Effects of medroxyprogesterone acetate on gestation in mink

Murphy, B. D.; Concannon, P W; Travis, H. F.

doi:10.1530/jrf.0.0660491

Cited by 17 publications

(6 citation statements)

References 13 publications

(20 reference statements)

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“…Murphy et al (1982,1983) showed the importance of ovarian factors in implantation by demonstrating that ovariectomy during embryonic quiescence consistently prevents implantation. Exogenous progesterone or medroxyprogesterone acetate failed to correct the situation and pregnancies could not be shortened by this treatment (Hansson, 1947;Hammon, 1951b;Holcomb, 1967;Murphy et al, 1982Murphy et al, , 1983Murphy, 1983a;Christiansen, 1985). Contrary to these findings, some investigators (Concannon et al, 1980;Jarosz & Dukelow, 1985) found evidence that medroxyprogesterone could advance the time of implantation.…”

Section: Oogénesis and Ovulationmentioning

confidence: 96%

Reproduction and fertility in the mink (Mustela vison)

Sundqvist¹,

Amador²,

Bartke³

1989

Reproduction

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Section: Oogénesis and Ovulationmentioning

confidence: 96%

Reproduction and fertility in the mink (Mustela vison)

Sundqvist¹,

Amador²,

Bartke³

1989

Reproduction

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“…Further, a single estrogen injection terminates diapause in rodents (Dey et al 2004). Treatment of carnivores in obligate (Murphy et al 1982) or marsupials in seasonal (Fletcher et al 1988) delay with estrogen does not induce reactivation of the embryo. Nonetheless, estrogens have pleiotropic mitogenic and mitotic effects on target tissues, mediated through classic nuclear receptors, membrane estrogen receptors and actions of multiple intracellular effectors (Frasor et al 2003) and may, in the appropriate concentration and temporal sequence, reactivate embryos in diapause.…”

Section: Regulation Of the Cell Cycle In Diapause And Reactivationmentioning

confidence: 99%

Embryonic diapause and its regulation

Lopes¹,

Desmarais²,

Murphy³

2004

Reproduction

183

165

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Embryonic diapause, a condition of temporary suspension of development of the mammalian embryo, occurs due to suppression of cell proliferation at the blastocyst stage. It is an evolutionary strategy to ensure the survival of neonates. Obligate diapause occurs in every gestation of some species, while facultative diapause ensues in others, associated with metabolic stress, usually lactation. The onset, maintenance and escape from diapause are regulated by cascades of environmental, hypophyseal, ovarian and uterine mechanisms that vary among species and between the obligate and facultative condition. In the bestknown models, the rodents, the uterine environment maintains the embryo in diapause, while estrogens, in combination with growth factors, reinitiate development. Mitotic arrest in the mammalian embryo occurs at the G0 or G1 phase of the cell cycle, and may be due to expression of a specific cell cycle inhibitor. Regulation of proliferation in non-mammalian models of diapause provide clues to orthologous genes whose expression may regulate the reprise of proliferation in the mammalian context.

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“…Removal of the ovaries and replacement with P4 during early pregnancy in the ferret maintained viable blastocysts in the uterus. An injection of estradiol, as in the mouse and rat on the same hormone regimen, did not cause implantation (65)(66)(67)). An unidentified 60-kDa protein had been shown to be necessary for embryo implantation in ferrets (68).…”

Section: Ferret-signal For Implantationmentioning

confidence: 88%

My Scientific Journey: From an Agrarian Start to an Academic Setting

Bahr

2017

Annu. Rev. Anim. Biosci.

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This article is a combination of an autobiography and a review of outstanding research done by over 70 graduate students, postdoctoral fellows, and visiting scientists along with excellent collaborators during my over-40-year career as a professor of reproductive physiology at the University of Illinois, UrbanaChampaign. I have also shared thoughts on mentoring, how research has changed over the years, and the future of reproductive physiology. I provide the reader with a snapshot of the challenges faced by a woman eager to obtain a PhD under the guidance of renowned professors in the early 1970s and to be hired as the first woman, and the only permanent female faculty member, for more than 20 years on a faculty of 40 men. As a comparative reproductive physiologist, I describe the various animal models used because they were the best models to answer specific questions in reproduction. Also, my graduate students and postdoctoral fellows were given the freedom to identify their research topics, articulate hypotheses to be tested, and select appropriate animal models. This approach caused students to take ownership of their research, resulting in the development of independent and creative scientists and over 170 publications, excluding chapters in top-tier journals. Finally, I am so grateful for a truly rich life mentoring graduate students and postdoctoral fellows who have become my lifelong friends.

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Effects of medroxyprogesterone acetate on gestation in mink

Cited by 17 publications

References 13 publications

Reproduction and fertility in the mink (Mustela vison)

Reproduction and fertility in the mink (Mustela vison)

Embryonic diapause and its regulation

My Scientific Journey: From an Agrarian Start to an Academic Setting

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