Ultrasound promoted synthesis of some novel fused pyrans

Abstract

Novel fused pyrans were synthesized from the reaction of the tetrahydropyran-4-one with arylidine malononitriles. Different fused pyran derivatives were obtained from the mentioned reaction depending on type of catalyst used and type of energy used. Reactions were carried out under silent and ultrasonic conditions. In general, it was found that sometimes ultrasound irradiations change the reaction path in comparing with silent condition. In addition to improvement in reaction times, the products were obtained in high yields and their structures were determined by elemental analyses, spectral data.

Use of Ultrasound in the Synthesis of Heterocycles of Medicinal Interest

“…Recently, Saleh et al [127] have synthesized different fused pyran derivatives (188) from the reaction of tetrahydropyran-4-one (186) with arylidine malononitriles (187) (Scheme 49). Recently, Saleh et al [127] have synthesized different fused pyran derivatives (188) from the reaction of tetrahydropyran-4-one (186) with arylidine malononitriles (187) (Scheme 49).…”

“…SCHEME 32 Synthesis of 6-chloro-5-formyl-1,4-dihydropyridines(127). SCHEME 32 Synthesis of 6-chloro-5-formyl-1,4-dihydropyridines(127).…”

Ultrasonics Promoted Synthesis of 5-(Pyrazol-4-yl)-4,5-Dihydropyrazoles Derivatives

“…Compared with traditional methods, this method is more convenient and easily controlled. A large number of organic reactions can be carried out in a higher yield shorter reaction time and milder conditions under ultrasound [48][49][50][51][52].…”

Green Synthesis, Antimicrobial Activity and Cytotoxicity of Novel Fused Pyrimidine Derivatives Possessing a Trifluoromethyl Moiety

“…Motivated by the aforementioned findings, and in a continuation of our interest in the synthesis of a wide range of heterocyclic systems, for biological screening in our laboratory utilizing green chemistry tools . We report here the reaction of E ‐3‐(dimethylamino)1‐(4‐(trifluoromethyl)phenyl)prop‐2‐en‐1‐one (1) with a series of different nitrogen‐based nucleophiles under solvent free mechanochemical condition utilizing nanosized magnesium oxide catalyst.…”