Ultrastructural changes induced by benzo[a]pyrene in sea bass (Dicentrarchus labrax) liver and intestine: Importance of the intoxication route

Effects of PCBs on Liver Ultrastructure and Monooxygenase Activities in Japanese Quail

“…The lower glycogen content observed in the livers of PCB-treated quail seems to tally with the decreased number of glycogen patches observed in benzo(a)pyreneand PCB-contaminated fish (Lemaire et al, 1992;Hugla et al, 1995).…”

“…Apart from this work, deformations of hepatocyte nuclei have been mentioned in only one other in vivo study, which focused on sea bass (Dicentrarchus labrax) contaminated with benzo(a)pyrene (Lemaire et al, 1992). PCBs have not been found to affect the shape of hepatocyte nuclei in mammals or White Peking ducks (Williams et al, 1993).…”

Juvenile Sea Bass Liver P450, EROD Induction, and Erythrocytic Genotoxic Responses to PAH and PAH-like Compounds

“…Nuclear morphological alterations in sea bass liver and intestine cells were observed as a characteristic consequence of B(a)P either oral or injection treatment (Lemaire et al, 1992), indicating the high reactivity of B(a)P metabolites which form covalent adducts with DNA in "sh (Varanasi et al, 1986;Hofe and Pu!er, 1986;Lemaire et al, 1990, Peters et al, 1997. According to Lemaire and co-workers (1990), the presence of B(a)P metabolites in other organs is due to their general blood circulation.…”

“…Some of those studies, which include mature (Novi et al, 1998) and immature (Lemaire et al, 1996;Viarengo et al, 1997;Jacksic et al, 1998) sea bass treated with di!erent BNF or 3-methylcholanthrene (3-MC) intraperitoneal injections, indicated EROD activity induction. Other sea bass studies revealed di!erences in liver and intestine B(a)P ultrastructural e!ects, as well as metabolic kinetics and metabolite distribution in relation to the route of exposure (Lemaire et al, 1990(Lemaire et al, , 1992. Morphological nuclear enterocyte and hepatocyte modi"cations were also found as a characteristic consequence of sea bass B(a)P oral contamination (Lemaire et al, 1992).…”

“…Other sea bass studies revealed di!erences in liver and intestine B(a)P ultrastructural e!ects, as well as metabolic kinetics and metabolite distribution in relation to the route of exposure (Lemaire et al, 1990(Lemaire et al, , 1992. Morphological nuclear enterocyte and hepatocyte modi"cations were also found as a characteristic consequence of sea bass B(a)P oral contamination (Lemaire et al, 1992). The incidence of morphological nuclear modi"-cations, such as EMN and ENA, induced by PAHs have not been thoroughly investigated.…”