Ultrasound-mediated mesoporous silica nanoparticles loaded with PDLIM5 siRNA inhibit gefitinib resistance in NSCLC cells by attenuating EMT

Wu, Hao; Lv, Wenhao; Zhu, Yangyang; Jia, Yingying; Nie, Fang

doi:10.1016/j.ejps.2023.106372

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…High expression of PDLIM5 also promotes gefitinib resistance by inhibiting autophagy in PC9GR cells [137]. Knockdown of PDLIM5 through a novel mesoporous silica-loaded PDLIM5 siRNA (small interfering RNA) nanoplatform can reverse the gefitinib-resistant phenotype in PC9 [138].…”

Section: Pdlim4mentioning

confidence: 99%

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

Jiang,

Xu,

Jiang

et al. 2023

Cancers

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PDZ-LIM family proteins (PDLIMs) are a kind of scaffolding proteins that contain PDZ and LIM interaction domains. As protein–protein interacting molecules, PDZ and LIM domains function as scaffolds to bind to a variety of proteins. The PDLIMs are composed of evolutionarily conserved proteins found throughout different species. They can participate in cell signal transduction by mediating the interaction of signal molecules. They are involved in many important physiological processes, such as cell differentiation, proliferation, migration, and the maintenance of cellular structural integrity. Studies have shown that dysregulation of the PDLIMs leads to tumor formation and development. In this paper, we review and integrate the current knowledge on PDLIMs. The structure and function of the PDZ and LIM structural domains and the role of the PDLIMs in tumor development are described.

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Section: Pdlim4mentioning

confidence: 99%

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

Jiang,

Xu,

Jiang

et al. 2023

Cancers

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“…By restoring tumor-suppressor genes and introducing apoptotic genes, the combination of RNAi and chemotherapy drugs can augment chemotherapy in several ways. The codelivery of siR-NAs and anticancer drugs results in a synergistic impact; once the siRNA silences the targeted gene, drug efflux pumps reduce, thus allowing drug diffusion into cells across cell membranes [118][119][120][121][122] (Figure 4). Hence, the apoptotic process is accelerated, resulting in enhanced chemotherapeutic effects.…”

Section: Prevention Of Multiple-drug Resistancementioning

confidence: 99%

Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment

Xie,

Yue,

et al. 2023

Pharmaceutics

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Silencing genes using small interfering (si) RNA is a promising strategy for treating cancer. However, the curative effect of siRNA is severely constrained by low serum stability and cell membrane permeability. Therefore, improving the delivery efficiency of siRNA for cancer treatment is a research hotspot. Recently, mesoporous silica nanoparticles (MSNs) have emerged as bright delivery vehicles for nucleic acid drugs. A comprehensive understanding of the design of MSN-based vectors is crucial for the application of siRNA in cancer therapy. We discuss several surface-functionalized MSNs’ advancements as effective siRNA delivery vehicles in this paper. The advantages of using MSNs for siRNA loading regarding considerations of different shapes, various options for surface functionalization, and customizable pore sizes are highlighted. We discuss the recent investigations into strategies that efficiently improve cellular uptake, facilitate endosomal escape, and promote cargo dissociation from the MSNs for enhanced intracellular siRNA delivery. Also, particular attention was paid to the exciting progress made by combining RNAi with other therapies to improve cancer therapeutic outcomes.

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“…The large surface area empowered the MSNs heterostructure the competence to efficiently load photothermal agents Ag and chemotherapeutic agents Geb, which were pH-responsive drug release achieved by degradation of residual MnO 2 . 149 Wu et al 150 formulated a novel MSNs loaded with PDLIM5 siRNA. The results showed that PDLIM5 siRNA could be effectively bound to the nanoplatforms and had good biocompatibility.…”

Section: Nanosystems For Nsclc Treatment With/without Image Guidancementioning

confidence: 99%

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

et al. 2023

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Ultrasound-mediated mesoporous silica nanoparticles loaded with PDLIM5 siRNA inhibit gefitinib resistance in NSCLC cells by attenuating EMT

Cited by 7 publications

References 42 publications

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

PDZ and LIM Domain-Encoding Genes: Their Role in Cancer Development

Recent Advances in Mesoporous Silica Nanoparticles Delivering siRNA for Cancer Treatment

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

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