Ultrasound-Stimulated Microbubbles Enhance Radiation-Induced Cell Killing

McCorkell, Giulia; Nakayama, Masao; Feltis, Bryce; Piva, Terrence J.; Geso, Moshi

doi:10.1016/j.ultrasmedbio.2022.07.001

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…32,40 Because of the broad application of FUS, many studies have investigated its implementation in, but not limited to, the opening of the blood-brain barrier, 41,44 neuromodulation, 45,47 enhancing chemotherapy drug delivery, 48,50 immunomodulation, 51,54 and enhancing RT response. 55,58 Focused Ultrasound and Radiation Therapy…”

Section: Focused Ultrasoundmentioning

confidence: 99%

Focused Ultrasound and Ultrasound Stimulated Microbubbles in Radiotherapy Enhancement for Cancer Treatment

Leong

Sharma

Czarnota

2023

Technol Cancer Res Treat

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Radiation therapy (RT) has been the standard of care for treating a multitude of cancer types. However, ionizing radiation has adverse short and long-term side effects which have resulted in treatment complications for decades. Thus, advances in enhancing the effects of RT have been the primary focus of research in radiation oncology. To avoid the usage of high radiation doses, treatment modalities such as high-intensity focused ultrasound can be implemented to reduce the radiation doses required to destroy cancer cells. In the past few years, the use of focused ultrasound (FUS) has demonstrated immense success in a number of applications as it capitalizes on spatial specificity. It allows ultrasound energy to be delivered to a targeted focal area without harming the surrounding tissue. FUS combined with RT has specifically demonstrated experimental evidence in its application resulting in enhanced cell death and tumor cure. Ultrasound-stimulated microbubbles have recently proved to be a novel way of enhancing RT as a radioenhancing agent on its own, or as a delivery vector for radiosensitizing agents such as oxygen. In this mini-review article, we discuss the bio-effects of FUS and RT in various preclinical models and highlight the applicability of this combined therapy in clinical settings.

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Section: Focused Ultrasoundmentioning

confidence: 99%

Focused Ultrasound and Ultrasound Stimulated Microbubbles in Radiotherapy Enhancement for Cancer Treatment

Leong

Sharma

Czarnota

2023

Technol Cancer Res Treat

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“…Recently, ultrasound is also explored in the combat against pathogenic microorganisms and drug-resistant bacteria [ 26 , 27 , 28 , 29 , 30 , 31 ]. In the majority of studies, low-frequency or focused ultrasonic radiation of high intensity is used [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among the serious drawbacks of such an approach are the side effects and the necessity of rather expensive equipment, which should be able to generate shock waves [ 27 ]. Several routes to synergistic antibacterial effect comprising the utilization of antibiotic drugs, microbubbles and ultrasound treatment were suggested as well [ 28 , 29 ]. Low-intensity medical ultrasound and SDT can also be applied as effective tools against microorganisms, including the treatment of superficial and deep-seated microbial infections [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Effect of Acoustic Cavitation Promoted by Mesoporous Silicon Nanoparticles

Sviridov

Mazina

Ostapenko

et al. 2023

IJMS

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As-prepared mesoporous silicon nanoparticles, which were synthesized by electrochemical etching of crystalline silicon wafers followed by high-energy milling in water, were explored as a sonosensitizer in aqueous media under irradiation with low-intensity ultrasound at 0.88 MHz. Due to the mixed oxide-hydride coating of the nanoparticles’ surfaces, they showed both acceptable colloidal stability and sonosensitization of the acoustic cavitation. The latter was directly measured and quantified as a cavitation energy index, i.e., time integral of the magnitude of ultrasound subharmonics. The index turned out to be several times greater for nanoparticle suspensions as compared to pure water, and it depended nonmonotonically on nanoparticle concentration. In vitro tests with Lactobacillus casei revealed a dramatic drop of the bacterial viability and damage of the cells after ultrasonic irradiation with intensity of about 1 W/cm2 in the presence of nanoparticles, which themselves are almost non-toxic at the studied concentrations of about 1 mg/mL. The experimental results prove that nanoparticle-sensitized cavitation bubbles nearby bacteria can cause bacterial lysis and death. The sonosensitizing properties of freshly prepared mesoporous silicon nanoparticles are beneficial for their application in mild antibacterial therapy and treatment of liquid media.

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Numerical Prediction of Size Distribution of Microbubbles in Water With Mass Transfer

Li,

Hosokawa,

Hayashi

et al. 2024

MultScienTechn

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It has been reported that the diameter and the number density of microbubbles would change in time due to mass transfer between bubbles and surrounding liquid. However, few numerical studies have been conducted on the time evolution of diameters of single microbubbles or groups of microbubbles due to mass transfer. Numerical simulations based on the Rayleigh-Plesset equation were therefore carried out to investigate the time evolution of bubble diameter and the mass transfer of dissolved gas between bubbles and water in microbubble flow in a duct. As a result, the following conclusions were obtained: (1) the present numerical method can accurately predict the growth and shrinkage of a single microbubble. (2) Microbubbles in a flow usually have size distribution, in which bubbles larger and smaller than the equilibrium diameter become larger and smaller in time, respectively. Thus, the size distribution changes in time. (3) The proposed numerical method can reasonably predict time evolutions of bubble size distributions, void fractions, and concentrations of dissolved gas, provided that a reliable initial condition is available.

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Ultrasound-Stimulated Microbubbles Enhance Radiation-Induced Cell Killing

Cited by 6 publications

References 35 publications

Focused Ultrasound and Ultrasound Stimulated Microbubbles in Radiotherapy Enhancement for Cancer Treatment

Focused Ultrasound and Ultrasound Stimulated Microbubbles in Radiotherapy Enhancement for Cancer Treatment

Antibacterial Effect of Acoustic Cavitation Promoted by Mesoporous Silicon Nanoparticles

Numerical Prediction of Size Distribution of Microbubbles in Water With Mass Transfer

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