Ultrastructural Abnormalities in the Skin Nerves of a Patient with Scleredema adultorum (Buschke) and Diabetes mellitus

Staak, W.J.B.M. van de; Bergers, A.M.G.

doi:10.1159/000251339

Cited by 7 publications

(1 citation statement)

References 4 publications

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“…Myelin sheaths may be destroyed or split (9,(11)(12)(13). In the cutaneous nerves, the most distal portions of the peripheral nerves, electron microscopy has revealed the same degenerative changes in the axons and the Schwann cells as those seen in large peripheral nerve stems (3,4,15). In fact, several similar types ( Figs.…”

Section: Discussionmentioning

confidence: 75%

Cutaneous Nerves in Patients with Diabetic Neuropathy

Mihara

Takeda

Shimao

1987

The Journal of Dermatology

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Since the role of cutaneous nerves in the pathogenesis of cutaneous diseases associated with diabetes mellitus is not well defined, cutaneous nerves in ten patients with severe diabetic neuropathy were electron microscopically investigated as a preliminary study. The specimens were taken from normal-appearing skin of their lower extremities, Cutaneous nerves were seen as axon-Schwann cell complexes in which variously degenerated axons and Schwann cells coexisted with normal ones. The degenerative changes were not, however, specific for diabetes mellitus.

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Section: Discussionmentioning

confidence: 75%

Cutaneous Nerves in Patients with Diabetic Neuropathy

Mihara

Takeda

Shimao

1987

The Journal of Dermatology

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Connective Tissue Disorders in Diabetes

Rosenbloom¹

2004

International Textbook of Diabetes Mellitus

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Connective tissue disorders in diabetes encompass the major long‐term complications, which can be attributed to alternation in the quantity and quality of structural macromolecules of the extracellular matrix. This chapter reviews the abnormalities of interstitial connective tissue involving skeleton, joints, skin, and periarticular tissues that have been considered to be associated with diabetes, including osteopenia in children and adults; hyperostosis; osteoarthritis; rheumatoid arthritis; osteolysis; scleroderma diabeticorum; Dupuytren disease; stiff hand syndrome of Lundbaek; carpal tunnel syndrome; flexor tenosynovitis; adhesive capsulitis of the shoulder and shoulder–hand syndrome; and limited joint mobility (LJM). Despite an extensive literature defining the characteristic features of the six distinct conditions resulting in limitation of hand joint mobility, recognition of the fact that these are different entities, although they may coexist, is often not appreciated. Among these conditions affecting hand joint mobility, LJM is unique in that it can occur in children and adolescents, in whom it was originally described, does not occur in the nondiabetic young population, is an important risk marker for other complications, correlates with long‐term metabolic control, and has markedly decreased in frequency over the past 20 years, presumably as a result of improved control of type 1 diabetes in children.

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Connective tissue disorders in diabetes

Rosenbloom

2015

International Textbook of Diabetes Mellitus

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Ultrastructural Abnormalities in the Skin Nerves of a Patient with Scleredema adultorum (Buschke) and Diabetes mellitus

Abstract: In an electron-microscopic study of the skin of a patient with scleredema adultorum (Buschke) and diabetes mellitus, the unmyelinated nerve fibres showed accumulations of glycogen. On morphological grounds, these accumulations appeared to be located in the axons.

Cited by 7 publications

References 4 publications

Cutaneous Nerves in Patients with Diabetic Neuropathy

Cutaneous Nerves in Patients with Diabetic Neuropathy

Connective Tissue Disorders in Diabetes

Connective tissue disorders in diabetes

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