Ultrasound-targeted photodynamic and gene dual therapy for effectively inhibiting triple negative breast cancer by cationic porphyrin lipid microbubbles loaded with HIF1α-siRNA

Sun, Shaodong; Xu, Yunxue; Fu, Peng; Chen, Min; Sun, Shijie; Zhao, Rongjun; Wang, Jinrui; Liang, Xiaolong; Wang, Shumin

doi:10.1039/c8nr03074j

Cited by 77 publications

(32 citation statements)

References 30 publications

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“…Another exciting development in the realm of enhanced US‐guided PDT came from the research of Sun et al ., in which they combined US‐targeted PDT with gene therapy to treat triple‐negative breast cancer. They achieved this goal by using cationic porphyrin lipid microbubbles loaded with HIF1alpha‐siRNA, providing a therapeutic with both enhanced contrast and the added element of interfering with tumor function on the level of the transcriptome . The complexities of gene expression provide a multitude of therapeutic targets, from transcription factors (TF) and miRNA‐mediated transcriptional up‐ or downregulation , to cis‐ and transchromosomal long noncoding RNA (lncRNA) bridges, , all of which contribute to the proteomic profiles and organellar architecture of a cell .…”

Section: Theranostic Nanomaterials For Image‐guided Pdtmentioning

confidence: 99%

Role of Ultrasound and Photoacoustic Imaging in Photodynamic Therapy for Cancer

Hester

Kuriakose

Nguyen

et al. 2020

Photochem & Photobiology

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Photodynamic therapy (PDT) is a phototoxic treatment with high spatial and temporal control and has shown tremendous promise in the management of cancer due to its high efficacy and minimal side effects. PDT efficacy is dictated by a complex relationship between dosimetry parameters such as the concentration of the photosensitizer at the tumor site, its spatial localization (intracellular or extracellular), light dose and distribution, oxygen distribution and concentration, and the heterogeneity of the inter‐ and intratumoral microenvironment. Studying and characterizing these parameters, along with monitoring tumor heterogeneity pre‐ and post‐PDT, provides essential data for predicting therapeutic response and the design of subsequent therapies. In this review, we elucidate the role of ultrasound (US) and photoacoustic imaging in improving PDT‐mediated outcomes in cancer—from tracking photosensitizer uptake and vascular destruction, to measuring oxygenation dynamics and the overall evaluation of tumor responses. We also present recent advances in multifunctional theranostic nanomaterials that can improve either US or photoacoustic imaging contrast, as well as deliver photosensitizers specifically to tumors. Given the wide availability, low‐cost, portability and nonionizing nature of US and photoacoustic imaging, together with their capabilities of providing multiparametric morphological and functional information, these technologies are thusly inimitable when deployed in conjunction with PDT.

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Section: Theranostic Nanomaterials For Image‐guided Pdtmentioning

confidence: 99%

Role of Ultrasound and Photoacoustic Imaging in Photodynamic Therapy for Cancer

Hester

Kuriakose

Nguyen

et al. 2020

Photochem & Photobiology

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“…Sun et al [180] designed a multifunctional compound (siHIF@CpMB) constituted by cationic porphyrin lipip microbubbles (CpMBs), elaborated from cationic porphyrin lipip NPs, and loading HIF-1α siRNA (siHIF) on the surface by electronic adsorption. In vitro in MDA-MB-231 cells, the authors observed an efficient release of siHIF after ultrasound exposure (1.03 MHz, 50 % duty, 1 W•cm −2 , 1 min) and production of 1 O 2 after irradiation (650 nm, 200 mW•cm −2 , 10 min).…”

Section: Hif-1α Inhibitorsmentioning

confidence: 99%

Fighting Hypoxia to Improve PDT

et al. 2019

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Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for oxygen to induce a photodynamic effect. Tumours often have low oxygen concentrations, related to the abnormal structure of the microvessels leading to an ineffective blood distribution. Moreover, PDT consumes O2. In order to improve the oxygenation of tumour or decrease hypoxia, different strategies are developed and are described in this review: 1) The use of O2 vehicle; 2) the modification of the tumour microenvironment (TME); 3) combining other therapies with PDT; 4) hypoxia-independent PDT; 5) hypoxia-dependent PDT and 6) fractional PDT.

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“…In another recent study by Liang and Wang et al., HIF‐1α siRNA was loaded into a cationic porphyrin‐grafted lipid microbubble. The microbubbles can be efficiently converted into nanoparticles in situ under ultrasound treatment, which facilitates the accumulation of photosensitizer and siRNA at the tumor site through the cavitation effect 34 . HIF‐1α siRNA in this system can downregulate the hypoxia‐induced HIF‐1α level and enhance the PDT against triple‐negative breast cancer.…”

Section: Ameliorating Tumor Hypoxiamentioning

confidence: 99%

Application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia

Pan

et al. 2020

VIEW

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Photodynamic therapy (PDT), an oxygen‐dependent modality, has been clinically approved and is considered a promising approach for cancer treatment. However, PDT shows noticeable limits due to the hypoxic nature of most solid tumor microenvironments. In recent years, various strategies have been developed to overcome tumor hypoxia either via oxygen‐replenishing approaches or via diminishing oxygen dependence. Both of these approaches have shown promise in reversing hypoxia‐relevant PDT resistance and thus improve antitumor efficacy. However, the low oxygen level at the tumor site is also an opportunity for the development of new therapeutic modalities, such as hypoxia‐activated chemotherapy, hypoxia‐inducible drug release, and starvation therapy. Therefore, a combination of these therapeutic modalities with PDT could promote their synergetic efficacy. Herein, we present an overview of the recent trend in the modulation and utilization of tumor hypoxia via nanomedicine‐based strategies, followed by a summary of the design and mechanisms of these nanosystems to improve PDT. Finally, current challenges and future perspectives for how PDT can achieve more extensive clinical applications for cancer therapy are discussed.

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Ultrasound-targeted photodynamic and gene dual therapy for effectively inhibiting triple negative breast cancer by cationic porphyrin lipid microbubbles loaded with HIF1α-siRNA

Abstract: Enhanced PDT and siRNA transfection effect of siRNA@CpMBs were successfully achieved by in situ conversion of MBs to NPs.

Cited by 77 publications

References 30 publications

Role of Ultrasound and Photoacoustic Imaging in Photodynamic Therapy for Cancer

Role of Ultrasound and Photoacoustic Imaging in Photodynamic Therapy for Cancer

Fighting Hypoxia to Improve PDT

Application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia

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