Ultrasound-guided Platelet-rich Plasma Application Versus Corticosteroid Injections for the Treatment of Greater Trochanteric Pain Syndrome: A Prospective Controlled Randomized Comparative Clinical Study

Begkas, Dimitrios; Chatzopoulos, Stamatios-Theodoros; Touzopoulos, Panagiotis; Balanika, Alexia; Pastroudis, Alexandros

doi:10.7759/cureus.6583

Cited by 10 publications

(18 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, the efficacy of PRP injection vs corticosteroid injection in the treatment of a variety of musculoskeletal disorders including plantar fasciitis, [ 34 ] elbow epicondylitis, [ 35 ] knee osteoarthritis, [ 36 ] greater trochanteric pain syndrome, [ 37 ] and rotator cuff lesions [ 38 ] has been compared. Nevertheless, the efficacy of PRP injection vs corticosteroid injection as a conservative treatment for rotator cuff lesions remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma injection vs corticosteroid injection for conservative treatment of rotator cuff lesions

Wang¹,

Zhang²,

Ma³

et al. 2021

Medicine

View full text Add to dashboard Cite

Background: To explore the effectiveness of platelet-rich plasma (PRP) injection regarding functional recovery, pain relief, and range of motion (ROM) of shoulder compared with the corticosteroid injection in patients with rotator cuff lesions treated non-operatively. Methods: An electronic literature search was performed by 2 authors in the PubMed, Embase, Cochrane Library, and Web of Science databases to identify relevant randomized controlled trial (RCTs) that were published up to July 20, 2020. The quality of the included RCTs was evaluated using the approach recommended by the Cochrane Handbook for Systematic Reviews of Interventions. Standardized mean differences (SMDs) or mean differences (MDs) with 95% confidence intervals (CIs) were applied to calculate the pooled effect sizes. Results: Six RCTs were included in this systematic review. Meta-analysis revealed that corticosteroid injection yielded statistically significant superior functional recovery (SMD = −0.80; 95% CI, −1.42 to −0.18; P = .01) and pain relief (MD = 1.59; 95% CI, 0.30–2.89; P = .02) compared with PRP injection for rotator cuff lesions during the short-term follow-up period. However, at the medium-term and long-term follow-up, no statistically significant difference was identified between the 2 groups. Regarding the ROM of shoulder, no statistically significant difference was found between the 2 groups during the whole follow-up period. Conclusions: The current clinical evidence revealed short-term efficacy of corticosteroid injection and no significant medium- to long-term difference between corticosteroid and PRP injection in the treatment of rotator cuff lesions. Additional studies with longer follow-ups, larger sample sizes, and more rigorous designs are needed to draw more reliable and accurate conclusions.

show abstract

Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma injection vs corticosteroid injection for conservative treatment of rotator cuff lesions

Wang¹,

Zhang²,

Ma³

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

“…A recent randomized clinical trial of 24 patients with GTPS compared PRP injections with CSI over a 2-year follow-up period. 53 At 1 month, the CSI group showed significantly greater improvement in pain and function than the PRP group, with HHS improvements of 33 and 25 points, respectively ( p < 0.05), and VAS score improvements of 4.6 and 2.6 points, respectively ( p < 0.05), compared with the pre-injection baseline scores. However, at 2-year follow-up, patients who received a CSI returned to their pre-injection HHS and VAS scores, whereas the PRP group experienced sustained improvements of 40 and 5.7 points, respectively ( p < 0.05 for both).…”

Section: Nonoperative Managementmentioning

confidence: 82%

Greater trochanteric pain syndrome: Evaluation and management of a wide spectrum of pathology

et al. 2021

View full text Add to dashboard Cite

Greater trochanteric pain syndrome is a common cause of lateral hip pain, encompassing a spectrum of disorders, including trochanteric bursitis, abductor tendon pathology, and external coxa saltans. Greater trochanteric pain syndrome is primarily a clinical diagnosis, and careful clinical examination is essential for accurate diagnosis and treatment. A thorough history and physical exam may be used to help differentiate greater trochanteric pain syndrome from other common causes of hip pain, including osteoarthritis, femoroacetabular impingement, and lumbar stenosis. Although not required for diagnosis, plain radiographs and magnetic resonance imaging may be useful to exclude alternative pathologies or guide treatment of greater trochanteric pain syndrome. The majority of patients with greater trochanteric pain syndrome respond well to conservative management, including physical therapy, non-steroidal anti-inflammatory drugs, and corticosteroid injections. Operative management is typically indicated in patients with chronic symptoms refractory to conservative therapy. A wide range of surgical options, both open and endoscopic, are available and should be guided by the specific etiology of pain. The purpose of this review is to highlight pertinent clinical and radiographic features used in the diagnosis and management of greater trochanteric pain syndrome. In addition, treatment indications, techniques, and outcomes are described.

show abstract

“…Due to case report [ 22 ], duplicate [ 23 ], no required data [ 24 – 27 ], and study design [ 28 – 30 ], 9 studies were excluded. Finally, 8 RCTs [ 31 – 38 ]were included in our meta-analysis, which included a total of 764 participants. The study flowchart is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

The effect of corticosteroid injection in the treatment of greater trochanter pain syndrome: a systematic review and meta-analysis of randomized controlled trials

Wang

Qin

et al. 2022

J Orthop Surg Res

View full text Add to dashboard Cite

Background corticosteroid injection (CSI) has been used to treat greater trochanter pain syndrome (GTPS) for many years. However, so far, the efficacy of CSI in the treatment of GTPS is still controversial. Therefore, the aim of this review is to evaluate the effectiveness of CSI in comparison with sham intervention, nature history, usual care, platelet-rich plasma (PRP), physiotherapy/exercise therapy, dry needling, or other nonsurgical treatment for improvements in pain and function in GTPS. Methods PubMed (Medline), Embase, Cochrane Library were searched from their inception until April 2021. Randomized controlled trails (RCTs) comparing CSI to nonsurgical treatment were included. Data on the effect of CSI on pain and function were extracted and checked by two review authors independently. The treatment effect was analyzed in the short term, medium term, and long term. Results Eight RCTs (764 patients) were included. This review suggests CSI may be superior to usual care and ‘wait and see,’ ESWT, but may not be superior to exercise, PRP, dry needling, and sham intervention in short-term pain or function improvement. In terms of medium-term pain or function improvement, CSI may be superior to usual care and ‘wait and see,’ but may not be superior to PRP. In terms of long-term pain or function improvement, CSI may be inferior to PRP and ESWT, but it may be superior to usual care and ‘wait and see’ at 12 months. Conclusions Due to the small sample size and lack of sufficient clinical studies, current evidence is equivocal regarding the efficacy of CSI in the treatment of GTPS. Considering the limitations, more large-sample and high-quality RCTs are needed to prove the therapeutic effect of CSI on GTPS. Trial registration PROSPERO registration number: CRD42021247991. Registered 09 May 2021.

show abstract

Ultrasound-guided Platelet-rich Plasma Application Versus Corticosteroid Injections for the Treatment of Greater Trochanteric Pain Syndrome: A Prospective Controlled Randomized Comparative Clinical Study

Cited by 10 publications

References 27 publications

Platelet-rich plasma injection vs corticosteroid injection for conservative treatment of rotator cuff lesions

Platelet-rich plasma injection vs corticosteroid injection for conservative treatment of rotator cuff lesions

Greater trochanteric pain syndrome: Evaluation and management of a wide spectrum of pathology

The effect of corticosteroid injection in the treatment of greater trochanter pain syndrome: a systematic review and meta-analysis of randomized controlled trials

Contact Info

Product

Resources

About