalization of mRNAs for aFGF and the cholinergic neuron marker choline acetyltransferase (ChAT) in basal forebrain and striatum. In single-labeling preparations, aFGF mRNA-containing neurons were found to be codistributed with ChAT mRNA+ cells throughout all fields of basal forebrain, including the medial septum/diagonal band complex and striatum. By using a double-labeling (colormetric and isotopic) technique, high levels of colocalization (over 85%) of aFGF and ChAT mRNAs were observed in the medial septum, the diagonal bands of Broca, the magnocellular preoptic area, and the nucleus basalis of Meynert. The degree of colocalization was lower in the striatum, with 64% of the cholinergic cells in the caudate and 33% in the ventral striatum and olfactory tubercle labeled by the aFGF cRNA. These data demonstrate substantial regionally specific patterns of colocalization and support the hypothesis that, via an autocrine mechanism, aFGF provides local trophic support for cholinergic neurons in the basal forebrain and the striatum.

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“…Projections coming from the cerebral cortex, the pars compacta of the substantia nigra and the thalamus are known to synapse both on projection neurons and interneurons (Kubota et al, 1987;Vuillet et al, 1990;Dimova et al, 1993;Bennett and Bolam, 1994;Kachidian et al, 1996Kachidian et al, , 1998Smith, 1996, 1999;Koó s and Tepper, 1999;Rudkin and Sadikot, 1999). Striatal inputs may influence the striatal output through directing their contacts onto striatal projection neurons or by exciting the interneurons which synchronize the discharge of several striatal projection neurons (Koó s and Tepper, 1999).…”

Section: Introductionmentioning

confidence: 99%

A sequential protocol combining dual neuroanatomical tract-tracing with the visualization of local circuit neurons within the striatum

Gonzalo

Moreno

Erdozain

et al. 2001

Journal of Neuroscience Methods

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We describe here an experimental approach designed to aid in the identification of complex brain circuits within the rat corpus striatum. Our aim was to characterize in a single section (i) striatal thalamic afferents, (ii) striatopallidal projection neurons and (iii) striatal local circuit interneurons. To this end, we have combined anterograde tracing using biotinylated dextran amine and retrograde neuroanatomical tracing with Fluoro-Gold. This dual tracing protocol was further implemented with the visualization of different subpopulations of striatal interneurons. The subsequent use of three different peroxidase substrates enabled us to unequivocally detect structures that were labeled within a three-color paradigm.

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Ultrastructural features of the choline acetyltransferase-containing neurons and relationships with nigral dopaminergic and cortical afferent pathways in the rat striatum

Cited by 88 publications

References 37 publications

Multiphasic Modulation of Cholinergic Interneurons by Nigrostriatal Afferents

Multiphasic Modulation of Cholinergic Interneurons by Nigrostriatal Afferents

Acidic fibroblast growth factor mRNA is expressed by basal forebrain and striatal cholinergic neurons

A sequential protocol combining dual neuroanatomical tract-tracing with the visualization of local circuit neurons within the striatum

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