Numerical study of the effect of liquid compressibility on acoustic droplet vaporization

Abstract

In acoustic droplet vaporization (ADV), a cavitated bubble grows and collapses depending on the pressure amplitude of the acoustic pulse. During the bubble collapse, the surrounding liquid is compressed to high pressure, and liquid compressibility can have a significant impact on bubble behavior and ADV threshold. In this work, a one-dimensional numerical model considering liquid compressibility is presented for ADV of a volatile microdroplet, extending our previous Rayleigh-Plesset based model [Ultrason. Chem. 71 (2021) 105361]. The numerical results for bubble motion and liquid energy change in ADV show that the liquid compressibility highly inhibits bubble growth during bubble collapse and rebound, especially under high acoustic frequency conditions. The liquid compressibility effect on the ADV threshold is quantified with varying acoustic frequencies and amplitudes.

Numerical investigation of two-microbubble collapse and cell deformation in an ultrasonic field

“…S4 of the Supplementary information . The peak of the shock pressure decreases nearly proportional to [5] . Strong pressure is applied to the upper surface of the cell, causing rapid deformation, but its influence on the cell deformations is not significant, as seen in Fig.…”

“…The liquid incompressibility appears to have little influence on the bubble growth and cell deformation during bubble expansion and contraction. However, the bubble re-expands larger than in the compressible liquid case because the loss of liquid kinetic energy, which is caused by the shock wave emission during bubble collapse and re-expansion, is not considered [5] . The incompressible liquid case also does not take into account the ultrasonic wave propagation, resulting in more spherical bubble collapse as well as reduced cell deformation.…”

“… [2] , [3] . Fundamental studies have also been reported on ultrasound-driven droplet vaporization [4] , [5] , acoustic cavitation with non-condensable bubble nuclei [6] , and bubble oscillation on a rigid boundary [7] , [8] , [9] .…”

Tumor-penetrating nanoplatform with ultrasound “unlocking” for cascade synergistic therapy and visual feedback under hypoxia

“…Nanoultrasonic biomedicines, including low-diffusion liquid perfluorocarbon (PFC)-based nanodroplets, have been designed for US-activated specific drug release, molecular imaging, SDT, etc [18][19][20][21][22]. Moreover, after US activation, the nanodroplets reach a certain threshold; thus, a large amount of liquid PFC is converted into a gaseous state, and a final rupture occurs due to vibration and expansion, resulting in an ultrasonic cavitation effect, which is also known as acoustic droplet vaporization (ADV), to achieve highly selective drug release and responsive imaging in a pathological tissue [23,24]. Additionally, various formulations of liquid PFC, which have been reported to carry more than 1.5 times more O 2 than blood (25 °C, 1 atm), have been extensively explored as artificial blood substitutes [25,26].…”

Ultrasound‐assisted production of alcoholic beverages: From fermentation and sterilization to extraction and aging

“…During ultrasonication, the acoustic wave propagates through the medium and compresses and decompresses its particles, that is, rarefaction. As a result, turbulence and increased mass transfer cause much energy to be produced in liquor samples (Park & Son, 2021). The US technology is an eco‐friendly, low‐cost, high‐efficient, rapidly emerging food processing technology that accelerates and optimizes a variety of agri‐food processes (Bhargava et al., 2021).…”