Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and β-enamino trihalomethyl ketones in water

Abstract

A convenient method for the preparation of 5-hydroxy-5-trihalo-4,5-dihydroisoxazoles and beta-enamino trihalomethyl ketones, from the reaction of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones with hydroxylamine and anilines, respectively, using water as solvent and under ultrasound irradiation is reported.

Antioxidant capacity and environmentally friendly synthesis of dihydropyrimidin‐(2H)‐ones promoted by naturally occurring organic acids

“…Recently, we described the synthesis of a variety of organic molecules under nontraditional conditions, such as in aqueous media with microwave or ultrasound irradiation 33–40. In the present work, we report an efficient and clean procedure for preparing DHPM by the use of citric acid or tartaric acid as a promoter of the Biginelli synthesis in ethanol as solvent.…”

Brönsted Acidic Ionic Liquids Catalysed Sequential Michael‐Like Addition of Indole with Chalcones via Claisen‐Schmidt Condensation

“…Their high non‐linear optical coefficients and good crystallizability make them appropriate candidates for applications in photonics and optoelectronics . They are also employed as reaction precursors to get pyrazoles, isoxazoles and thiazoles . The general synthetic routes of chalcones involving Claisen‐Schmidt condensation between acetophenone derivatives and aromatic aldehydes, utilize strong acidic or basic reagents/catalysts like NaOH, Ba(OH) 2 , KOH, AlCl 3 and HCl, which come with drawbacks of catalyst recovery, side product formation, less product selectivity, longer reaction time, extreme reaction conditions and complicated isolation of products .…”

A Facile and Green Synthesis of “5-(3-methyl-7-substituted-4H-1, 4-benzothiazin-2-yl)-4-aryl-4H-1, 2, 4-triazole-3-thiols” under Ultrasound Irradiation

“…However, the use of ultrasound in heterocyclic system is not fully explored. 10,11 In order to expand the application of ultrasound in the synthesis of heterocyclic compounds. We wish to report a general, efficient and eco-friendly method for the synthesis of 5-(3-methyl-7-substituted-4H-1, 4-benzothiazin-2-yl)-4-aryl-4H-1, 2, 4-triazole-3-thiols derivatives.…”