Photodynamic therapy in the management of potentially malignant and malignant oral disorders

Jerjes, Waseem; Hopper, Colin

doi:10.1186/1758-3284-4-16

Cited by 33 publications

(16 citation statements)

References 37 publications

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“…In previous studies, McGillis and Fein 15 and Rivard and Ozog 16 have also applied ALA for 30 minutes before illumination and exposition to light for 10 minutes in 3 fractions. In most of the previous studies the light sources used were lasers at 635 nm, Kübler et al, 17 Fan et al, 18 Kubler et al, 19 Sieron et al, 20 Sieroń et al, 21 Tsai et al, 22 Chen et al, 23 Lin et al, 24 and 585 nm, Franco, 25 Shafirstein et al 26 But, because of their bulkiness and high cost, we have chosen LED at 420 nm, like McGillis and Fein, 15 Rivard and Ozog, 16 Ericson et al, 27 Jerjes et al, 28 as it is cheaper, convenient, safe and easy to use in the treatment of OL and OLP. In the present study, 12 OL lesions were treated with 5-ALA mediated PDT, among which 2 (16.7%) showed complete response, 8 (66.67%) partial response and 2 (16.7%) no response.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

et al. 2016

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Introduction: Oral premalignant lesions are conditions having high potential tendency for transformation into malignancy. The use of a conservative and effective treatment modality is one of the best strategies for cancer prevention. Photodynamic therapy (PDT) is a noninvasive method for topical and selective treatment of oral precancerous lesions. The present study was taken up to determine the efficacy of PDT in oral precancerous lesions. Methods: The study consisted 13 patients with 24 oral leukoplakia (OL) lesions and 8 with 20 oral lichen planus (OLP) lesions, divided into control and study groups. These lesions were affecting various intraoral sites, the buccal mucosa being the most common site followed by tongue and gingiva. The treatment regimen of PDT included 98% 5-aminolevulinic acid (5-ALA) which is topical applied and irradiated with light emitting diode (LED) of 420 nm wavelengths at several sessions. Results: In OL 16.6% of cases showed complete response, 66.6% partial response and 16.6% no response of the lesions to the treatment. In OLP 80% and 20% of the lesions showed partial and no response respectively. The differences with control groups for OL + OLP were found to be significant (P < 0.001). Conclusion: Based on the results of the present study, we can conclude that PDT appears to be a feasible alternative to conventional therapy for oral premalignant lesions.

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Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

et al. 2016

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“…[19–22] PDT, using a photosensitizer and laser emission, has been applied quite successfully in Japan for the last 15 years against the early cancers of esophagus, lung, stomach and cervix of the uterus. For the head and neck cancer also it has shown a good promise [23–26].…”

Section: Introductionmentioning

confidence: 99%

Combination of Sonodynamic and Photodynamic Therapy against Cancer Would Be Effective through Using a Regulated Size of Nanoparticles

Miyoshi¹,

Kundu²,

Tuziuti³

et al. 2016

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Nanoparticles have been used for many functional materials in nano-sciences and photo-catalyzing surface chemistry. The titanium oxide nanoparticles will be useful for the treatment of tumor by laser and/or ultrasound as the sensitizers in nano-medicine. We have studied the combination therapy of photo- and sono-dynamic therapies in an animal tumor model. Oral-administration of two sensitizers titanium oxide, 0.2%-TiO2 nanoparticles for sono-dynamic and 1 mM 5-aminolevulinic acid for photodynamic therapies have resulted in the best combination therapeutic effects for the cancer treatment. Our light microscopic and Raman spectroscopic studies revealed that the titanium nanoparticles were distributed inside the blood vessel of the cancer tissue (1–3 μm sizes). Among these nanoparticles with a broad size distribution, only particular-sized particles could penetrate through the blood vessel of the cancer tissue, while other particles may only exhibit the side effects in the model mouse. Therefore, it may be necessary to separate the optimum size particles. For this purpose we have separated TiO2 nanoparticles by countercurrent chromatography with a flat coiled column (1.6 mm ID) immersed in an ultrasonic bath (42 KHz). Separation was performed with a two-phase solvent system composed of 1-butanol-acetic acid-water at a volume ratio of 4:1:5 at a flow rate of 0.1 ml/min. Countercurrent chromatographic separation yielded fractions containing particle aggregates at 31 and 4400 nm in diameter.

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“…PDT has been successful in managing superficial diseases such as oral premalignant disorders and early (T1/T2) oral cancer [12-14]. Successful applications were also reported in the management of nasopharyngeal carcinoma [15,16], tongue base carcinoma [17-19], subglottic carcinoma [20], vascular anomalies [5,10,21-23], sarcomas [5,10,24], pericarotid disease [25], metastatic disease to the orofacial region [26], mantle lymphoma [27] and Kimura disease [28].…”

Section: Introductionmentioning

confidence: 99%

Solitary giant neurofibroma of the neck subjected to photodynamic therapy: case study

2012

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Photodynamic therapy (PDT) - the fourth modality - has been successfully used in the management of early and advanced pathologies of the head and neck. We studied the effect of this modality on a giant solitary neurofibroma of the neck. A 70-year-old Caucasian female presented with left neck pain and disfigurement associated with slight shortness of breath and dysphagia. Examination revealed a large mass in the neck with no neurovascular compromise. Magnetic resonance imaging (MRI) reported a heterogeneously enhancing mass extending from the left angle of the mandible to the base of the neck. A core biopsy was performed and histopathological examination revealed a disorganised array of peripheral nerve fascicles. The patient elected to receive photodynamic therapy as the primary intervention. The multi-disciplinary meeting approved the treatment plan. The photosensitizing agent was mTHPC (0.15 mg/kg), which was systemically administered 96-hours prior to ultrasound (US)-guided light delivery to the mass, which was undertaken under general anaesthesia. Recovery was uneventful.Post-PDT follow-up showed that the patient’s pain, dysphagia and shortness of breath issues had improved. The disfigurement of the neck caused by the mass was no longer a problem. Three months post-PDT, MRI revealed a significant reduction in the neurofibroma size. PDT was proven as a successful primary intervention for this pathology. However, higher evidence-based studies are required before this therapy can be proposed as a replacement to any of the other conventional therapies.

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Photodynamic therapy in the management of potentially malignant and malignant oral disorders

Cited by 33 publications

References 37 publications

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

Photodynamic Therapy – A Non-invasive Treatment Modality for Precancerous Lesions

Combination of Sonodynamic and Photodynamic Therapy against Cancer Would Be Effective through Using a Regulated Size of Nanoparticles

Solitary giant neurofibroma of the neck subjected to photodynamic therapy: case study

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