Ultrastructural, Antigenic and Physicochemical Characterization of the Mojuí dos Campos (Bunyavirus) Isolated from Bat in the Brazilian Amazon Region

Wanzeller, Ana Lucia Monteiro; Diniz, José Antônio Picanço; Gomes, Maria L C; Cruz, Ana Cecília Ribeiro; Soares, M. C. P.; Souza, Wanderley de; Rosa, A.P.A. Travassos da; Vasconcelos, Pedro F. C.

doi:10.1590/s0074-02762002000300005

Cited by 7 publications

(4 citation statements)

References 22 publications

(21 reference statements)

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“…Bangui virus (BGIV) is an unclassified bunyavirus and was isolated from an unidentified bat in the Central African Republic (CAR) [31]. Mojuí dos Campos virus (MDCV) is another ungrouped bunyavirus isolated from an unidentified bat species [32,33].…”

Section: Members Of the Order Bunyaviralesmentioning

confidence: 99%

Can Bats Serve as Reservoirs for Arboviruses?

Fagre

Kading

2019

Viruses

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Bats are known to harbor and transmit many emerging and re-emerging viruses, many of which are extremely pathogenic in humans but do not cause overt pathology in their bat reservoir hosts: henipaviruses (Nipah and Hendra), filoviruses (Ebola and Marburg), and coronaviruses (SARS-CoV and MERS-CoV). Direct transmission cycles are often implicated in these outbreaks, with virus shed in bat feces, urine, and saliva. An additional mode of virus transmission between bats and humans requiring further exploration is the spread of disease via arthropod vectors. Despite the shared ecological niches that bats fill with many hematophagous arthropods (e.g. mosquitoes, ticks, biting midges, etc.) known to play a role in the transmission of medically important arboviruses, knowledge surrounding the potential for bats to act as reservoirs for arboviruses is limited. To this end, a comprehensive literature review was undertaken examining the current understanding and potential for bats to act as reservoirs for viruses transmitted by blood-feeding arthropods. Serosurveillance and viral isolation from either free-ranging or captive bats are described in relation to four arboviral groups (Bunyavirales, Flaviviridae, Reoviridae, Togaviridae). Further, ecological associations between bats and hematophagous viral vectors are characterized (e.g. bat bloodmeals in mosquitoes, ingestion of mosquitoes by bats, etc). Lastly, knowledge gaps related to hematophagous ectoparasites (bat bugs and bed bugs (Cimicidae) and bat flies (Nycteribiidae and Streblidae)), in addition to future directions for characterization of bat-vector-virus relationships are described.

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Section: Members Of the Order Bunyaviralesmentioning

confidence: 99%

Can Bats Serve as Reservoirs for Arboviruses?

Fagre

Kading

2019

Viruses

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“…While some of these viruses, like Bhanja virus, Batai/Chittoor virus, Nairobi sheep disease virus (NSDV)/Ganjam virus, Sathuperi virus, sandfly fever Naples and Sicilian viruses, Palma virus, Ingwavuma virus, and Thottapalayam virus, have shown serosignatures in humans and animals (22)(23)(24)(25), the role of many of these viruses in causing human diseases remains incompletely understood. Importantly, human infections with Ganjam virus have been reported in laboratory workers involved in the isolation of this virus (26).…”

mentioning

confidence: 99%

Malsoor Virus, a Novel Bat Phlebovirus, Is Closely Related to Severe Fever with Thrombocytopenia Syndrome Virus and Heartland Virus

Mourya

Yadav

Basu

et al. 2014

J Virol

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During a survey in the year 2010, a novel phlebovirus was isolated from the Rousettus leschenaultii species of bats in western India. The virus was identified by electron microscopy from infected Vero E6 cells. Phylogenic analysis of the complete genome showed its close relation to severe fever with thrombocytopenia syndrome (SFTS) and Heartland viruses, which makes it imperative to further study its natural ecology and potential as a novel emerging zoonotic virus.

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“…The Golgi body is located close to one side of the nucleus (frequently within an indentation), and the tubular viral factories are connected to both rough endoplasmic reticulum and numerous mitochondrial profiles, as in Bunyamwera virus morphogenesis [ 24 ]. The Golgi body becomes increasingly disrupted, and enveloped particles can be seen within Golgi-derived vesicles being trafficked towards the cell membrane for exocytosis, as described for other orthobunyaviruses [ 16, 25 ].…”

Section: Resultsmentioning

confidence: 99%

Isolation of a novel orthobunyavirus from bat flies (Eucampsipoda africana)

Vuren

Wiley

Palacios

et al. 2017

Journal of General Virology

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The Bunyaviridae family comprises viruses causing diseases of public and veterinary health importance, including viral haemorrhagic and arboviral fevers. We report the isolation, identification and genome characterization of a novel orthobunyavirus, named Wolkberg virus (WBV), from wingless bat fly ectoparasites (Eucampsipoda africana) of Egyptian fruit bats (Rousettus aegyptiacus) in South Africa. Complete genome sequence data of WBV suggests it is most closely related to two bat viruses (Mojuí dos Campos and Kaeng Khoi viruses) and an arbovirus (Nyando virus) previously shown to infect humans. WBV replicates to high titres in VeroE6 and C6-36 cells, characteristic of mosquito-borne arboviruses. These findings expand our knowledge of the diversity of orthobunyaviruses and their insect vector host range.

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Ultrastructural, Antigenic and Physicochemical Characterization of the Mojuí dos Campos (Bunyavirus) Isolated from Bat in the Brazilian Amazon Region

Abstract: The Mojuí dos Campos virus (MDCV) was isolated from the blood of an unidentified bat (Chiroptera) captured in Mojuí dos Campos, Santarém, State of Pará, Brazil, in 1975 and considerated

Cited by 7 publications

References 22 publications

Can Bats Serve as Reservoirs for Arboviruses?

Can Bats Serve as Reservoirs for Arboviruses?

Malsoor Virus, a Novel Bat Phlebovirus, Is Closely Related to Severe Fever with Thrombocytopenia Syndrome Virus and Heartland Virus

Isolation of a novel orthobunyavirus from bat flies (Eucampsipoda africana)

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