Ultrasound Guided Ablative-Laser Assisted Photodynamic Therapy of Basal Cell Carcinoma (US-aL-PDT)

Abstract

With proper ultrasound case selection and laser ablation before MAL-PDT, the depth of a BCC lesion is not a limiting factor for PDT, and aesthetic outcomes are very good. Therefore, ultrasound-guided ablative laser-assisted PDT of BCC can be the method of choice, particularly in aesthetically challenging cases.

Confocal Imaging–Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study

“…Laser ablation is a promising approach for minimally invasive removal of superficial and early nodular basal cell carcinomas (BCCs) (Smucler et al , 2008, 2012). Skin can be removed in μm-thin layers in a well-controlled manner, increasing preservation of the surrounding normal tissue.…”

Clinical use of photodynamic therapy in ocular tumors

“…25, 180 Noncoherent light sources and conventional arc lamps are often preferred because they are less expensive, produce a wide spectrum of light, and may be used with various photosensitizers. In conjunction with filters, they may also be used for output-selective wavelengths.…”

Laser‐assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's disease: a randomized intrapatient comparison between a continuous and a fractional ablative CO2 laser mode

“…Several preclinical studies showed facilitated accumulation of topically applied drugs . Clinical studies demonstrated enhanced lesion response when CO 2 or erbium‐doped yttrium aluminium garnet (Er:YAG) laser preceded PDT compared to PDT or laser alone . Ablative laser‐assisted PDT is considered to offer good tolerability, satisfactory aesthetics and might provide other advantages such as reduced photosensitizer incubation time …”

“…[13][14][15][16] Clinical studies demonstrated enhanced lesion response when CO 2 or erbium-doped yttrium aluminium garnet (Er:YAG) laser preceded PDT compared to PDT or laser alone. 2,[17][18][19][20][21][22][23][24][25] Ablative laser-assisted PDT is considered to offer good tolerability, satisfactory aesthetics and might provide other advantages such as reduced photosensitizer incubation time. 18,25,26 Both continuous ablative and fractional ablative laser devices have been explored.…”