Ultrastretchable and Wireless Bioelectronics Based on All‐Hydrogel Microfluidics

Liu, Yaming; Yang, Tiyun; Zhang, Yuyan; Qu, Gang; Wei, Shanshan; Liu, Zhou; Kong, Tiantian

doi:10.1002/adma.201902783

Cited by 127 publications

(109 citation statements)

References 44 publications

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“…If wearable microfluidic devices are made of materials with high conformability without wrinkling, folding or moving on the skin, they can sense the smallest movements and vibrations. Recently, hydrogels have been used for microfluidic applications since they exhibit a high degree of stretchability [192,193]. Hydrogels can conform to the skin very well.…”

Section: Future Perspectivesmentioning

confidence: 99%

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

et al. 2019

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Miniaturization has been the driving force of scientific and technological advances over recent decades. Recently, flexibility has gained significant interest, particularly in miniaturization approaches for biomedical devices, wearable sensing technologies, and drug delivery. Flexible microfluidics is an emerging area that impacts upon a range of research areas including chemistry, electronics, biology, and medicine. Various materials with flexibility and stretchability have been used in flexible microfluidics. Flexible microchannels allow for strong fluid-structure interactions. Thus, they behave in a different way from rigid microchannels with fluid passing through them. This unique behaviour introduces new characteristics that can be deployed in microfluidic applications and functions such as valving, pumping, mixing, and separation. To date, a specialised review of flexible microfluidics that considers both the fundamentals and applications is missing in the literature. This review aims to provide a comprehensive summary including: (i) Materials used for fabrication of flexible microfluidics, (ii) basics and roles of flexibility on microfluidic functions, (iii) applications of flexible microfluidics in wearable electronics and biology, and (iv) future perspectives of flexible microfluidics. The review provides researchers and engineers with an extensive and updated understanding of the principles and applications of flexible microfluidics.

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Section: Future Perspectivesmentioning

confidence: 99%

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

et al. 2019

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“…Hydrogels are promising candidate materials for implantable and wearable bioelectronics owing to their water-containing chemical structures resembling soft tissues and their tunable mechanical properties such as flexibility and stretchability [ [1] , [2] , [3] , [4] ]. The currently available hydrogel bioelectronics lack multifunctional characteristics to fully adapt to biological environments.…”

Section: Introductionmentioning

confidence: 99%

Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics

Jia

Hou

et al. 2021

Bioactive Materials

143

103

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Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA. The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid. The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone, providing the hydrogels with long-term and repeatable adhesiveness, similar to the adhesion of mussels. The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network, thereby improving its mechanical properties and conductivity. Furthermore, the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag. Owing to these advantages, the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive, antibacterial, and implantable bioelectrode to detect bio-signals, and as a wound dressing to accelerate tissue regeneration while preventing infection. Therefore, this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis.

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“…[ 15,16 ] Devices may be completely autonomous with embedded energy sources or energy harvesting mechanisms [ 17–19 ] as well as printed or embedded wireless communication platforms. [ 20–22 ] Additive processes become progressively more relevant when miniaturization of devices takes place and where electronic functionality has to be adapted to meet customers’ requirements frequently. By hybridization of independent processes, a fabrication of a functional device is enabled.…”

Section: Introductionmentioning

confidence: 99%

Hybrid structural electronics printing by novel dry film stereolithography and laser induced forward transfer

Levy

Toker²,

Winter³

et al. 2021

Nano Select

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3D printing has seen much progress in recent decades with the introduction of new materials and printing techniques. This article describes the combination of a novel, stereolithography (SLA) based method for structural material buildup with laser induced forward transfer (LIFT) printing of conductive and resistive elements and placement of commercial active and passive components for the additive manufacturing of 3D functional electronic devices. The structural material is composed of dry film photoresists that are exposed and laminated to form a stack which is later developed to remove unexposed area and reveal the desired free form shape. Interconnection using pillar penetration between the structural layers is described in detail. Several examples of functional objects (lamp, microphone) demonstrate the practicality of this novel, multi material printing method.

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Ultrastretchable and Wireless Bioelectronics Based on All‐Hydrogel Microfluidics

Cited by 127 publications

References 44 publications

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

Flexible Microfluidics: Fundamentals, Recent Developments, and Applications

Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics

Hybrid structural electronics printing by novel dry film stereolithography and laser induced forward transfer

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