Recent advances in polymeric micelles for anti-cancer drug delivery

Biswas, Swati; Kumari, Preeti; Lakhani, Prit; Ghosh, Balaram

doi:10.1016/j.ejps.2015.12.031

Cited by 409 publications

(204 citation statements)

References 183 publications

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“…The hydrophobic core accommodates various hydrophobic molecules, such as therapeutics and imaging agents, thus improving the solubility and stability in the biological system. 20,21 The hydrophilic corona shields the core and protects the loaded drugs from interactions with the blood components. The biocompatible polymeric corona causes reduced recognition of the micelles by reticuloendothelial systems, thus providing prolonged circulation of the loaded component in the blood stream.…”

Section: Zhang Et Almentioning

confidence: 99%

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

Zhang¹,

Deyin²,

Che³

et al. 2017

IJN

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Section: Zhang Et Almentioning

confidence: 99%

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

Zhang¹,

Deyin²,

Che³

et al. 2017

IJN

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“…Such a small particle size could accumulate preferentially at the tumor by the EPR effect, which would enable a drug delivery system with a decreased drug concentration in healthy tissues and reduced side effects. 25,26 Aggregates were formed between pH 5.5 and pH 7 by the opposite-charge attraction of both blocks ( Figure 1D). …”

Section: Discussionmentioning

confidence: 99%

Intracellular “activated” two-photon photodynamic therapy by fluorescent conveyor and photosensitizer co-encapsulating pH-responsive micelles against breast cancer

Luo

Zhong

Liu

et al. 2017

IJN

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The application of photodynamic therapy (PDT) for the diagnosis and treatment of cancer is hindered by the intrinsic defects of the currently available photosensitizers (PSs), such as poor water solubility and limited light-penetration depth. In this study, pH-responsive polymeric micelles that co-encapsulate therapeutic PSs and organooxotin two-photon compounds were applied for two-photon PDT (TP-PDT) against breast cancer. The TP-PDT effect of the drug-loaded micelles was “activated” when the micelles turned into aggregates at a triggering pH level. The in vitro therapeutic effect was evaluated on 4T1 murine breast cancer cells by viability assays, real-time morphology collapsing, and reactive oxygen species determination. Time-dependent ex vivo organ distribution and in vivo anticancer efficacy results suggested that the drug carriers could accumulate in tumors and suppress tumor growth by TP-PDT. The delivery system could enhance the solubility and distribution of PSs and, if administered along with a tissue-penetrating prolonged light source, could thus have good potential for cancer therapy.

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“…Amphiphilic block copolymers (ABCs) spontaneously assemble into polymeric micelles that are nanoscopic with a core/shell architecture 37,38 . Poly(ethylene glycol)-block-poly(β-benzyl Laspartate) (PEG-PBLA) is an ABC that has been used as a starting point for polymeric micelles to deliver various chemotherapeutics 39,40 .…”

Section: Introductionmentioning

confidence: 99%

“…Polymeric micelles have the capacity to deliver multiple agents simultaneously and release of these molecules can be tailored through physical entrapment of chemical conjugation 37,38 . Amphiphilic block copolymers (ABCs) spontaneously assemble into polymeric micelles that are nanoscopic with a core/shell architecture 37,38 .…”

Section: Introductionmentioning

confidence: 99%

Combinatorial Polymeric Conjugated Micelles with Dual Cytotoxic and Antiangiogenic Effects for the Treatment of Ovarian Cancer

et al. 2016

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Emerging treatment paradigms like targeting the tumor microenvironment and/or dosing as part of a metronomic regimen are anticipated to produce better outcomes in ovarian cancer but current drug delivery systems are lacking. We have designed and evaluated paclitaxel (PTX) and rapamycin (RAP) micellar systems that can be tailored for various dosing regimens and target tumor microenvironment. Individual and mixed PTX:RAP (MIX-M) micelles are prepared by conjugating drugs to a poly(ethylene glycol)-block-poly(β-benzyl L-aspartate) using a pHsensitive linker. The micelles release the drug(s) at pH 5.5 indicating preferential release in the acidic endosomal/lysosomal environment. Micelles exhibit anti-proliferative effects in ovarian cell cancer lines (SKOV-3 and ES2) and an endothelial cell line (HUVEC) with the MIX-M being synergistic. The micelles also inhibited endothelial migration and tube formation. In healthy mice, micelles at 60 mg/kg/drug demonstrated no acute toxicity over 21 days. ES2 xenograft model efficacy studies at 20 mg/kg/drug dosed every 4 days and evaluated at 21 days indicate that the individual micelles exhibit anti-angiogenic effects, while the MIX-M exhibited both antiangiogenic and apoptotic induction that results in significant tumor volume reduction. Based on our results, MIX-M micelles can be utilized to achieve synergistic apoptotic and anti-angiogenic effects when treated at frequent low doses.

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Recent advances in polymeric micelles for anti-cancer drug delivery

Cited by 409 publications

References 183 publications

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

Intracellular “activated” two-photon photodynamic therapy by fluorescent conveyor and photosensitizer co-encapsulating pH-responsive micelles against breast cancer

Combinatorial Polymeric Conjugated Micelles with Dual Cytotoxic and Antiangiogenic Effects for the Treatment of Ovarian Cancer

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Recent advances in polymeric micelles for anti-cancer drug delivery

Cited by 409 publications

References 183 publications

Ascorbyl palmitate/d-&alpha;-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

Ascorbyl palmitate/d-&alpha;-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

Intracellular &ldquo;activated&rdquo; two-photon photodynamic therapy by fluorescent conveyor and photosensitizer co-encapsulating pH-responsive micelles against breast cancer

Combinatorial Polymeric Conjugated Micelles with Dual Cytotoxic and Antiangiogenic Effects for the Treatment of Ovarian Cancer

Contact Info

Product

Resources

About

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo

Intracellular “activated” two-photon photodynamic therapy by fluorescent conveyor and photosensitizer co-encapsulating pH-responsive micelles against breast cancer