Ultrasound-Guided Percutaneous Microwave Ablation Treatment of Initial Recurrent Hepatocellular Carcinoma after Hepatic Resection: Long-Term Outcomes

Zhang, Tingting; Luo, Hongchang; Cui, Xian Wei; Zhang, Wei; Zhang, Liying; Chen, Xiaoping; Li, Kaiyan

doi:10.1016/j.ultrasmedbio.2015.04.019

Cited by 12 publications

(12 citation statements)

References 29 publications

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“…Air pollution is a significant epidemiological hazard that is associated with OM development. A few studies have revealed a consistent association between air pollution and hospital visits in patients with OM (Uhari et al 1995;Zhang et al 2015). b HMEECs were stained with JC-1, which formed red fluorescent aggregates.…”

Section: Discussionmentioning

confidence: 99%

Effects of reactive oxygen species generation induced by Wonju City particulate matter on mitochondrial dysfunction in human middle ear cell

Lee

Jeong

et al. 2021

Environ Sci Pollut Res

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Atmospheric particulate matter (PM) contains different components that can elicit varying adverse health effects in humans and animals. Studies on PM toxicity and its underlying mechanisms in the middle ear are limited, and they generally use a PM standard. However, as PM composition varies temporally and geographically, it is crucial to identify the toxic PM constituents according to season and region and investigate their associated health effects. Thus, we sought to determine whether PM induces cytotoxicity and inflammatory factor and reactive oxygen species (ROS) generation in human middle ear epithelial cells obtained from patients with otitis media. The cells were treated with both standard urban PM and PM directly captured from the atmosphere in Wonju City. The association between mitochondrial dysfunction and PM was investigated. PM exposure significantly increased COX-2 and TNF-α mRNA expression, increased ROS generation, induced inflammatory responses, and caused abnormalities in mitochondrial motility and function. Furthermore, PM induced cell apoptosis, which consequently reduced cell survival, particularly at the concentration of 100 μg/mL. Overall, our study provides new insights into the toxic effects of standard and atmospheric PM on middle ear cell line.

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Section: Discussionmentioning

confidence: 99%

Effects of reactive oxygen species generation induced by Wonju City particulate matter on mitochondrial dysfunction in human middle ear cell

Lee

Jeong

et al. 2021

Environ Sci Pollut Res

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“…The 1-, 3-, and 5-year OS rates were 94%, 69%, and 46%, respectively, for the TACE/RFA group and 82%, 47%, and 36% for the RFA group. As mentioned, we only found one study which evaluated the percutaneous performance of MWA for recurrent HCC after surgical resection by Zhang et al [ 17 ]. The 1- and 3-year OS rates were 86.2% and 73.3, respectively, for the MWA group and 96.2%, and 76.9%, respectively, for the re-resection group.…”

Section: Discussionmentioning

confidence: 99%

“…As we know, there was only one study in the literature by Zhang et al [ 17 ], which investigated the efficacy of percutaneous MWA and compared it with repeat hepatectomy for recurrent HCC after curative surgical resection on a long-term basis.…”

Section: Introductionmentioning

confidence: 99%

Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection

Adwan

Hammann

Vogl

2023

JCM

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Purpose: To evaluate the efficacy and safety of microwave ablation (MWA) as a treatment for recurrent hepatocellular carcinoma (HCC) after initial successful surgical resection. Methods: This retrospective study included 40 patients (11 women and 29 men; mean age: 62.3 ± 11.7 years) with 48 recurrent lesions of HCC after initial surgical resection that were treated by percutaneous MWA. Several parameters including complications, technical success, local tumor progression (LTP), intrahepatic distant recurrence (IDR), overall survival (OS), and progression-free survival (PFS) were evaluated in order to investigate the safety and efficacy of MWA for these recurrent HCC lesions after surgical treatment. Results: All MWA treatments were performed without complications or procedure-related deaths. Technical success was achieved in all cases. Two cases developed LTP at a rate of 5%, and IDR occurred in 23 cases at a rate of 57.5% (23/40). The 1-, 2-, 3-, 4-, and 6-year OS rates were 97%, 89.2%, 80.3%, 70.2%, and 60.2%, respectively. The 1- and 3-year PFS rates were 50.2% and 34.6%, respectively. Conclusion: MWA is effective and safe as a local treatment for recurrent HCC after initial surgical resection.

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“…Ultrasound guidance technology has the advantages of real-time monitoring, accurate guidance, negligible trauma, safety and effectiveness, easy operation and repeatability ( 6 ). These advantages have led this technology to be considered as one of the three major types of treatment for liver cancer together with surgery and regional vascular intervention ( 7 ). Ultrasound guidance technology aims to effectively treat tumors or cytoreduction, reducing symptoms, improving life quality and extending survival time.…”

Section: Discussionmentioning

confidence: 99%

Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis

Sun

Zhang

et al. 2016

Oncology Letters

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Liver cancer is a malignancy of the digestive system and has a high morbidity and mortality rate. Local intervention has become a viable option in identifying liver treatment. The aim of the present study was to analyze the clinical effects of treating liver cancer in middle and advanced stages using ultrasound-guided percutaneous ethanol injection (PEI) in tumors combined with radiofrequency ablation (RFA). A total of 100 patients with stage III–IV liver cancers were selected to participate in the study. Patients were divided into groups. In group A, treatment was initiated with PEI and after 1–2 weeks RFA was applied while in group B treatment was initiated with RFA and after 1–2 weeks PEI was applied. Patients in group C received PEI and RFA simultaneously. The clinical effects in the 3 groups were compared after 6-month follow ups. The volume of tumor ablation necrosis in group A was significantly greater than that in the groups B and C, while the size was significantly smaller compared to groups B and C after ablation. For group A, the complete ablation rate was significantly higher than that in groups B and C, and the differences were statistically significant (P<0.05). Liver damage indices, including raising levels of glutamic-pyruvic transaminase and total bilirubin, were significantly decreased in group A (P<0.05). The survival rate in group A was also significantly higher than in groups B and C (P<0.05). In conclusion, for patients with liver cancer in middle and advanced stages, the treatment method using PEI followed by RFA was more beneficial in terms of improving the tumor ablation rate, alleviating liver damages and increasing survival rates.

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Ultrasound-Guided Percutaneous Microwave Ablation Treatment of Initial Recurrent Hepatocellular Carcinoma after Hepatic Resection: Long-Term Outcomes

Cited by 12 publications

References 29 publications

Effects of reactive oxygen species generation induced by Wonju City particulate matter on mitochondrial dysfunction in human middle ear cell

Effects of reactive oxygen species generation induced by Wonju City particulate matter on mitochondrial dysfunction in human middle ear cell

Microwave Ablation of Recurrent Hepatocellular Carcinoma after Curative Surgical Resection

Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis

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