Ultrasound evaluation of subcutaneous and visceral abdominal fat as a predictor of gestational diabetes mellitus: a systematic review

Benevides, Fernanda Teixeira; Júnior, Edward Araujo; Maia, Carla Soraya Costa; Júnior, Renan Magalhães Montenegro; Carvalho, Francisco Herlânio Costa

doi:10.1080/14767058.2020.1781808

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…In the case of central and visceral body fats, Benevides et al(2020) reported that the cut-off point for subcutaneous, visceral, and total abdominal fat to predict GDM varied between studies in the first and second trimesters of pregnancy. No study confirmed a model for predicting GDM using subcutaneous and visceral fat measurements [ 78 ].…”

Section: Discussionmentioning

confidence: 99%

Association of body composition in early pregnancy with gestational diabetes mellitus: A meta-analysis

et al. 2022

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Introduction Body composition as dynamic indices constantly changes in pregnancy. The use of body composition indices in the early stages of pregnancy has recently been considered. Therefore, the current meta-analysis study was conducted to investigate the relationship between body composition in the early stages of pregnancy and gestational diabetes. Method Valid databases searched for papers published from 2010 to December 2021 were based on PRISMA guideline. Newcastle Ottawa was used to assess the quality of the studies. For all analyses, STATA 14.0 was used. Mean difference (MD) of anthropometric indices was calculated between the GDM and Non-GDM groups. Pooled MD was estimated by “Metan” command, and heterogeneity was defined using Cochran’s Q test of heterogeneity, and I 2 index was used to quantify heterogeneity. Results Finally, 29 studies with a sample size of 56438 met the criteria for entering the meta-analysis. Pooled MD of neck circumference, hip circumference, waist hip ratio, and visceral adipose tissue depth were, respectively, 1.00 cm (95% CI: 0.79 to 1.20) [N = 5; I^2: 0%; p: 0.709], 7.79 cm (95% CI: 2.27 to 13.31) [N = 5; I2: 84.3%; P<0.001], 0.03 (95% CI: 0.02 to 0.04) [N = 9; I2: 89.2%; P<0.001], and 7.74 cm (95% CI: 0.11 to 1.36) [N = 4; I^2: 95.8%; P<0.001]. Conclusion Increased neck circumference, waist circumference, hip circumference, arm circumference, waist to hip ratio, visceral fat depth, subcutaneous fat depth, and short stature increased the possibility of developing gestational diabetes. These indices can accurately, cost-effectively, and affordably assess the occurrence of gestational diabetes, thus preventing many consequences with early detection of gestational diabetes.

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Section: Discussionmentioning

confidence: 99%

Association of body composition in early pregnancy with gestational diabetes mellitus: A meta-analysis

et al. 2022

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“…Two other studies show that VAT area (as extracted from a single scan obtained at the level of umbilicus, ie, approximately the level of L4-L5) was highly correlated with total VAT volume. 18 , 19 …”

Section: Methodsmentioning

confidence: 99%

“…Within the context of EC, VAT has been associated with several of its risk factors, including hypertension, 18 diabetes mellitus, 19 and polycystic ovarian syndrome. 20 A prospective epidemiologic risk factor study found that central obesity was associated with increased risk of female genital organ cancers in postmenopausal women, independent of their BMI.…”

Section: Introductionmentioning

confidence: 99%

“…Mounting evidence suggests that the distribution of abdominal adipose tissue may be related to the effect of therapeutic interventions on and prognosis of several types of cancers, including malignant melanomas, 15 colorectal, 16 and esophageal cancers. 17 Within the context of EC, VAT has been associated with several of its risk factors, including hypertension, 18 diabetes mellitus, 19 and polycystic ovarian syndrome. 20 A prospective epidemiologic risk factor study found that central obesity was associated with increased risk of female genital organ cancers in postmenopausal women, independent of their BMI.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Abdominal Adipose Tissue Distribution and Risk of Endometrial Cancer: A Case-Control Study

Cheng

Wang

Jia

et al. 2022

Clin Med Insights Oncol

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Background: Obesity contributes to endometrial cancer (EC). However, it is not clear whether the distribution of adipose tissue affects the occurrence of endometrial carcinoma. This study aimed to evaluate the relationship between abdominal adipose tissue distribution and EC. Methods: We designed a case-control study with 115 women with EC and a control group. The total abdominal adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue were measured by single slice computerized tomography at the level of umbilicus. Univariate and multivariate logistic regression models were used to calculate odds ratios (ORs) for the risk of EC associated with adipose tissue distribution. Furthermore, we analyzed the correlation between adipose tissue distribution and clinicopathologic features of endometrial carcinoma. Results: Multivariate analysis showed that a larger visceral adipose tissue ratio was associated with an increased risk of EC after adjusting for body mass index (BMI) and diabetes (OR = 1.046, 95% confidence interval = [1.008-1.079]). The ratio of International Federation of Obstetrics and Gynecology (FIGO) stage I and type I EC was higher in EC patients with larger visceral adipose tissue (84.5% vs 63.2%, P = .009; 91.4% vs 75.4%, P = .021). There was a higher positive ratio of progesterone receptor in EC patients with a larger subcutaneous adipose tissue area (91.2% vs 77.6%; P = .044). Conclusions: Higher visceral adipose tissue ratio, independent of BMI, was associated with an increased risk of EC. Therefore, this study demonstrated that women with normal BMI, but abnormal abdominal adipose tissue distribution, have an increased risk for EC.

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“…As the disease progresses, chronic inflammation is maintained and manifests as an increased myeloid cell number and a decreased lymphoid cell number, a process called skewed myelopoiesis. Skewed myelopoiesis has been demonstrated in streptozotocin-induced type 1 diabetic mice 2,3 , obese db/db mice 4 , and T2DM patients 5 . The inflammatory cells, together with proinflammatory cytokines, chemokines, and enzymes, reinforce the progression of diabetes and the resulting vascular complications.…”

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confidence: 99%

The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression

et al. 2022

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Hyperglycemia-induced myelopoiesis and atherosclerotic progression occur in mice with type I diabetes. However, less is known about the effects of metabolites on myelopoesis in type 2 diabetes. Here, we use fluorescence-activated cell sorting to analyze the proliferation of granulocyte/monocyte progenitors (GMP) in db/db mice. Using targeted metabolomics, we identify an increase in inosine monophosphate (IMP) in GMP cells of 24-week-old mice. We show that IMP treatment stimulates cKit expression, ribosomal S6 activation, GMP proliferation, and Gr-1+ granulocyte production in vitro. IMP activates pAkt in non-GMP cells. In vivo, using an established murine acute pancreatitis (AP) model, administration of IMP-treated bone marrow cells enhances the severity of AP. This effect is abolished in the presence of a pAkt inhibitor. Targeted metabolomics show that plasma levels of guanosine monophosphate are significantly higher in diabetic patients with AP. These findings provid a potential therapeutic target for the control of vascular complications in diabetes.

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Ultrasound evaluation of subcutaneous and visceral abdominal fat as a predictor of gestational diabetes mellitus: a systematic review

Cited by 7 publications

References 42 publications

Association of body composition in early pregnancy with gestational diabetes mellitus: A meta-analysis

Association of body composition in early pregnancy with gestational diabetes mellitus: A meta-analysis

Association Between Abdominal Adipose Tissue Distribution and Risk of Endometrial Cancer: A Case-Control Study

The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression

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