Ultrasound imaging in Peyronie disease

Imaging Modalities in Peyronie’s Disease

“…US has been suggested to give no additional information to clinical examination [22, 26], contrary to others [11, 27] who stated that US was an excellent method of assessing Peyronie’s disease. Amin et al’s [28] findings supported this view: They reviewed patients for erectile dysfunction with color doppler and duplex ultrasonography during pharmacologically induced erection and detected in the B-mode of the ultrasound image diffuse thickening of the tunica albuginea and focal plaques in 20% of their patients.…”

“…Basic and early clinical research suggested that it may be amendable to treatment with interferon [6, 7], a strategy we followed without success [8, 9]. Diagnosis rests upon clinical examination, autophotography and the use of one or several imaging techniques: high resolution ultrasound; X-ray in mammography technique; CT, and NMR, in rare cases cavernosography [10, 11, 12, 13, 14, 15]. We are the first to compare the four standard imaging techniques as part of ongoing treatment trials with a view to precise and reproducible plaque assessment.…”

Ultrasound and Soft-Tissue Radiography to Monitor Local Interferon-α2B Treatment in Peyronie's Disease

“…The role of ultrasound in determining plaque size remains a matter of debate: agreement between clinical and ultrasonographic findings in 90% of cases has been reported (1,6). However, in contradiction, recent research (10, 11) has found qualitative correlations of only 3945%.…”

Biomechanical aspects of Peyronie's disease in development stages and following reconstructive surgeries

“…This sensitivity is characteristically augmented in Peyronie's disease, because the dorsal part of the tunica is often the site of ossification. 1,2 Biomechanical consequences of Peyronie's disease Peyronie's disease has been characterized by ultrastructural changes in the tunica albuginea, and one resultant functional abnormality is the loss of elasticity. 16 This pathological tissue stiffening leads to significantly magnified and unevenly distributed stresses in the tunica albuginea of affected individuals.…”

“…As the disease progresses, parts of the dorsal=middle aspect of the tunica albuginea may ossify. 1,2 Painful erections during the acute stage (prominent in 30 -40% of the patients) and angulation of the erect penis toward the plaque during the chronic stage are common symptoms of the disease, which is also accompanied by erectile dysfunction in at least 20% of the cases. 3 During normal erection, mechanical stresses within the penis are adequately distributed to obviate intensive local pressure on nerve endings or within the vascular bed.…”