Ultrasound Evaluation of Site-Specific Effect of Simulated Microgravity on Articular Cartilage

Wang, Qing; Zheng, Yongping; Wang, Xiaoyun; Huang, Y. P.; Liu, Muqing; Wang, Shu-Zhe; Guo, Xia

doi:10.1016/j.ultrasmedbio.2010.04.018

Cited by 17 publications

(22 citation statements)

References 52 publications

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“…Sitedependent variations in the morphologic, acoustic and mechanical properties of articular cartilage have been reported in this study and in earlier studies (Brommer et al 2005;Laasanen et al 2005;Wang et al 2010a), and these findings suggest that articular cartilage functionally adapts to the loading conditions. The articular cartilage at the FC, which is embedded in the acetabulum in the hip joint, is subject to more complicated stresses during various movements (Yoshida et al 2006).…”

Section: Discussionsupporting

confidence: 86%

“…Previous studies have reported that the characteristics of cartilage tissue can be assessed with highfrequency ultrasound. Saarakkala et al (2004) quantified the integrity of the cartilage surface with an ultrasound reflection coefficient (i.e., the spatial variation of the ultrasound reflection coefficient [SVR]) and an ultrasound roughness index (URI) and reported significant decreases in the SVR and increases in the URI of damaged cartilage tissues Wang et al (2010a) reported that a 4-wk tail suspension rat model induced significant decreases in cartilage thickness in the medial femoral condyle and patella and a significant increase in the URI at the patella. Gelse et al (2010) reported that integrated reflection coefficients of repaired cartilage tissue are significantly greater than those of healthy tissue.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative Ultrasound Assessment of Cartilage Degeneration in Ovariectomized Rats with Low Estrogen Levels

Wang

Liu

Wang

et al. 2016

Ultrasound in Medicine & Biology

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Quantitative Ultrasound Assessment of Cartilage Degeneration in Ovariectomized Rats with Low Estrogen Levels

Wang

Liu

Wang

et al. 2016

Ultrasound in Medicine & Biology

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“…High-frequency ultrasound biomicroscopy (UBM) system has been developed for clear imaging of tiny tissues such as articular cartilage [12–17] and cornea [18]. Earlier studies on ultrasonic characteristics of articular cartilage have used echogenicity, sound speed, reflection coefficient, backscatter coefficient, attenuation, and ultrasound roughness index (URI) to reflect the structural and constituent modifications of the tissue.…”

Section: Introductionmentioning

confidence: 99%

“…The tail suspension rat models [17, 23] have been used to investigate space flight-like effects [24] on the body. The aim of this study was to investigate the countermeasure effect of LA on the unloading-induced changes in patellar articular cartilage in tail-suspension rat model using UBM.…”

Section: Introductionmentioning

confidence: 99%

Effect of Laser Acupuncture on Disuse Osteoarthritis: An Ultrasound Biomicroscopic Study of Patellar Articular Cartilage in Rats

Wang

Guo

Liu

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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To investigate the effect of laser acupuncture (LA) on disuse changes in articular cartilage using ultrasound biomicroscopy (UBM), Eighteen rats were randomly divided into the control group (C), the tail-suspended group (T), and the tail-suspended with LA treatment group (L). During 28-day suspension period, group L were treated with LA at acupoints on the left hindlimb while group T had a sham treatment. Ultrasound roughness index (URI), integrated reflection coefficient (IRC), integrated backscatter coefficient (IBC), cartilage thickness, and ultrasonographic score (US) of articular cartilage at patella were measured by using an ultrasound biomicroscopy system (UBS). Compared with the group C, URI significantly (P < 0.01) increased by 60.9% in group T, increased by 38.1% in group L. In addition, unloading induced a significant cartilage thinning (P < 0.05) in group T, whereas cartilage thickness in group L was 140.22 ± 19.61 μm reaching the level of the control group (147.00 ± 23.99 μm). There was no significant difference in IRC, IBC, and US among the three groups. LA therapy could help to retain the quality of articular cartilage which was subjected to unloading. LA would be a simple and safe nonpharmacological countermeasure for unloading-induced osteoarthritis. The UBM system has potential to be a sensitive, specific tool for quantitative assessment of articular cartilage.

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“…Ultrasound technique has been regarded as a potential approach for the study on the swelling behavior of articular cartilage. High frequency focused ultrasound with a high resolution has been applied to monitor relatively small specimens [9,10,26] or small animals [27,28]. Most of those studies are still in a fundamental laboratory level.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Assessment of Boundary Effect on Osmosis-Induced Shrinkage and Swelling of Articular CartilageIn Vitro

Wang

Zheng

2012

Connective Tissue Research

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This study aims to use ultrasound to investigate the boundary effect of the cut edge on the osmosis-induced shrinkage and swelling of articular cartilage while the distance from the scanning site to the edge decreases with the reduction of specimen size. Sixteen cartilage-bone specimens (of diameter 6.35 mm) were prepared from normal bovine patellae. The cartilage width was gradually reduced to 4.35 mm and to 2.35 mm. Shrinkage and swelling were induced by changing the concentration of the saline solution and monitored using nominal 50 MHz focused ultrasound. The parameters including shrinkage and swelling peak strains (ϵ(P1) and ϵ(P2), respectively), shrinkage and swelling equilibrium strains (ϵ(E1) and ϵ(E2), respectively), and shrinkage and swelling slopes (k(1) and k(2), respectively) were extracted. The ϵ(P1), ϵ(E1), ϵ(E2), k(1), and k(2) of the 2.35 mm specimens were significantly different (p < 0.05) from those of the 6.35 mm specimens. For the 4.35 mm specimens, ϵ(E1) and ϵ(P1) were, respectively, significantly different (p < 0.05) from ϵ(E1) of the 6.35 mm specimens and ϵ(P1) of the 2.35 mm specimens. The percentage of coefficient of variation (18.5% for shrinkage and 16.3% for swelling) of the 2.35 mm specimens was much higher than that (<8.5%) of the 6.35 mm specimens. The relative root mean square difference (rRMSD%, 12.0% for shrinkage and 10.6% for swelling) of the 2.35 mm specimens was also much higher than that (<5.5%) of the 6.35 mm specimens. The results indicated that the boundary effect of the cut edge on the osmosis-induced shrinkage and swelling of articular cartilage increases with the reduction of specimen size.

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Ultrasound Evaluation of Site-Specific Effect of Simulated Microgravity on Articular Cartilage

Cited by 17 publications

References 52 publications

Quantitative Ultrasound Assessment of Cartilage Degeneration in Ovariectomized Rats with Low Estrogen Levels

Quantitative Ultrasound Assessment of Cartilage Degeneration in Ovariectomized Rats with Low Estrogen Levels

Effect of Laser Acupuncture on Disuse Osteoarthritis: An Ultrasound Biomicroscopic Study of Patellar Articular Cartilage in Rats

Ultrasound Assessment of Boundary Effect on Osmosis-Induced Shrinkage and Swelling of Articular CartilageIn Vitro

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