Ultrastructural Changes in the Adenohypophysis of Metyrapone-Treated Rabbits

Cameron, E. C.; Foster, C. L.

doi:10.1677/joe.0.0520343

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…Ultrastructural characteristics of the ACTH cells i.e. peripheral arrangement of small sized secretory granules along the plasmalemma correspond to those reported in rat (Nakayama et al, 1969;Siperstein & Miller, 1970); rabbit (Cameron & Foster, 1972); cow (Mikami, 1970) and mink (Murphy & James, 1976) supporting the present observations. The Malayan flying bat, Pteropus vampyrus, Reeder et al (2006) reported that the bats restraint stress for 15-60 minutes results in a significant increase in plasma levels of ACTH and glucocorticoid.…”

Section: Corticotroph (Acth Cells)supporting

confidence: 92%

Ultrastructural Characterization of the Pars Distalis of the Indian Female Sheath-Tailed Bat, Taphozous longimanus (Hardwicke)

Nerkar

Gadegone

2010

Int. J. Morphol.

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SUMMARY:The present ultrastructural observations demonstrate the presence of six cell types in the pars distalis of nonpregnant and pregnant bats of Taphozous longimanus. In the pars distalis of T. longimanus, STH cells are round to oval with eccentrically placed nucleus, numerous secretory granules and well developed Golgi indicate a cell under vigorous synthetic activity while those filled with secretory granules with reduced Golgi complex suggest reserve or storage state of cells. LTH cell is characterized by the large secretory granules, dilated endoplasmic reticulum and numerous mitochondria in the cytoplasm which indicate that these cells are hypertrophied and synthetically very active during pregnancy. ACTH cells are found either singly or in groups and are elongated or angular with long cytoplasmic processes. The size and peripheral arrangement of secretory granules are characteristic of ACTH cell. TSH cells are distributed mostly towards the periphery of the pars distalis of T. longimanus. They are elongated, polygonal or triangular in shape. The secretory granules are small, electron dense, 150-200 nm in diameter. The rough endoplasmic reticulum is very well developed. In FSH, the secretory granules are small (200 to 400 nm) and less in number and are distributed towards the periphery of the cell. FSH cells show well developed mitochondria, Golgi and rough endoplasmic reticulum indicating active state of FSH during estrus and pregnancy. The hypertrophy of FSH and LH cells during pregnancy is associated with filigreed cytoplasmic pattern giving a bizarre appearance. At late pregnancy, FSH and LH cells are highly active and synthesize large quantities of hormone as indicated by the development of cell organelles.

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Section: Corticotroph (Acth Cells)supporting

confidence: 92%

Ultrastructural Characterization of the Pars Distalis of the Indian Female Sheath-Tailed Bat, Taphozous longimanus (Hardwicke)

Nerkar

Gadegone

2010

Int. J. Morphol.

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“…Ultrastructural cha racteristics of the ACTH granules include their small size (< 150 nm), and peripheral arrangement ( fig.21). This description of the presumptive ACTH cell of the mink conforms with that of the rat [N akayama el a!., 1969], rabbit [C ameron and Foster, 1972] and cow [M ik am i. 1970], Rosette formations of what may be glycogen are more common in mink ACTH cells than in other mink adenohypophyseal cells.…”

Section: The Ampliophil or Acth Cellsupporting

confidence: 71%

Cells of the adenohypophysis of the mink (<i>Mustela vison</i>) identified by immunohistochemical and functional criteria

Murphy¹,

James²

1976

Cells Tissues Organs

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Six cell types were described in the adenohypophysis of the mink, and a putative function was assigned to each type. These cells are the two types of gonadotrophic cells, a thyrotrophic hormone (TSH) cell, a somatotrophic (STH) cell, a prolactin (PRL) cell and a corticotrophin-producing (ACTH) cell. Gonadotrophic cells were identified by an immunolocalization technique using antisera to ovine LH. TSH cells and ACTH cells were identified by ablation of respective target organs and observation of the subsequent hypertrophic cells in the pituitary, as well as comparison with published descriptions in other species. STH cells were identified by comparison with published reports. PRL cells were observed in lactating animals and animals in lactational withdrawal.

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“…Adrenocorticotrophin-secreting cells (ACTH cells) have not been firmly identified in the pars distalis of the rabbit. Cells that are likely to be unusually stimulated adrenocorticotrophs have been described (Cameron & Foster, 1972).…”

Section: Introductionmentioning

confidence: 99%

Histological and Ultrastructural Changes in the Pars Distalis of the Rabbit Pituitary in Organ Culture

Pathak¹,

Fisk²

1974

Journal of Endocrinology

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Typical histological and ultrastructural changes that occur in the pars distalis of the rabbit pituitary after different periods of organ culture are described. The best technique for the maintenance of the maximum proportion of the explant was assessed by comparing cultures grown under different conditions. Explants in air with a medium buffered with N-2\x=req-\ hydroxyethylpiperazine-N1-2-ethanesulphonic acid (HEPES), not previously used in organ culture, proved more satisfactory than explants in carbogen with bicarbonate-buffered 199, and cultures were maintained for more than 3 weeks.The survival of cells was assessed on the basis of their cytological integrity; DNA-and RNA-fluorescence with acridine orange was a valuable indicator.Prolactin cells, which were few in uncultured controls, became the most common type of granular cell in long-term cultures.Cell modifications during culture included the development of a peripheral epithelioid layer and the appearance of numerous microvilli. Microfibrils, coated or smooth vesicles, lytic bodies, desmosomes and intranuclear rods became more common and intranuclear rodlets (fibrous or membranous structures) were identified. Cells often became more electron dense during long-term culture.Though there was an increase in the number of agranular cells during culture, identifiable granules were retained by many cells throughout culture.

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Ultrastructural Changes in the Adenohypophysis of Metyrapone-Treated Rabbits

Cited by 9 publications

References 14 publications

Ultrastructural Characterization of the Pars Distalis of the Indian Female Sheath-Tailed Bat, Taphozous longimanus (Hardwicke)

Ultrastructural Characterization of the Pars Distalis of the Indian Female Sheath-Tailed Bat, Taphozous longimanus (Hardwicke)

Cells of the adenohypophysis of the mink (<i>Mustela vison</i>) identified by immunohistochemical and functional criteria

Histological and Ultrastructural Changes in the Pars Distalis of the Rabbit Pituitary in Organ Culture

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