Ultrasound‐guided photodynamic therapy for deep seated pathologies: prospective study

Jerjes, Waseem; Upile, Tahwinder; Hamdoon, Zaid; Nhembe, Farai; Bhandari, Rishi; Mackay, Sorcha; Shah, Priya; Mosse, Charles A.; Brookes, Jocelyn; Morley, Simon; Hopper, Colin

doi:10.1002/lsm.20853

Cited by 54 publications

(67 citation statements)

References 10 publications

(27 reference statements)

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“…4 In clinical trials of interstitial PDT, the outcome of the treatment has often been variable. 5 This may be due to limited control of local photosensitizer concentration, 6 the local light dose distribution in the tissue, 7 and unknown tissue oxygen concentration, 8 all of which may lead to variability in the generated dose of singlet oxygen. A key issue in the development of interstitial PDT for prostate cancer is to control the singlet oxygen dose and its distribution in the tissues, to ensure destruction of the malignant tissue while at the same time minimizing damage to surrounding organs.…”

Section: Introductionmentioning

confidence: 99%

Online dosimetry for temoporfin-mediated interstitial photodynamic therapy using the canine prostate as model

et al. 2016

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Online dosimetry for temoporfin-mediated interstitial photodynamic therapy using the canine prostate as model. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Online dosimetry for temoporfinmediated interstitial photodynamic therapy using the canine prostate as model Abstract. Online light dosimetry with real-time feedback was applied for temoporfin-mediated interstitial photodynamic therapy (PDT) of dog prostate. The aim was to investigate the performance of online dosimetry by studying the correlation between light dose plans and the tissue response, i.e., extent of induced tissue necrosis and damage to surrounding organs at risk. Light-dose planning software provided dose plans, including light source positions and light doses, based on ultrasound images. A laser instrument provided therapeutic light and dosimetric measurements. The procedure was designed to closely emulate the procedure for wholeprostate PDT in humans with prostate cancer. Nine healthy dogs were subjected to the procedure according to a light-dose escalation plan. About 0.15 mg∕kg temoporfin was administered 72 h before the procedure. The results of the procedure were assessed by magnetic resonance imaging, and gross pathology and histopathology of excised tissue. Light dose planning and online dosimetry clearly resulted in more focused effect and less damage to surrounding tissue than interstitial PDT without dosimetry. IntroductionProstate cancer is one of the most common cancer forms in men.1 Current radical treatments, which include surgery and radiotherapy, are associated with side effects primarily in the form of impotence and incontinence. Interstitial photodynamic therapy (PDT) is one alternative technique to treat prostate cancer. 3 The method relies on the use of a light activated drug, photosensitizer, and provides a minimally invasive treatment by the use of needles to insert optical fibers that guide the light to the target tissue. In addition, interstitial PDT potentially offers several other advantages: few side effects, rapid recovery, repeatable treatment if needed, and the method does not exclude other treatment options. Interstitial light delivery, in contrast to traditional PDT which utilizes surface illumination, allows treatment of voluminous tumors with complex structure inside the body...

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Section: Introductionmentioning

confidence: 99%

Online dosimetry for temoporfin-mediated interstitial photodynamic therapy using the canine prostate as model

et al. 2016

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“…Photodynamic therapy (PDT) has been applied in the management of superficial and deep pathologies involving the head and neck [5-11]. PDT has been successful in managing superficial diseases such as oral premalignant disorders and early (T1/T2) oral cancer [12-14].…”

Section: Introductionmentioning

confidence: 99%

“…PDT has been successful in managing superficial diseases such as oral premalignant disorders and early (T1/T2) oral cancer [12-14]. Successful applications were also reported in the management of nasopharyngeal carcinoma [15,16], tongue base carcinoma [17-19], subglottic carcinoma [20], vascular anomalies [5,10,21-23], sarcomas [5,10,24], pericarotid disease [25], metastatic disease to the orofacial region [26], mantle lymphoma [27] and Kimura disease [28]. The advancement in photodynamic applications suggests that PDT may be more effective when combined with other modalities, (i.e.…”

Section: Introductionmentioning

confidence: 99%

Solitary giant neurofibroma of the neck subjected to photodynamic therapy: case study

2012

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Photodynamic therapy (PDT) - the fourth modality - has been successfully used in the management of early and advanced pathologies of the head and neck. We studied the effect of this modality on a giant solitary neurofibroma of the neck. A 70-year-old Caucasian female presented with left neck pain and disfigurement associated with slight shortness of breath and dysphagia. Examination revealed a large mass in the neck with no neurovascular compromise. Magnetic resonance imaging (MRI) reported a heterogeneously enhancing mass extending from the left angle of the mandible to the base of the neck. A core biopsy was performed and histopathological examination revealed a disorganised array of peripheral nerve fascicles. The patient elected to receive photodynamic therapy as the primary intervention. The multi-disciplinary meeting approved the treatment plan. The photosensitizing agent was mTHPC (0.15 mg/kg), which was systemically administered 96-hours prior to ultrasound (US)-guided light delivery to the mass, which was undertaken under general anaesthesia. Recovery was uneventful.Post-PDT follow-up showed that the patient’s pain, dysphagia and shortness of breath issues had improved. The disfigurement of the neck caused by the mass was no longer a problem. Three months post-PDT, MRI revealed a significant reduction in the neurofibroma size. PDT was proven as a successful primary intervention for this pathology. However, higher evidence-based studies are required before this therapy can be proposed as a replacement to any of the other conventional therapies.

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“…surgery, radiotherapy or chemotherapy). The treatment can be repeated as often as necessary since it has no cumulative toxicity [12-14]. …”

Section: Introductionmentioning

confidence: 99%

“…necrosis and peri-lesional inflammation), [12-14]. A potent second-generation photosensitiser, Foscan (temoporfin; meta-tetrahydroxyphenyl chlorine) has been approved for treatment of advanced head and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy in the management of potentially malignant and malignant oral disorders

Jerjes

Hopper

2012

Head Neck Oncol

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Photodynamic therapy (PDT) is a minimally-invasive surgical tool successfully targeting premalignant and malignant disorders in the head and neck, gastrointestinal tract, lungs and skin with greatly reduced morbidity and disfigurement. The technique is simple, can commonly be carried out in outpatient clinics, and is highly acceptable to patients. The role of photodynamic therapy in the management of oral potentially malignant disorders and early oral cancer is being discussed.

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Ultrasound‐guided photodynamic therapy for deep seated pathologies: prospective study

Abstract: This study on 68 patients with deep-seated pathologies undergoing interstitial photodynamic therapy provided evidence that PDT can be the fourth modality in the management of tissue disease.

Cited by 54 publications

References 10 publications

Online dosimetry for temoporfin-mediated interstitial photodynamic therapy using the canine prostate as model

Online dosimetry for temoporfin-mediated interstitial photodynamic therapy using the canine prostate as model

Solitary giant neurofibroma of the neck subjected to photodynamic therapy: case study

Photodynamic therapy in the management of potentially malignant and malignant oral disorders

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