Purpose
To analyze and compare the reactions at the interface between the composite,
composed of fragmented heterologous mineralized bone matrix (MOMHF) and
polymethylmethacrylate (PMMA), and the rabbit’s tibias, through macroscopic
evaluation and scanning electron microscopy (SEM) in different periods.
Methods
In this study, 12 New Zealand adult rabbits were used (E1: n = 3, E2: n = 3,
E3: n = 3 and E4: n = 3). They had the right tibial defects filled with
composite and were evaluated immediately after surgery and at 30, 60, 90,
and 120 days.
Results
The composites were incorporated and integrated into the recipient beds in
100% of the cases, defined by the MOMHF osseointegration and the PMMA
fibrointegration, with no sign of infection, migration, or rejection.
Conclusions
The behavior of the composites in the recipient beds demonstrates that these
biomaterials have the potential to be used in bone defect repairs, offering,
thus, better quality of life to the orthopedic patient.