Ultrastructural Cytochemical and Ultrastructural Morphological Differences Between Human Multinucleated Giant Cells Elicited by Wear Particles from Hip Prostheses and Artificial Ligaments at the Knee

Anazawa, Ukei; Hanaoka, Hironari; Morioka, Hideo; Morii, Takeshi; Toyama, Yoshiaki

doi:10.1080/019131290882411

Cited by 14 publications

(4 citation statements)

References 30 publications

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“…These effects are reported to be associated with surgical trauma during insertion of implants [41]. Multinucleated giant cells can be elicited by wear particles in periprosthetic tissues in human specimens and these cells might contain phagocytized wear particles [42]. These findings cited above are in accordance with the histological observations made in undecalcified, resin embedded human bone and implant sections in the present study.…”

Section: Histological Analysessupporting

confidence: 91%

Analysis of titanium and other metals in human jawbones with dental implants – A case series study

Reichl

Wang

et al. 2016

Dental Materials

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Section: Histological Analysessupporting

confidence: 91%

Analysis of titanium and other metals in human jawbones with dental implants – A case series study

Reichl

Wang

et al. 2016

Dental Materials

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“…These histological changes were compatible with the advanced inflammation observed, including bone marrow injury during implant insertion 184 . Furthermore, the presence of MNGC in the peri‐implant tissues was likely triggered by the release of Ti particles from implants to engulf debris, similar to the TRAP+ MNGCs described in the orthopedic field 184,185 …”

Section: Implant‐related Factors Altering Bone Metabolismsupporting

confidence: 62%

Emerging factors affecting peri‐implant bone metabolism

Insua,

Galindo‐Moreno,

Miron

et al. 2023

Periodontology 2000

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Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting bone metabolism. Among these patients, smokers are known to have impaired bone metabolism and thus be subject to higher risks of early implant failure and/or late complications related to the stability of the peri‐implant bone and mucosal tissues. Notably, however, emerging data have unveiled other critical factors affecting osseointegration, namely, those related to the metabolism of bone tissues. The aim of this review is to shed light on the effects of implant‐related factors, like implant surface or titanium particle release; surgical‐related factors, like osseodensification or implanted biomaterials; various drugs, like selective serotonin reuptake inhibitors, proton pump inhibitors, anti‐hypertensives, nonsteroidal anti‐inflammatory medication, and statins, and host‐related factors, like smoking, diet, and metabolic syndrome on bone metabolism, and aseptic peri‐implant bone loss. Despite the infectious nature of peri‐implant biological complications, these factors must be surveyed for the effective prevention and management of peri‐implantitis.

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“…Both of these cells are located in close proximity during peri‐implantitis [Konttinen et al, 2006]. FBGCs observed near rejected implants are reported to be TRAP‐positive [Anazawa et al, 2004]. Conversely, FBGCs that are generated during culture, in vitro, are TRAP‐negative [Moreno et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

Foreign body giant cells and osteoclasts are TRAP positive, have podosome‐belts and both require OC‐STAMP for cell fusion

Khan

Hashimi

Bakr

et al. 2013

J of Cellular Biochemistry

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Macrophages have the ability to fuse and form multinucleated giant cells such as Osteoclast (OCs) and FBGCs. Osteoclast stimulatory transmembrane protein (OC-STAMP) is an important cell surface protein involved in the formation of OCs. This study sought to determine if OC-STAMP also regulates formation of FBGCs using expression analysis and subsequent inhibition studies. qPCR and Western blot analysis showed that OC-STAMP expression is significantly higher in FBGCs compared to control monocytes (P < 0.05). Four days following cell culture, OCs were positive for TRAP and F-actin ring formation, but FBGCs were not. In contrast, FBGCs were positive for TRAP and showed podosome belts comprised of F-actin on Day 8. FBGCs were subsequently plated onto dentine, but despite presenting some morphologic features of OCs (OC-STAMP expression, TRAP reactivity, and podosome belts) they failed to resorb bone. To evaluate a role for OC-STAMP in FBGCs, we inhibited this cell surface protein with anti-OC-STAMP antibody and observed that cell fusion and podosome belt formation was inhibited in both OCs and FBGCs. Our data support the hypothesis that OC-STAMP is a regulatory molecule for FBGCs; and that they are functionally distinct from OCs, despite similarities in gene expression profile, podosome belt formation, and TRAP expression.

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Ultrastructural Cytochemical and Ultrastructural Morphological Differences Between Human Multinucleated Giant Cells Elicited by Wear Particles from Hip Prostheses and Artificial Ligaments at the Knee

Cited by 14 publications

References 30 publications

Analysis of titanium and other metals in human jawbones with dental implants – A case series study

Analysis of titanium and other metals in human jawbones with dental implants – A case series study

Emerging factors affecting peri‐implant bone metabolism

Foreign body giant cells and osteoclasts are TRAP positive, have podosome‐belts and both require OC‐STAMP for cell fusion

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