Biomechanical aspects of Peyronie's disease in development stages and following reconstructive surgeries

Gefen, Amit; Elad, David; Chen, J

doi:10.1038/sj.ijir.3900866

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…One example of poor agreement is shown in figure 8; the discrepancy here is unexplained although this patient had Peyronie's disease which is manifested by curvature of the penile shaft (Hakim et al 1996;Carriere et al 1998;Gefen et al 2002), and there may have been difficulty in determining the onset of buckling. Another example of cases showing poorer agreement between the measured and theoretical values of F BUC is shown in a Calculated for 17 of the 21 patients with cavernosal expandability determined by the value which gave the best least squares fit of the measured penile volume-intracavernosal pressure data in each patient and calculated for 4 of the 21 patients with cavernosal expandability determined by the best fit of the buckling force curve to the measured buckling force data.…”

Section: Obtaining Patient Datamentioning

confidence: 95%

“…The agreement of measured buckling forces with the theoretically predicted values in figure 7 was typical for approximately 80% of patients in the studies. One example of poor agreement is shown in figure 8; the discrepancy here is unexplained although this patient had Peyronie's disease which is manifested by curvature of the penile shaft (Hakim et al 1996;Carriere et al 1998;Gefen et al 2002), and there may have been difficulty in determining the onset of buckling. Another example of cases showing poorer agreement between the measured and theoretical values of F BUC is shown in figure 9 (Udelson et al 1998b).…”

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confidence: 89%

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Biomechanics of male erectile function

Udelson

2007

J. R. Soc. Interface.

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Two major branches of engineering mechanics are fluid mechanics and structural mechanics, with many practical problems involving the effect of the first on the second. An example is the design of an aircraft's wings to bend within reasonable limits without breaking under the action of lift forces exerted by the air flowing over them; another is the maintenance of the structural integrity of a dam designed to hold back a water reservoir which would exert very large forces on it. Similarly, fluid and structural mechanics are involved in the engineering analysis of erectile function: it is the hydraulic action of increased blood flow into the corpora cavernosa that creates the structural rigidity necessary to prevent collapse of the penile column.

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Section: Obtaining Patient Datamentioning

confidence: 95%

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confidence: 89%

Biomechanics of male erectile function

Udelson

2007

J. R. Soc. Interface.

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“…Bundles of the outer layer are longitudinally oriented, and extend from the glans penis to the proximal crura and insert into the inferior pubic ramus. Gefen et al 60 created a model that shows stress concentrated around blood vessels and nerve roots due to plaques forming in PD. This irritates nerve endings or compresses the vascular bed and eventually leads to penile deformities and/or painful erections.…”

Section: Introductionmentioning

confidence: 99%

New insights into the pathogenesis of Peyronie's disease: A narrative review

Krakhotkin¹,

Chernylovskyi²,

Mottrie

et al. 2020

Chronic Diseases and Translational Medicine

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Peyronie’s disease (PD) is a benign, progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea (TA) of the penis. This study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines, cell signaling pathways, biochemical mechanisms, genetic factors responsible for fibrogenesis. A growing body of literature has shown that PD is a chronically impaired, localized, wound healing process within the TA and the Smith space. It is caused by the influence of different pathological stimuli, most often the effects of mechanical stress during sexual intercourse in genetically sensitive individuals with unusual anatomical TA features, imbalanced matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP), and suppressed antioxidant systems during chronic inflammation. Other intracellular signal cascades are activated during fibrosis along with low expression levels of their negative regulators and transforming growth factor-β1 signaling. The development of multikinase agents with minimal side effects that can block several signal cell pathways would significantly improve fibrosis in PD tissues by acting on common downstream mediators.

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“…These stresses may irritate nerve endings or compress the vascular bed and thus cause penile deformity and/or painful erection. The model was further used to elaborate the effects of different biological or artificial materials for reconstruction of the penis following plaque removal [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Superficial Tunica Albuginea Rupture as Initial Starting Point of Peyronie’s Disease: A Topic for Interdisciplinary Consideration

Herwig¹,

Bayerl²

2015

BioMed Research International

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Peyronie's disease is a connective tissue disorder in the soft tissue of the penis. The underlying cause of Peyronie's disease is not well understood but is thought to be caused by trauma or injury to the penis during sexual intercourse. The purpose of the interdisciplinary cooperation between urological surgery and physics is the development of a physical simulation tool in order to give prognosis of possible tunica albuginea fibre rupture at a certain degree of deviation of the penis. For our group the first challenge was to translate the human organ of the penis into a physical model. Starting and marginal parameters had to be defined, whereby some of them had to be based on assumption, as physical data of the human living tissue have rarely been measured up to now. The algorithm and its dependencies had to be developed. This paper is a first step of a three-dimensional mathematical-physical simulation with the assumption of a 100% filled rigid penis. The calculation gives proof of the hypothesis that the fibre-load-angle of the penis is less than 12 degrees. Thus physical simulation is able to provide the surgeon with a simple instrument to calculate and forecast the risk of the individual patient.

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Biomechanical aspects of Peyronie's disease in development stages and following reconstructive surgeries

Cited by 7 publications

References 25 publications

Biomechanics of male erectile function

Biomechanics of male erectile function

New insights into the pathogenesis of Peyronie's disease: A narrative review

Superficial Tunica Albuginea Rupture as Initial Starting Point of Peyronie’s Disease: A Topic for Interdisciplinary Consideration

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