Ultrastructural aspects of lymphoreticular cells in rheumatoid synovium.

Neumark, T; Farkas, K

doi:10.1136/ard.32.6.524

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…However, very recently Quimby et al (1978) have reported that there is no homology using techniques of competitive hybridisation between the cDNA of this virus and RNA from cells of dogs and human beings with SLE. Measles was chosen because of its association with subacute sclerosing panencephalitis in man, a slow chronic progressive condition (Hall and ter Meulen, 1976), and also structures like paramyxovirus nucleocapsids have been described in synovial lymphoreticular cells in rheumatoid arthritis (Neumark and Farkas, 1973). Finally rubella was selected for the reasons outlined in McCormick et al (1978).…”

Section: Discussionmentioning

confidence: 99%

Search for viral nucleic sequences in rheumatoid cells.

Norval¹,

Smith²

1979

Annals of the Rheumatic Diseases

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SUMMARY DNA and RNA were extracted from synovial membranes, synovial fibroblast cells, peripheral blood lymphocytes, and synovial fibroblast cells strains derived from patients with rheumatoid arthritis and other joint conditions. They were hybridised after immobilisation on nitrocellulose filters with iodinated viral nucleic acids extracted from measles, rubella virus, SV-40, and a retrovirus, RD-1 14. In addition, in-situ hybridisation was carried out on sections of synovial membranes by means of iodinated measles and rubella virus RNA. In no case did any hybridisation occur. Positive control systems included synovial fibroblast strains transformed with

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Section: Discussionmentioning

confidence: 99%

Search for viral nucleic sequences in rheumatoid cells.

Norval¹,

Smith²

1979

Annals of the Rheumatic Diseases

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Ultrastructure of the Stroma of Nasal Polyps: Cilia in Stromal Fibroblasts

Busuttil¹,

More²,

McSeveney³

1976

Archives of Otolaryngology - Head and Neck Surgery

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Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membrane

Ishikawa

Ziff

1976

Arthritis & Rheumatism

138

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The perivascular infiltrates of the rheumatoid synovium were examined in the electron microscope. Lymphocyte-rich, plasma cell-rich, and transitional areas were observed. The transitional areas contained lymphocytes, plasma cells, blast cells, macrophages, and fibroblasts. Although lymphoblasts were frequent, the blast cells were predominantly plasmablasts. Marked degeneration of fibroblasts in the vicinity of lymphoblasts suggested the liberation of a lymphotoxin by the lymphoblasts. There was close contact between blast cells and macrophages and between macrophages and lymphocytes. The close association of lymphoblasts, plasmablasts, and macrophages in the transitional areas suggests that these are sites of T-and B-cell interaction in the rheumatoid synovial immune response.Previous electron microscopic studies (1-5) have shown that large numbers of lymDhocytes and plasma

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Ultrastructural aspects of lymphoreticular cells in rheumatoid synovium.

Cited by 8 publications

References 12 publications

Search for viral nucleic sequences in rheumatoid cells.

Search for viral nucleic sequences in rheumatoid cells.

Ultrastructure of the Stroma of Nasal Polyps: Cilia in Stromal Fibroblasts

Electron microscopic observations of immunoreactive cells in the rheumatoid synovial membrane

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