Ultrasound/radiation-responsive emulsions

X-ray-responsive prodrugs and polymeric nanocarriers for multimodal cancer therapy

“…23,[25][26][27] X-ray-responsive polymeric nanoparticles can afford a unique platform for the integration of chemotherapy during radiotherapy. 10,34,35 The radiationsensitive strategies not only improve spatial and temporal controllability but also have the capacity to release exclusively at the tumour site. At present, radiotherapy along with X-raytriggered multimodal cancer therapy is gradually achieving better tumoricidal effects.…”

Improved hybrid-shelled perfluorocarbon microdroplets as ultrasound- and laser-activated phase-change platform

“…Microdroplets (MDs) with a liquid perfluorocarbon (PFC) core exposed to either an ultrasound field or an optical stimulus can transform into microbubbles (MBs) by the processes known as Acoustic (ADV) or Optical Droplet Vaporisation (ODV), respectively [1][2][3][4][5][6][7]. Thanks to the acoustic response of the MBs formed after vaporisation, MDs represent "phase-change" ultrasound or photoacoustic contrast agents suitable for enhancing the imaging contrast of pathological areas or even for tracking at high frame rate the dynamics in blood flows [5][6][7][8][9]. Recent literature has also shown that droplet vaporisation could be exploited in various medical treatments, mainly focused on the vascular system, to boost targeted drug delivery [10][11][12].…”

“…For in vivo use, the smallest MDs size achievable is desirable in order to reach the thinner capillaries, whose typical lumen is 5-10 µm, without causing their occlusion. Despite several MDs formulations have been proposed in recent years, a synthesis protocol that accomplishes this requirement and produces MDs with good yield is still lacking to date [4,7,14,15].…”

Numerical study of the effect of liquid compressibility on acoustic droplet vaporization

“…Acoustic droplet vaporization (ADV) is emerging in the field of non-invasive targeted therapy and diagnosis, as reviewed in Refs. [1] , [2] . Nanodroplets are vaporized into microbubbles when the amplitude of ultrasonic pulses exceeds a certain intensity called ADV threshold.…”