Ultrasound propagation in ‘in vivo’ bone

Behari, J.; Singh, Surendra

doi:10.1016/0041-624x(81)90114-1

Cited by 23 publications

(8 citation statements)

References 16 publications

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“…Ultrasound produces physiological mechanical stress in the bone that causes its deformation. This deformation causes the generation of potential differences in the cells which causes bone remodelling [43]. Low intensity ultrasound produces nonthermal effect which causes stable cavitation, microstreaming, and mechanical effect on the cell membrane [44].…”

Section: Discussionmentioning

confidence: 99%

Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study

Kaur

Uludağ

El‐Bialy

2014

BioMed Research International

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Objective. Basic fibroblast growth factor (bFGF) is an important regulator of tissue growth. Previous studies have shown that low intensity pulsed ultrasound (LIPUS) stimulates bone growth. The objective of this study was to evaluate the possible synergetic effect of LIPUS and local injection of nonviral bFGF plasmid DNA (pDNA) on mandibular growth in rats. Design. Groups were control, blank pDNA, bFGF pDNA, LIPUS, and bFGF pDNA + LIPUS. Treatments were performed for 28 days. Significant increase was observed in mandibular height and condylar length in LIPUS groups. MicroCT analysis showed significant increase in bone volume fraction in bFGF pDNA + LIPUS group. Histomorphometric analysis showed increased cell count and condylar proliferative and hypertrophic layers widths in bFGF pDNA group. Results. Current study showed increased mandibular condylar growth in either bFGF pDNA or LIPUS groups compared to the combined group that showed only increased bone volume fraction. Conclusion. It appears that there is an additive effect of bFGF + LIPUS on the mandibular growth.

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Section: Discussionmentioning

confidence: 99%

Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study

Kaur

Uludağ

El‐Bialy

2014

BioMed Research International

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“…Second, US waves cause mechanical pressure on the cell surface, which could activate the stretch receptors of cation channels on the cell membrane and affect intracellular gene expression . Third, since bone has the ability to remodel depending on functional demands, the mechanical stresses produced by low‐intensity pulsed US could help in remodeling of the bone microarchitecture …”

Section: Discussionmentioning

confidence: 99%

Effect of Increasing Low-Intensity Pulsed Ultrasound and a Functional Appliance on the Mandibular Condyle in Growing Rats

et al. 2016

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Objectives-Functional appliances are used for treatment of lower-jaw deficiencies in growing individuals; however, their effectiveness is debatable. Low-intensity pulsed ultrasound (US) is a noninvasive method, which has been shown to stimulate cartilage and bone formation with 20 minutes of application. This study was designed to test the hypothesis that increasing low-intensity pulsed US application from 20 to 40 min/d will enhance mandibular condylar growth in growing rats, especially when combined with a functional appliance.Methods-Fifty-four Sprague Dawley rats were divided into 6 groups (n 5 9): control, low-intensity pulsed US for 20 minutes, low-intensity pulsed US for 40 minutes, the functional appliance, the functional appliance plus low-intensity pulsed US for 20 minutes, and the functional appliance plus low-intensity pulsed US for 40 minutes. Low-intensity pulsed US was applied for 28 days. All rats were then euthanized, and their mandibles were dissected for morphometric, histomorphometric, and micro-computed tomographic analyses.Results-Among all study groups, the 20-minute US group showed significant increases in most of the measured variables (P < .05) except for condylar process length (P 5 .18), whereas the functional appliance-plus-40-min US group showed the least favorable results. The 20-minute US group showed increases in proliferative and hypertrophic cell counts and widths and enhanced microarchitecture of trabecular bone compared with the 40-minute US group. The functional appliance-plus-20-minute US group showed better results compared with the functional appliance-alone and functional appliance-plus-40-minute US groups.Conclusions-A daily application of low-intensity pulsed US for 20 minutes in growing rats affects mandibular growth, either alone or in combination with a functional appliance. Further study with a longer observation period is required to study the long-term effects and stability of newly formed bone.

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“…Ultrasound is a biophysical intervention that is capable of generating piezo-electric effects in bone (Behari and Singh, 1981), and increasing electric potentials in bone (Klug, 1983). Using 1.27-MHz ultrasound with a very low intensity of 0.00383 W cm -2 on bone, Behari and Singh (1981) measured an electric potential of 64 V at the ultrasound frequency in vivo. In a 21-day-old rabbit tibial fracture, there is an increase in callus potential of 0.9 mV during application of 880-kHz low-intensity ultrasound of 0.01 W cm -2 (Klug, 1983).…”

Section: Piezo-electric Effectsmentioning

confidence: 99%

Ultrasound Stimulation of Maxillofacial Bone Healing

Schortinghuis¹,

Stegenga²,

Raghoebar³

et al. 2003

Critical Reviews in Oral Biology & Medicine

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A substantial part of the maxillofacial surgery practice deals with maxillofacial bone healing. In the past decades, low-intensity ultrasound treatment has been shown to reduce the healing time of fresh fractures of the extremities up to 38%, and to heal delayed and non-unions up to 90% and 83%, respectively. Based on the assumption that the process of bone healing in the bones of the extremities and maxillofacial skeleton is essentially the same, the potential of ultrasound to stimulate maxillofacial bone healing was investigated. Although limited evidence is available to support the susceptibility of maxillofacial bone to the ultrasound signal, ultrasound may be of value in the treatment of delayed unions, in callus maturation after distraction, and in the treatment of osteoradionecrosis.

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Ultrasound propagation in ‘in vivo’ bone

Cited by 23 publications

References 16 publications

Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study

Effect of Nonviral Plasmid Delivered Basic Fibroblast Growth Factor and Low Intensity Pulsed Ultrasound on Mandibular Condylar Growth: A Preliminary Study

Effect of Increasing Low-Intensity Pulsed Ultrasound and a Functional Appliance on the Mandibular Condyle in Growing Rats

Ultrasound Stimulation of Maxillofacial Bone Healing

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