Cutaneous Nerves in Patients with Diabetic Neuropathy

Mihara, Motoyuki; Takeda, Atsushi; Shimao, Shuhei

doi:10.1111/j.1346-8138.1987.tb03626.x

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…This study demonstrates that the dermal nerve fibre profile area in the lower leg skin of diabetics with established autonomic and sensorimotor peripheral neuropathy is uni-formly redueed. Previous studies have shown ultrastruetural nerve changes (not specific for diabetes) that have included perineural basement membrane thickening and axonal degeneration [2,3]. Faerman et al [7], using a silver-staining technique on diabetic skin biopsies, showed an association between changes in the nerve fibres around sweat glands and a diminished sweat test.…”

Section: Discussionmentioning

confidence: 99%

“…eleetron microscopy has shown a reduction in their number in diabetic neuropathy [1]. Axonal vaeuolation and multiplieation of the Sehwann cell basement membrane are found [2,3]-Immunohistochemieal studies show a reduction in the general neuronal marker protein gene produet 9.5 [4], a decrease in vasoactive intestinal polypeptide (VIP) reactivity at sweat glands [5] and a reduction in substance P (SP)-and calcitonin gene-related peptide (CGRP)-reaetive nerve fibres in the dermis [6]. Neuropeptide changes are associated with some manifestations of diabetie autonomic neuropathy, for example, sweating abnormalities.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous nerves in diabetic neuropathy: an immunohistochemical study

Al-Abadie

Gawkrodger

Senior

et al. 1993

Acad Dermatol Venereol

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Background Diabetic neuropathy is usually investigated using the invasive sural nerve biopsy technique; while little is known about dermal nerve alteration in diabetic neuropathy. Patients and Methods Skin biopsies from the lower leg of five diabeties (mean age, 55 years) with autonomic and sensorimotor peripheral neuropathy were compared to biopsies from five non-diabetic controls (mean age, 47 years). Immunohistochemical methods were employed using the anti-neurofilament monoclonal antibodies 127.11 and UJ 13A. The dermal nerve profile areas were counted with a Quantimet image analyser. Results The diabetie biopsies gave significantly lower readings than the controls (/'<0.05, Mann-Whitney L'-test). Conclusion Skin biopsy is a simple and reliable method for evaluating distal nerves in diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cutaneous nerves in diabetic neuropathy: an immunohistochemical study

Al-Abadie

Gawkrodger

Senior

et al. 1993

Acad Dermatol Venereol

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Hypoglycaemic neuropathy: occurrence of axon terminals in plantar skin and plantar muscle of diabetic BB/Wor rats treated with insulin implants

Mohseni¹,

Lillesaar²,

Theodorsson

et al. 2000

Acta Neuropathol

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It is generally believed that diabetic neuropathy is due to chronic hyperglycaemia. However, experience from insulinoma patients and experimental studies show that hypoglycaemia may also cause neuropathy. Accordingly, the plantar nerves of diabetic eu-/hypoglycaemic BB/Wor rats treated with insulin implants exhibit a distinct neuropathy. To what extent hypoglycaemic neuropathy affects axon terminals in skin and muscle is unknown. In the present study we examine the occurrence of epidermal axon profiles and the neuropeptide calcitonin gene-related peptide (CGRP) in plantar skin, and of end plate axon terminals in a plantar muscle of diabetic BB/Wor rats subjected to long periods of hypoglycaemia. The number of protein gene product-immunoreactive axon profiles was found to be normal in heel skin biopsy specimens from eu-/hypoglycaemic rats, but many profiles were short and thin. The content of CGRP in the skin biopsy samples was significantly below normal. After staining with antibodies against the vesicular acetylcholine transporter protein, the occurrence of end plate axon terminals was significantly reduced in sections from the flexor hallucis brevis muscle of eu-/hypoglycaemic rats. Moreover, the end plate axon terminals tended to be abnormally small in these rats. We conclude that the hypoglycaemic neuropathy seen in plantar nerve trunks of diabetic BB/Wor rats treated with insulin implants is accompanied by mild alterations in the epidermal innervation of plantar skin and a more obviously abnormal nerve terminal pattern in plantar muscle.

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Structure and function of the free nerve ending of the skin nerve.

Ishihara¹

1999

Nishinihon J Dermatol

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Cutaneous Nerves in Patients with Diabetic Neuropathy

Cited by 3 publications

References 14 publications

Cutaneous nerves in diabetic neuropathy: an immunohistochemical study

Cutaneous nerves in diabetic neuropathy: an immunohistochemical study

Hypoglycaemic neuropathy: occurrence of axon terminals in plantar skin and plantar muscle of diabetic BB/Wor rats treated with insulin implants

Structure and function of the free nerve ending of the skin nerve.

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