Green Synthesis, Antimicrobial Activity and Cytotoxicity of Novel Fused Pyrimidine Derivatives Possessing a Trifluoromethyl Moiety

Al‐Bogami, Abdullah S.; Saleh, Tamer S.; Moussa, Tarek A. A.

doi:10.1002/slct.201801050

Cited by 16 publications

(11 citation statements)

References 29 publications

(35 reference statements)

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“…[62][63][64] Most of these studies have been focused on developing alternative synthetic routes to marketed APIs, for which the benefit-risk balance was already known, [9b, 65,66] and therefore the mechanochemical procedures were preordained to provide products previously regarded as safe. However, in some cases, newly mechanosynthesized molecules and pharmaceutical solid forms have been studied to determine their biological activity, [67][68][69][70][71][72] toxicity, [73,74] and stability. [75][76][77] For example, a recent work focused on developing a ball milling route to access Cu II metallodrugs [Cu(HMeI) 2 (solvent)x; HMel = meloxicam; solvent = DMF, DMSO, H 2 O] revealed that mechanochemistry had led to the formation of a novel Cu II complex of octahedral geometry instead of the typical square-pyramidal complex obtained in solution.…”

Section: Gc 4: Designing Safer Chemicalsmentioning

confidence: 99%

Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

2021

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In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis. In addition to their efficiency and practicality, mechanochemical reactions are also recognized for their sustainability. The association between mechanochemistry and Green Chemistry often originates from the solvent-free nature of most mechanochemical protocols, which can reduce waste production. However, mechanochemistry satisfies more than one of the Principles of Green Chemistry. In this Review we will present a series of examples that will clearly illustrate how mechanochemistry can significantly contribute to the fulfillment of Green Chemistry in a more holistic manner.

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Section: Gc 4: Designing Safer Chemicalsmentioning

confidence: 99%

Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

2021

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“…This method is devoid of the use of other harmful/toxic organic solvents and follows an environmentally benign protocol resulting in easy and feasible access to develop novel polysubstituted azoloazine derivatives. [33] Here, it is noteworthy to mention that the group was able to carry out the characterization of the synthesized molecules using HMBC 1H-15N NMR technique, confirming the formation of regioisomers, and it was characterized unambiguously. This characterization technique was much more feasible than the conventional single-crystal X-ray diffraction crystallography as these types of compounds had a large number of regioisomers.…”

Section: Synthesis Of Pyrazolopyrimidines Under Solvent-free Conditionsmentioning

confidence: 83%

Efficient Green Protocols for the Preparation of Pyrazolopyrimidines

et al. 2021

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Pyrazolopyrimidine with all its isoforms occupy a noteworthy position in medicinal chemistry owing to their proven dominance in the modulation of a vast array of biological receptors, thereby mitigating numerous pathological conditions. The development of sustainable protocols, which integrate the principles of green chemistry in the synthesis process although challenging, offers the most appropriate way to conduct the sustainable synthesis of pyrazolopyrimidines. Due to the effectiveness of this nucleus and striking similarity to purines, they have been accessed using green as well as non-green protocols. Analytical techniques like 2D NMR has been employed for the confirmation of pyrazolopyrimidines and their isomers besides the conventional single-crystal X-ray diffraction (XRD). Here, considering the rising awareness of sustainable protocols, we aimed at exploring this decade for green protocols for the synthesis of pyrazolopyrimidines and furnished products in excellent yields in this review. Protocols covered in this review include synthesis using green solvent, solvent-free conditions, green catalyst, and catalyst-free reactions. Also, synthesis of pyrazolopyrimidines assisted by microwave and ultrasound, as well as ionic liquid mediated synthesis are covered. It is estimated that this review shall throw some light upon the environmentally benign protocols to produce pyrazolopyrimidines which is itself a very important nucleus in the field of medicinal chemistry.

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“…To the best of our knowledge, few reports dealt with a heterogeneous catalyst system for this 1,4-conjugate addition [28][29][30]. Bearing in mind all of the abovementioned factors, we continued our interest in introducing a benign protocol for organic reactions utilizing heterogeneous catalysts [20,[31][32][33][34]. We introduce here a facile sonochemical synthesis for the conjugate addition of aryl halides onto electron-deficient olefins utilizing a CoMgAl LDH.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic-Assisted Michael Addition of Arylhalide to Activated Olefins Utilizing Nanosized CoMgAl-Layered Double Hydroxide Catalysts

et al. 2020

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An efficient cobalt-based layered double hydroxide (LDH)-catalyzed Michael addition of an aryl halide compound onto activated olefin as a Michael acceptor is described. The synthesized catalytic materials were characterized using different techniques to investigate their physicochemical, morphological, and textural properties. The partial isomorphic substitution of magnesium by cobalt ions in the cationic sheets of the layered double hydroxide (CoMgAl-LDH) appears to be an appropriate catalyst to cause this reaction. This technique enables compound synthesis resulting from the 1,4-addition in good to excellent yields. Moreover, ultrasound was found to have beneficial effect on this reaction due to the cavitation phenomenon.

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Green Synthesis, Antimicrobial Activity and Cytotoxicity of Novel Fused Pyrimidine Derivatives Possessing a Trifluoromethyl Moiety

Cited by 16 publications

References 29 publications

Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

Efficient Green Protocols for the Preparation of Pyrazolopyrimidines

Ultrasonic-Assisted Michael Addition of Arylhalide to Activated Olefins Utilizing Nanosized CoMgAl-Layered Double Hydroxide Catalysts

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