Cells of the adenohypophysis of the mink (&lt;i&gt;Mustela vison&lt;/i&gt;) identified by immunohistochemical and functional criteria

Murphy, Bruce D.; James, Day

doi:10.1159/000144554

Cited by 15 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrastructural characteristics of the ACTH cells i.e. peripheral arrangement of small sized secretory granules along the plasmalemma correspond to those reported in rat (Nakayama et al, 1969;Siperstein & Miller, 1970); rabbit (Cameron & Foster, 1972); cow (Mikami, 1970) and mink (Murphy & James, 1976) supporting the present observations. The Malayan flying bat, Pteropus vampyrus, Reeder et al (2006) reported that the bats restraint stress for 15-60 minutes results in a significant increase in plasma levels of ACTH and glucocorticoid.…”

Section: Corticotroph (Acth Cells)supporting

confidence: 92%

Ultrastructural Characterization of the Pars Distalis of the Indian Female Sheath-Tailed Bat, Taphozous longimanus (Hardwicke)

Nerkar

Gadegone

2010

Int. J. Morphol.

View full text Add to dashboard Cite

SUMMARY:The present ultrastructural observations demonstrate the presence of six cell types in the pars distalis of nonpregnant and pregnant bats of Taphozous longimanus. In the pars distalis of T. longimanus, STH cells are round to oval with eccentrically placed nucleus, numerous secretory granules and well developed Golgi indicate a cell under vigorous synthetic activity while those filled with secretory granules with reduced Golgi complex suggest reserve or storage state of cells. LTH cell is characterized by the large secretory granules, dilated endoplasmic reticulum and numerous mitochondria in the cytoplasm which indicate that these cells are hypertrophied and synthetically very active during pregnancy. ACTH cells are found either singly or in groups and are elongated or angular with long cytoplasmic processes. The size and peripheral arrangement of secretory granules are characteristic of ACTH cell. TSH cells are distributed mostly towards the periphery of the pars distalis of T. longimanus. They are elongated, polygonal or triangular in shape. The secretory granules are small, electron dense, 150-200 nm in diameter. The rough endoplasmic reticulum is very well developed. In FSH, the secretory granules are small (200 to 400 nm) and less in number and are distributed towards the periphery of the cell. FSH cells show well developed mitochondria, Golgi and rough endoplasmic reticulum indicating active state of FSH during estrus and pregnancy. The hypertrophy of FSH and LH cells during pregnancy is associated with filigreed cytoplasmic pattern giving a bizarre appearance. At late pregnancy, FSH and LH cells are highly active and synthesize large quantities of hormone as indicated by the development of cell organelles.

show abstract

Section: Corticotroph (Acth Cells)supporting

confidence: 92%

Ultrastructural Characterization of the Pars Distalis of the Indian Female Sheath-Tailed Bat, Taphozous longimanus (Hardwicke)

Nerkar

Gadegone

2010

Int. J. Morphol.

View full text Add to dashboard Cite

show abstract

“…1972] and the thyrotrophs of the female rabbit [Salazar. 1963] and female mink [Murphy and James. 1976], The most convincing evidence for the presence of the TSH cell type in the anterior pituitary is afforded by the results of surgical and chemical thyroidec tomy.…”

Section: Tsh Cell Typementioning

confidence: 99%

“…1963], bovine pituitary [Mikami. 1970] and mink [Murphy and James. 1976], The above findings provide a direct evidence for the existence of TSH cells in the bat pituitary.…”

Section: Tsh Cell Typementioning

confidence: 99%

See 1 more Smart Citation

Ultrastructural and Functional Characteristics of Anterior Pituitary Cells in the Indian Fruit Bat, <i>Rousettus leschenaulti</i> (Desmarest)

Bhiwgade¹,

Akolkar²,

Menon³

et al. 1989

Cells Tissues Organs

View full text Add to dashboard Cite

The pituitary glands of normal and experimental male and female bats were examined by light and electron microscopy. Six cell types were identified in the anterior pituitary by differential staining techniques, ultrastructural characteristics and changes brought about during the different phases of the sexual cycle. Conventional methods like removal of thyroids, testes and adrenals, and animals in lactation withdrawal and treatment with propylthio-uracil, cyproterone acetate and metyrapone were employed. A marked predominance of somatotrophin and luteotrophin (LTH) cells were present in the intact adult female bat pituitary gland. LTH cells were also observed in milk retention experiments. The two gonadotrophic cell types were randomly distributed throughout the gland. Hypertrophy of two gonadotroph cells was observed in response to the physiological conditions of the animals, gonadectomy and administration of the male antifertility drug cyproterone acetate.Thyrotrophin and adrenocorticotrophin cells were identified by ablation of the respective target organs, thyroids and adrenals, and after treatment with propylthio-uracil and metyrapone. On the basis of the pathological conditions of the bats, the possible functional significance of the different cell types is also discussed.

show abstract

“…3), presumably due to the removal of an ovarian substance which normally acts on the hypothalamus, resulting in suppression of LH secretion. Ovariectomy in mink will result in hypertrophy of gonadotrophic cells of the anterior pituitary (Murphy & James, 1976), suggesting that the ovary has a negative feedback effect in this species. In the present study, the duration of the elevation of LH was brief and differed little whether animals were ovariectomized before or after embryo implantation (Text-figs 3 & 4), although it was more variable after implantation.…”

Section: Discussionmentioning

confidence: 99%

Effects of medroxyprogesterone acetate on gestation in mink

Murphy¹,

Concannon²,

Travis³

1982

Reproduction

View full text Add to dashboard Cite

Mink ovariectomized 14 days after the first of two matings received injections of 2 mg MPA, the same MPA treatment + an oestradiol-17 beta implant or no replacement therapy. Some mink were ovariectomized after implantation and given a single dose of 2 mg MPA or no replacement therapy. MPA persisted in the serum at detectable levels for 13 or more days in all mink treated. MPA and MPA + oestradiol induced uterine growth but neither treatment was capable of inducing embryo implantation. More embryos were retained in mink treated with MPA alone and these appeared to be viable. Implanted embryos persisted for a longer period in animals that were ovariectomized and treated with MPA. MPA neither supported pregnancy nor permitted parturition. Serum LH was elevated by 1 week after ovariectomy and elevations persisted for a further 20 or more days. While MPA alone had no apparent negative feedback effects on LH, animals that received MPA + oestradiol did not display any elevation of LH, suggesting that oestradiol or a combination of MPA and oestradiol has a potent negative feedback in mink.

show abstract

Cells of the adenohypophysis of the mink (<i>Mustela vison</i>) identified by immunohistochemical and functional criteria

Cited by 15 publications

References 14 publications

Ultrastructural Characterization of the Pars Distalis of the Indian Female Sheath-Tailed Bat, Taphozous longimanus (Hardwicke)

Ultrastructural Characterization of the Pars Distalis of the Indian Female Sheath-Tailed Bat, Taphozous longimanus (Hardwicke)

Ultrastructural and Functional Characteristics of Anterior Pituitary Cells in the Indian Fruit Bat, <i>Rousettus leschenaulti</i> (Desmarest)

Effects of medroxyprogesterone acetate on gestation in mink

Contact Info

Product

Resources

About