Ultrastructural Changes in Nuclei Within HIV-1-Induced Cultured Cell Syncytia

Harris, J. R. W.

doi:10.1007/978-1-4613-0667-2_99

Cited by 1 publication

(2 citation statements)

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“…This is a rather difficult observation to reconcile with viral budding and also with the known mRNP nuclear-cytoplasmic translocation process that is believed to occur at the nuclear pore complexes. Our own data (Harris, 1990;Harris et al, 1990) have shown that in the single cells and MNGCs actively producing large quantities of virus, a morphological change is detectable at the nuclear envelope. The nuclear pore complexes increase in prominance, this being expressed by a thickening, i.e.…”

Section: G Nuclear Changes Within Multinucleate Giant Cellsmentioning

confidence: 84%

“…The somewhat limited data presented above serves to indicate that the HIV-1 infected C8166 lymphoblastid suspension culture system expresses a complex dynamic situation within which cellular events relating to: (1) viral integration, replication and release, (2) cell fusion, (3) MNGC formation and (4) MNGC ageing and death can be investigated at the ultrastructural level. The survey presented represents only a small fraction of the available data, some of which has already been published elsewhere (Harris et al, 1989: Harris, 1990).…”

Section: H Degeneration Of Multinucleate Giant Cells In Cuhurementioning

confidence: 99%

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The ultrastructure of multinucleate giant cells

Harris

1993

Micron

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A survey of the available ultrastructural data on physiologically and pathologically occurring and virally-induced multinucleate giant cells (MNGCs) is presented. Emphasis is initially placed upon the bone osteoclast, the skeletal muscle myotube and the placental syncytiotrophoblast. The widespread occurrence of MNGCs in a range of pathological situations is discussed, with emphasis upon the broad involvement of the macrophage in inflammatory responses. Many viruses produce cell fusion in vivo and in vitro when cell cultures are infected. Several examples are given. A clear distinction is drawn between viral fusion from "without" and viral fusion from "within" the cell. The cytopathic effect (CPE) of the animal and human retroviruses is discussed in considerable detail. The in vivo and in vitro formation of lymphocytic and macrophage MNGCs by HIV-1 is given extensive coverage. The possible significance of the presence of brain MNGCs of macrophage/ microglial origin as a cellular feature of AIDS dementia is discussed. A new hypothesis is advanced relating to the possible role of endogenous C-type retrovirus in the physiological fusion of the invasive placental cytotrophoblasts to create the syncytiotrophoblast. The evolutionary and developmental significance of such an event in relation to the evolution of the placental mammals is discussed. The possible importance of MNGC formation in the depletion of the CD4 ÷ population of T-lymphocytes in vivo in the clinical progression of the AIDS-related complex and AIDS is related to the potent fusogenic effect of HIV-I when cell cultures are infected.

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Section: G Nuclear Changes Within Multinucleate Giant Cellsmentioning

confidence: 84%

Section: H Degeneration Of Multinucleate Giant Cells In Cuhurementioning

confidence: 99%