Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni

Domingues, Ana Lúcia Coutinho; Medeiros, Tibério Batista de; Lopes, Edmundo Pessoa

doi:10.1590/s0074-02762011000700004

Cited by 16 publications

(25 citation statements)

References 47 publications

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“…On top (Domingues et al 2011) exhibited that only the serum HA level versus other biological markers was capable of demarcating patients with mild from those with intense periportal fibrosis in human S.mansoni. Our present study demonstrated that serum HA level was significantly increased in S.mansoni patients when compared to control group individuals, which is consistent with reports suggested that HA a useful marker for evaluating schistosomiasis morbidity and yet capable of monitoring hepatic fibrosis reversal following appropriate therapy (Eboumbou et al 2005;Domingues et al 2011). Additionally; our results exposed direct significant correlation between plasma MDA and Schistosoma-provoked periportal fibrosis, proposing that plasma MDA could be a favorable indicative marker for hepatic fibrosis in Schistosoma patients, plus implying an important role of lipid peroxidation byproducts in Schistosoma induced pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection

Aziz

Yacoub

Rashid

et al. 2015

Acta Parasitologica

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Schistosomiasis is a debilitating parasitic disease, affects large number of host species. Currently affects 250-300 million people in tropic areas. Schistosoma pathogenic impact is hepatic periportal fibrosis; the parasite-induced inflammatory cellular activation promotes oxidative stress, resulting in lipid peroxidation (LPO), with subsequent increase in inflammatory mediators as malondialdehyde (MDA). This study was set up to reveal possible contribution of lipid peroxidation byproducts MDA in hepatic pathophysiology. Results displayed that MDA don't tend to change in relation with either age, nor hepatic transaminases AST & ALT, while exhibited a significant increase in MDA levels in human schistosomiasis versus control group P<0.0001 (Mn. ± St.dev. 7.77 ± 3.59, 1.21 ± 0.28 nmol/ml) respectively. Moreover; MDA plasma levels in Schistosoma infected group correlated significantly with two hepatic fibrosis parameters; (a) ultrasonography graded periportal fibrosis P< 0.0001. Levels of MDA in hepatic fibrosis grades 0, I, II, III in Schistosoma infected group were (Mn. ± St.dev. 2.8 ± 0.64, 4.3 ± 1.2, 9.3 ± 1.6 and 10.8 ± 1.3 nmol/ml) respectively, (b) serum Hyaluronic acid (HA) P<0.0001 (spearman r = 0.77) as a reliable hepatic fibrosis marker. This implies a considerable role of LPO byproducts in schistosomiasis pathogenicity, and proposing malondialdehyde as a biomarker for schistosomiasis morbidity.

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Section: Discussionmentioning

confidence: 99%

Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection

Aziz

Yacoub

Rashid

et al. 2015

Acta Parasitologica

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“…Serum levels of these biomarkers are significantly elevated with the progression of hepatic fibrosis and are hence important in qualitative and quantitative assessments of pathological status, including related complications, and also in monitoring the response to treatment. Procollagen III amino-terminal peptide, laminin, hyaluronic acid, chitinase 3-like protein 1, procollagen I carboxy-terminal peptide, procollagen IV C and N peptides, and metalloproteinase inhibitors are some examples of these biomarkers (294)(295)(296). In addition, different indices, based on routine investigative findings, are relevant in the assessment of hepatic disease.…”

Section: Diagnosis and Evaluation Of Schistosome-induced Liver Diseasementioning

confidence: 99%

“…In addition, different indices, based on routine investigative findings, are relevant in the assessment of hepatic disease. The aspartate amino transferase/platelet ratio index (APRI) is one such commonly considered indirect tool (296,297). Furthermore, a recent study suggested the possible application of the international normalized ratio (INR) and hyaluronic acid in estimating the degree of hepatic damage (298).…”

Section: Diagnosis and Evaluation Of Schistosome-induced Liver Diseasementioning

confidence: 99%

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Advances in the Diagnosis of Human Schistosomiasis

et al. 2015

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SUMMARY Schistosomiasis is a major neglected tropical disease that afflicts more than 240 million people, including many children and young adults, in the tropics and subtropics. The disease is characterized by chronic infections with significant residual morbidity and is of considerable public health importance, with substantial socioeconomic impacts on impoverished communities. Morbidity reduction and eventual elimination through integrated intervention measures are the focuses of current schistosomiasis control programs. Precise diagnosis of schistosome infections, in both mammalian and snail intermediate hosts, will play a pivotal role in achieving these goals. Nevertheless, despite extensive efforts over several decades, the search for sensitive and specific diagnostics for schistosomiasis is ongoing. Here we review the area, paying attention to earlier approaches but emphasizing recent developments in the search for new diagnostics for schistosomiasis with practical applications in the research laboratory, the clinic, and the field. Careful and rigorous validation of these assays and their cost-effectiveness will be needed, however, prior to their adoption in support of policy decisions for national public health programs aimed at the control and elimination of schistosomiasis.

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“…63,64 Many of these biomarkers have been evaluated and found useful in the diagnosis and grading of liver fibrosis caused by several conditions, including chronic viral hepatitis, alcoholic cirrhosis, non-alcoholic steatohepatitis, and schistosomiasis. 65 However, their ability to identify and grade liver fibrosis in schistosomiasis at the community level in endemic areas needs further evaluation. The performance of some direct serum markers in the evaluation of schistosome-induced hepatic fibrosis is discussed below and is summarized in Table 1.…”

Section: Serum Biological Markersmentioning

confidence: 99%

The chronic enteropathogenic disease schistosomiasis

Olveda¹,

Olveda

McManus

et al. 2014

International Journal of Infectious Diseases

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Schistosomiasis is a chronic enteropathogenic disease caused by blood flukes of the genus Schistosoma. The disease afflicts approximately 240 million individuals globally, causing approximately 70 million disability-adjusted life years lost. Chronic infections with morbidity and mortality occur as a result of granuloma formation in the intestine, liver, or in the case of Schistosoma haematobium, the bladder. Various methods are utilized to diagnose and evaluate liver fibrosis due to schistosomiasis. Liver biopsy is still considered the gold standard, but it is invasive. Diagnostic imaging has proven to be an invaluable method in assessing hepatic morbidity in the hospital setting, but has practical limitations in the field. The potential of non-invasive biological markers, serum antibodies, cytokines, and circulating host microRNAs to diagnose hepatic fibrosis is presently undergoing evaluation. This review provides an update on the recent advances made with respect to gastrointestinal disease associated with chronic schistosomiasis.

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Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni

Cited by 16 publications

References 47 publications

Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection

Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection

Advances in the Diagnosis of Human Schistosomiasis

The chronic enteropathogenic disease schistosomiasis

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