Ultrasound-Triggered Drug Release and Enhanced Anticancer Effect of Doxorubicin-Loaded Poly(D,L-Lactide-Co-Glycolide)-Methoxy-Poly(Ethylene Glycol) Nanodroplets

Du, Lina; Jin, Yiguang; Zhou, Wenying; Zhao, Jingyu

doi:10.1016/j.ultrasmedbio.2011.05.012

Cited by 49 publications

(28 citation statements)

References 30 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study, mPEG-poly(D,L-lactide-co-glycolide) (mPEG-PLGA) polymeric micellar system was loaded with Dox and perfluorocarbon. (164) The micelles were transformed into nanodroplets, which were transformed to nanobubbles at 37°C. The rate of tumor inhibition in the animal group treated with Dox-loaded nanodroplets combined with ultra-sound was 84.3 %, whereas the rate was 60.4 for animal group received the Dox-loaded nanodroplet-treatment without ultra-sound.…”

Section: Ultra-sound Sensitive Polymeric Micellesmentioning

confidence: 99%

Recent advances in polymeric micelles for anti-cancer drug delivery

Biswas

Kumari

Lakhani

et al. 2016

European Journal of Pharmaceutical Sciences

408

197

View full text Add to dashboard Cite

Section: Ultra-sound Sensitive Polymeric Micellesmentioning

confidence: 99%

Recent advances in polymeric micelles for anti-cancer drug delivery

Biswas

Kumari

Lakhani

et al. 2016

European Journal of Pharmaceutical Sciences

408

197

View full text Add to dashboard Cite

“…Controls were treated without insonation and named as CPP-CPT NB and CPT NB. The choice of acoustic parameters was based on the reference description with some modification (Du et al, 2011). At predetermined time intervals, 100 mL of samples was withdrawn, and the CPP-CPT concentration was determined as described above.…”

Section: Ultrasound Triggered Release Of Payloadmentioning

confidence: 99%

Ultrasound-responsive nanobubbles contained with peptide–camptothecin conjugates for targeted drug delivery

et al. 2015

View full text Add to dashboard Cite

To improve the targeting delivery efficiency of anticancer drug to tumor sites, a new strategy combining cell-permeable peptide (CPP) and ultrasound was reported in this article. In this study, we devised and tested a strategy for functional payload delivery to cells by loading CPP-camptothecin conjugate (CPP-CPT) into nanobubble (CPP-CPT NB). Here, CPP existing in the conjugation form of CPP and CPT was hidden in nanobubble to cloak the penetration activity of CPP. Meanwhile, local tumor ultrasound was utilized to achieve specific targeting of CPP-CPT to the tumor cells. The mean particle size of the prepared CPP-CPT NB was ∼200 nm, and the drug entrapment efficiency was >80%. Stimulated by ultrasound, over 90% of the entrapped CPP-CPTs would release from the nanobubbles. Subsequent research demonstrated that the CPP-CPT NB showed effective cellular uptake and significant cytotoxic activity in HeLa cells in vitro. Additionally, after systemic administration in mice, CPP-CPT NB with ultrasound showed a higher tumor inhibition effect in nude mice xenografted HeLa cells tumors and excellent body safety when compared with normal CPT injection group. In conclusion, the carrier constructed in this study would be a safe and efficiently drug delivery system for specific cancer treatment.

show abstract

“…To overcome this limitation, nanobubbles 11,20 and nanodroplets 13 with sizes smaller than 1 µm have been developed ( Figure 1B). Nanobubbles are generally prepared by sonicating in the presence of a fluorinated gas, such as perfluorocarbons or sulfur hexafluoride.…”

Section: Nanobubbles and Nanodropletsmentioning

confidence: 99%

“…[4][5][6][7] In recent times, drug-loaded ultrasound contrast agent systems, also termed ultrasound-responsive drug delivery systems (URDDS), have become an increasing focus of research. URDDS include microbubbles, [8][9][10] nanobubbles, 11,12 nanodroplets, 13 liposomes, 14,15 emulsion, 16 and micelles. [17][18][19] A combination of two or more formulations can be used as URDDS, such as liposomal bubbles 20,21 and microemulsions.…”

Section: Introductionmentioning

confidence: 99%

Potential and problems in ultrasound-responsive drug delivery systems

Zhao¹,

Du²,

Lu³

et al. 2013

IJN

View full text Add to dashboard Cite

Abstract:Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington's disease, thrombolysis, and disruption of the blood-brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.

show abstract

Ultrasound-Triggered Drug Release and Enhanced Anticancer Effect of Doxorubicin-Loaded Poly(D,L-Lactide-Co-Glycolide)-Methoxy-Poly(Ethylene Glycol) Nanodroplets

Cited by 49 publications

References 30 publications

Recent advances in polymeric micelles for anti-cancer drug delivery

Recent advances in polymeric micelles for anti-cancer drug delivery

Ultrasound-responsive nanobubbles contained with peptide–camptothecin conjugates for targeted drug delivery

Potential and problems in ultrasound-responsive drug delivery systems

Contact Info

Product

Resources

About