Rational engineering and applications of functional bioadhesives in biomedical engineering

Park, Jae; Kim, Yeon-Ju; Chun, Beomsoo; Seo, Jungmok

doi:10.1002/biot.202100231

Cited by 11 publications

(5 citation statements)

References 164 publications

(250 reference statements)

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“…NHS ester modification to the hydrogel enables it to form covalent bonding with tissue surfaces containing primary amine groups. [ 3 ] Critically, the toughness of the hydrogel allows it to endure strong covalent adhesion, thereby preventing cohesive failure. Figure S11 (Supporting Information) shows a photograph of the NHS‐functionalized hydrogel adhered to porcine skin.…”

Section: Resultsmentioning

confidence: 99%

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A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

Park,

Kim,

Kim

et al. 2023

Advanced Science

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Hydrogels are used in wound dressings because of their tissue‐like softness and biocompatibility. However, the clinical translation of hydrogels remains challenging because of their long‐term stability, water swellability, and poor tissue adhesiveness. Here, tannic acid (TA) is introduced into a double network (DN) hydrogel consisting of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) to realize a tough, self‐healable, nonswellable, conformally tissue‐adhesive, hemostatic, and antibacterial hydrogel. The TA within the DN hydrogel forms a dynamic network, enabling rapid self‐healing (within 5 min) and offering effective energy dissipation for toughness and viscoelasticity. Furthermore, the hydrophobic moieties of TA provide a water‐shielding effect, rendering the hydrogel nonswellable. A simple chemical modification to the hydrogel further strengthens its interfacial adhesion with tissues (shear strength of ≈31 kPa). Interestingly, the TA also can serve as an effective hemostatic (blood‐clotting index of 58.40 ± 1.5) and antibacterial component, which are required for a successful wound dressing. The antibacterial effects of the hydrogel are tested against Escherichia coli and Staphylococcus aureus. Finally, the hydrogel is prepared in patch form and applied to a mouse model to test in vivo biocompatibility and hemostatic performances.

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Section: Resultsmentioning

confidence: 99%

“…Currently, bioadhesive glues, including fibrin glue and cyanoacrylate, are primarily used clinically. [ 3 ] Their liquid‐like properties allow them to seamlessly penetrate the irregular rough geometries of tissue surfaces. Then, the penetrated glues are cured to ensure cohesion.…”

Section: Introductionmentioning

confidence: 99%

A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

Park,

Kim,

Kim

et al. 2023

Advanced Science

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“…Moreover, conformally attaching devices made of dry and rigid materials to soft and moist tissue surfaces is highly challenging. In this regard, various studies have reported adhesive materials to implement stable device-tissue interfaces . In this section, we provide the most recent and widely reported adhesive materials for bioelectronics classified as (1) mussel-inspired, (2) bioinspired architectures, and (3) slug-inspired.…”

Section: Interfacial Compatibilitymentioning

confidence: 99%

Functional Bioelectronic Materials for Long-Term Biocompatibility and Functionality

Park

Lee

Kim

et al. 2022

ACS Appl. Electron. Mater.

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Wearable and implantable bioelectronics have received a great deal of interest since the need for personalized healthcare systems has arisen. Bioelectronics are designed to detect biological signals and apply medical treatments, thereby enabling patients to monitor and manage their health conditions. However, current bioelectronics lack long-term stability, biocompatibility, and functionality after implantation into the human body. In particular, the intrinsically different natures of the devices and human tissue result in low device–tissue compatibility. The obstacles for this can be defined as (1) physical, (2) biological, and (3) interfacial. The mechanical mismatch between rigid device materials and soft tissue results in physical incompatibility, which causes user discomfort and scar tissue formation. In addition, devices can show poor biocompatibility since the device materials are recognized as foreign bodies by the immune system. Accordingly, the applied devices can be toxic and/or induce an undesirable immune response and inflammation. Last, tissue environments are moist, irregular, and dynamic, which causes poor interfacial compatibility between the device and the human body. Herein, we describe various recent strategies to overcome limitations in the physical, biological, and interfacial compatibility of bioelectronics for long-term functionality in vivo. Moreover, in the last part of the review, we mention current limitations and future perspectives of bioelectronics for commercialization.

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“…A very sticky but viscous material will plastically deform before it debonds from a substrate, while a tougher material will manage to overcome adhesive forces during peeling. 18,19 1…”

Section: Adhesion and Interface Mechanicsmentioning

confidence: 99%

Materials and Devices for Stretchable Electronic Nerve Interfaces

Lienemann

2022

Linköping Studies in Science and Technology. Dissertations

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This thesis would not have been possible without the many people who supported me throughout my PhD. Here I wish to express my gratitude:My upmost gratitude goes of course to Klas. When I met you in Zürich I was told you are a brilliant and critical scientist. Now I know you are also a wonderful supervisor. Thanks for caring about me as a person as well as about my PhD. I have extreme respect for you as a supervisor and scientist. I cannot put into big enough words how thankful I am for the tremendous amount of support and knowledge I got from you! I will miss our midnight emails about science. It was an honor to be your first PhD student.Magnus, and the rest of LOE management I would like to thank for making LOE a huge group that still acts like a small one.Besides Klas, I also had several additional (unofficial) mentors that contributed greatly to the success of my PhD.Nadia, my mentor in life. Thanks for ever pushing me to achieve my potential. My motivation for this thesis stemmed to a great deal from wanting to make you and Klas proud. Thanks for believing in me. And thanks for always being there for me. Even commenting on many drafts of this thesis.Marie, my mentor at LOE. Thanks for teaching me the first things I needed to know as a new PhD student, always challenging me to work harder while at the same time luring me with frisbee and beers. Also, thanks for commenting on this thesis and for providing the first instance of the beautiful nerve figure that I have been using ever since in various new versions (also all over in this thesis).Mary, my mentor in the Lab. Thanks for your positive attitude and endless energy to get things done. It was wonderful to work with you on the PigSel project and your comments on this thesis were well appreciated.Aline, my long-distance mentor in Zürich. Thanks for 3 years of bi-weekly support-group meetings of 'people suffering from Klas' gold nanowire fabrication'. You explained and solved a great deal of my problems before they ever could become any up here in the north.To Simon and Johan, my surgeon mentors at Linköping university hospital, my sincerest thanks for happily implanting all the in vivo devices of this thesis over the last 3 years and teaching me firsthand biology.x Riki and Yianni, thanks for being there with me right from the start. You were the reason the SoftEs were not just about electronics, and that my PhD was not just about becoming a doctor, but also about The Doctor. Yianni especially, thanks for being my partner in crime inside and outside the lab. Thanks for caring for the happiness of people with your endless chaotic energy that powered friday beers, movie productions and gifts alike.A big thanks also to the other SoftEs. Thanks for making our group feel like a small family. Nara, thanks for your kind spirit and comments on this thesis. Mohsen, thanks for commenting on the mechanical part of this thesis and taking over all the lab duties from me. Aiman, thanks for being the good soul of the Rubberlab by always being there to talk about science an...

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Rational engineering and applications of functional bioadhesives in biomedical engineering

Cited by 11 publications

References 164 publications

A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

A Mechanically Resilient and Tissue‐Conformable Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care

Functional Bioelectronic Materials for Long-Term Biocompatibility and Functionality

Materials and Devices for Stretchable Electronic Nerve Interfaces

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