Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice

Yi, Shasha; Zou, Junjie; Meng, Long; Chen, Hou-minji; Hong, Zhong-qiu; Liu, Xiufang; Farooq, Umar; Chen, Mo-xian; Lin, Zhengrong; Zhou, Wei; Li, Ao; Hu, Xiquan; Niu, Lili

doi:10.3389/fpsyt.2022.864481

Cited by 21 publications

(17 citation statements)

References 72 publications

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“…The EPM test is another specific experimental paradigm for examining the state of anxiety in mice ( 30 , 31 ). The EPM is composed of a pair of opposite open arms (35 cm × 5 cm) and a pair of opposite closed arms (35 cm × 5 cm × 15 cm) and a central area, which cross each other in a cross shape.…”

Section: Methodsmentioning

confidence: 99%

Restraint stress induced anxiety and sleep in mice

et al. 2023

Front. Psychiatry

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In humans and animals, exposure to changes in internal or external environments causes acute stress, which changes sleep and enhances neurochemical, neuroendocrine, and sympathetic activities. Repeated stress responses play an essential role in the pathogenesis of psychiatric diseases and sleep disorders. However, the underlying mechanism of sleep changes and anxiety disorders in response to acute stress is not well established. In the current study, the effects of restraint stress (RS) on anxiety and sleep–wake cycles in mice were investigated. We found that after RS, the mice showed anxiety-like behavior after RS manipulation and increased the amounts of both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep in the dark period. The increase in sleep time was mainly due to the increased number of episodes of NREM and REM sleep during the dark period. In addition, the mice showed an elevation of the EEG power spectrum of both NREM and REM sleep 2 h after RS manipulation. There was a significant reduction in the EEG power spectrum of both NREM and REM sleep during the darkperiod in the RS condition. The expression of the c-Fos protein was significantly increased in the parabrachial nucleus, bed nucleus of the stria terminalis, central amygdala, and paraventricular hypothalamus by RS manipulation. Altogether, the findings from the present study indicated that neural circuits from the parabrachial nucleus might regulate anxiety and sleep responses to acute stress, and suggest a potential therapeutic target for RS induced anxiety and sleep alterations.

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Section: Methodsmentioning

confidence: 99%

Restraint stress induced anxiety and sleep in mice

et al. 2023

Front. Psychiatry

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“…Ultrasound pulse signals were generated by a signal generator (DG4162, RIGOL, Beijing, China). Pulse signals were amplified through a power amplifier (LZY‐22+, MiniCircuits, Brooklyn, NY), and then transmitted to an ultrasound transducer (diameter = 20 mm, focal distance = 19 mm) (1905055, ndtXducer, Northborough, MA) with 1.0 MHz fundamental frequency 32 . The details of the focused transducer parameters shown in Figure S1.…”

Section: Methodsmentioning

confidence: 99%

“…Pulse signals were amplified through a power amplifier (LZY-22+, MiniCircuits, Brooklyn, NY), and then transmitted to an ultrasound transducer (diameter = 20 mm, focal distance = 19 mm) (1905055, ndtXducer, Northborough, MA) with 1.0 MHz fundamental frequency. 32 The details of the focused transducer parameters shown in Figure S1. The ultrasound parameters were generally carried out as described by the previous study and as shown in Figure 1B 30 : Anesthesia was induced in animals with 5% isoflurane and then maintained with 1.5 to 2% isoflurane through a face mask.…”

Section: Low-intensity Focused Ultrasoundmentioning

confidence: 99%

Low‐Intensity Focused Ultrasound Ameliorates Ischemic Heart Failure Related to the Cholinergic Anti‐Inflammatory Pathway

Zhong

Cai

Zhong

et al. 2022

J of Ultrasound Medicine

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Objectives-This study aims to determine the effect of low-intensity focused ultrasound (LIFU) in ischemic heart failure (IHF) and explore the potential neuroimmune mechanism.Methods-Sprague-Dawley rats were subjected to ultrasound (US) with specific parameters, and electrocardiograms were recorded to analyze the effect of LIFU and/or vagal denervation on heart rate. Thereafter, myocardial infarction (MI) was induced by left anterior artery ligation, and LIFU was performed three times a day for 25 days after MI. Echocardiography, Masson staining, and ELISA were used to evaluate the effect of LIFU on the structure and function of the heart. Finally, ELISA, flow cytometry, qRT-PCR, and Western blot analysis were performed to determine the effect of LIFU on the inflammation and the expression of the cholinergic anti-inflammatory pathway (CAP)-related mediators.Results-LIFU reduced heart rate in rats (control vs LIFU, P < .01), and vagotomy (VT) eliminated this effect of LIFU on heart rate (VT vs LIFU + VT, P > .01). LIFU-ameliorated IHF in terms of cardiac structure and function (MI vs MI + LIFU, P < .01), but VT abrogated the beneficial effect of LIFU (MI + VT vs MI + LIFU + VT, P > .01). After the treatment of LIFU, decreased levels of inflammatory cytokines, increased proportion of antiinflammatory macrophages, and increased expression of CAP-related mediators (MI vs MI + LIFU, P < .01).Conclusions-LIFU ameliorates IHF whereas the CAP plays a promising role. LIFU has the potential to be a novel nonpharmacological and noninvasive therapy for the treatment of coronary artery disease and other cardiovascular diseases.

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“…Sha-Sha Yi et al recently found that LIFUS can alleviate the behaviors of lipopolysaccharide-induced depressed mice. Moreover, the lipopolysaccharide-mediated upregulation of inflammatory cytokines was significantly reduced by LIFUS ( 95 ). As in other neurological disorders, the therapeutic effects of some drugs and other factors on depression are limited by the intrinsic properties of the BBB.…”

Section: Ultrasonic Stimulation In Central Nervous System Diseasementioning

confidence: 99%

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

Ye²,

Liang³

et al. 2023

Front. Neurol.

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Transcranial ultrasound stimulation is a neurostimulation technique that has gradually attracted the attention of researchers, especially as a potential therapy for neurological disorders, because of its high spatial resolution, its good penetration depth, and its non-invasiveness. Ultrasound can be categorized as high-intensity and low-intensity based on the intensity of its acoustic wave. High-intensity ultrasound can be used for thermal ablation by taking advantage of its high-energy characteristics. Low-intensity ultrasound, which produces low energy, can be used as a means to regulate the nervous system. The present review describes the current status of research on low-intensity transcranial ultrasound stimulation (LITUS) in the treatment of neurological disorders, such as epilepsy, essential tremor, depression, Parkinson's disease (PD), and Alzheimer's disease (AD). This review summarizes preclinical and clinical studies using LITUS to treat the aforementioned neurological disorders and discusses their underlying mechanisms.

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Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice

Cited by 21 publications

References 72 publications

Restraint stress induced anxiety and sleep in mice

Restraint stress induced anxiety and sleep in mice

Low‐Intensity Focused Ultrasound Ameliorates Ischemic Heart Failure Related to the Cholinergic Anti‐Inflammatory Pathway

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

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