Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy

Tu, Jiawei; Zhang, Hui; Jia, Yu; Liufu, Chun; Chen, Zhiyi

doi:10.2147/ott.s171019

Cited by 37 publications

(35 citation statements)

References 100 publications

(111 reference statements)

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“…Thus, the limits of the active cavitation zone can be potentially quantified and optimised promoting effective cavitation treatment. Apart from metallurgical applications, the results of this study are of significance for applications in relevant scientific fields such as surface cleaning [76] , bacterial cleaning and water decontamination [77] , exfoliation of 2D nanomaterials [78] as well as tumour treatment [79] and medical lithotripsy [23] dealing with cavitation bubbles’ interaction with solid surfaces.…”

Section: Resultsmentioning

confidence: 99%

On the governing fragmentation mechanism of primary intermetallics by induced cavitation

Priyadarshi

Khavari

Subroto

et al. 2021

Ultrasonics Sonochemistry

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Section: Resultsmentioning

confidence: 99%

On the governing fragmentation mechanism of primary intermetallics by induced cavitation

Priyadarshi

Khavari

Subroto

et al. 2021

Ultrasonics Sonochemistry

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“…Acoustic cavitation, particularly inertial cavitation, plays an essential role in the anti-vascular effect elicited by USMB treatment (Lin et al, 2012;Liu et al, 2012), and acoustic pressure is among the most important parameters for inertial cavitation (Abbott, 1999;Tu et al, 2018). Based on these previous findings, when using an appropriate pressure, USMB therapy can result in substantial and persistent damage to tumor perfusion without damaging the surrounding normal tissue.…”

Section: Introductionmentioning

confidence: 97%

Improving the Therapeutic Effect of Ultrasound Combined With Microbubbles on Muscular Tumor Xenografts With Appropriate Acoustic Pressure

Wang

et al. 2020

Front. Pharmacol.

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Ultrasound combined with microbubbles (USMB) is a promising antitumor therapy because of its capability to selectively disrupt tumor perfusion. However, the antitumor effects of repeated USMB treatments have yet to be clarified. In this study, we established a VX2 muscular tumor xenograft model in rabbits, and performed USMB treatments at five different peak negative acoustic pressure levels (1.0, 2.0, 3.0, 4.0, or 5.0 MPa) to determine the appropriate acoustic pressure. To investigate whether repeated USMB treatments could improve the antitumor effects, a group of tumor-bearing rabbits was subjected to one USMB treatment per day for three consecutive days for comparison with the single-treatment group. Contrast-enhanced ultrasonic imaging and histological analyses showed that at an acoustic pressure of 4.0 MPa, USMB treatment contributed to substantial cessation of tumor perfusion, resulting in severe damage to the tumor cells and microvessels without causing significant effects on the normal tissue. Further, the percentages of damaged area and apoptotic cells in the tumor were significantly higher, and the tumor growth inhibition effect was more obvious in the multiple-treatment group than in the single USMB treatment group. These findings indicate that with an appropriate acoustic pressure, the USMB treatment can selectively destroy tumor vessels in muscular tumor xenograft models. Moreover, the repeated treatments strategy can significantly improve the antitumor effect. Therefore, our results provide a foundation for the clinical application of USMB to treat solid tumors using a novel therapeutic strategy.

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“…Microbubble destruction resulting from ultrasound induces an increase in capillary permeability and induces irreversible holes in target cell membranes, contributing to gene transfer into the nucleus and enhanced expression and transfection of the target gene (14). Additionally, gene transfer by UTMD can avoid degradation by lytic enzymes (15). The application of UTMD has been highlighted in cancer treatment, which greatly contributes to targeted cancer therapy (16).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer

et al. 2020

Exp Ther Med

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MicroRNAs (miRNAs/miRs) have important roles in tumor progression in various human cancers. Ultrasound-targeted microbubble destruction (UTMD)-mediated gene transfection has been considered a useful tool for improving cancer treatment. The present study aimed to investigate the role of miR-767 in non-small cell lung cancer (NSCLC) and further analyze the effects of UTMD-mediated miR-767 inhibition on tumor progression. The expression of miR-767 was measured by reverse transcription-quantitative PCR. UTMD-mediated miR-767 inhibition was achieved by the co-transfection of microbubbles and miR-767 inhibitor in NSCLC cells. Cell proliferation was assessed by a CCK-8 assay and cell migration and invasion were examined by a Transwell assay. The expression of miR-767 was increased in NSCLC serum, tissues and cells compared with controls. The reduction of miR-767 in NSCLC cells led to the inhibition of cell proliferation, migration and invasion. UTMD increased the transfection efficiency of the miR-767 inhibitor in NSCLC cells, and UTMD-mediated miR-767 inhibition resulted in a more significant suppressive effect on tumor cell proliferation, migration and invasion. Taken together, the results indicated that miR-767 expression is upregulated in both NSCLC clinical samples and cells. The downregulation of miR-767 can inhibit tumor cell proliferation, migration and invasion, and these effects are further promoted by UTMD-mediated miR-767 inhibition, which indicated the potential of a UTMD-mediated miR-767 inhibition as a novel therapeutic strategy for NSCLC treatment.

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Ultrasound-mediated microbubble destruction: a new method in cancer immunotherapy

Cited by 37 publications

References 100 publications

On the governing fragmentation mechanism of primary intermetallics by induced cavitation

On the governing fragmentation mechanism of primary intermetallics by induced cavitation

Improving the Therapeutic Effect of Ultrasound Combined With Microbubbles on Muscular Tumor Xenografts With Appropriate Acoustic Pressure

Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer

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