Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics

Abstract

Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA. The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid. The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone, providing the hydrogels with long-term and repeatable adhesiveness, similar to the adhesion of mussels. The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network, thereby improving its mechanical properties and conductivity. Furthermore, the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag. Owing to these advantages, the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive, antibacterial, and implantable bioelectrode to detect bio-signals, and as a wound dressing to accelerate tissue regeneration while preventing infection. Therefore, this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis.

Application of Nanomaterial in Hydrogels Related to Wound Healing

“…Improving mechanical properties In situ polymerization [59], electrospinning technology [60], casting and coordination interaction [61][62][63][64] Drug release Three-tier structure [65] and embedding [66] Cross-linked and direct interaction [26,49,58,[67][68][69][70] Antibacterial effect [39] Interfering with DNA replication and RNA production Destroy cell membranes Interference with cellular respiration Change enzyme conformation and inactivate enzyme activity Increased adhesion…”

“…At present, the design of nanoenzymes focuses on improving the catalytic activity of nanoenzymes. Although the activity of nanoenzymes has been greatly improved, it is a challenging task to use nanoenzymes to construct multifunctional biological materials so as to meet the needs of different environments [58].…”

Soft materials for wearable supercapacitors

“…Heretofore, the development of soft materials for supercapacitors that can be deformed into arbitrary shapes and adapt to random musculoskeletal deformations in the human body is still a considerable challenge. [231][232][233][234][235] which could be further applied as soft electrodes for WSCs. In these previous studies, polydopamine (PDA) was combined with the hydrogels, which endows the hydrogels with good shef-adhesivness that inspired by mussel [236].…”

Rational engineering and applications of functional bioadhesives in biomedical engineering

“…For sensor applications hesive for biosignal recording. [153] The bioadhesive was fabricated by dispersing TA-chelated Ag (TA-Ag) nanozyme into a PAA hydrogel. The Ag nanoparticles provide both antibacterial property and conductivity.…”