Ultrasound-enhanced theranostics of orthotopic breast cancer through a multifunctional core–shell tecto dendrimer-based nanomedicine platform

Abstract

Design of multifunctional nanoplatforms combined with ultrasound-targeted microbubble destruction (UTMD) technology for enhanced tumor accumulation is feasible to solve the bottleneck of theranostics. Herein, we present the development of zwitterion-modified...

Advances in Doxorubicin-based nano-drug delivery system in triple negative breast cancer

“…In vivo experiments demonstrated that when CRD13@DOX was injected intravenously, it could cause CRD13@DOX to accumulate at the site of the lesion and significantly reduce the weight and size of tumors in TNBC mice in vivo . Gong et al ( Gong J et al, 2023 ) constructed a metal dendritic polymer (CSTD) with ß -cyclodextrin and modified Gd(III), co-delivered MicroRNA 21 inhibitor (MiR 21i) and DOX, used ultrasound-enhanced treatment of in situ TNBC model ( Figure 6A ). Its large size of the internal cavity structure allowed DOX to achieve an encapsulation rate of up to 84.0%.…”

“… (A) Schematic diagram of the preparation and evaluation of anti-tumor effects of multifunctional CSTD nano-delivery system ( Gong J et al, 2023 ). Copyright 2023.…”

miRNA-Based Technologies in Cancer Therapy

“…Furthermore, they are characterized by good stability, but they also have disadvantages that involve the uncontrolled release of drugs and toxicity because they have been reported to display cytotoxic and hemolytic activity at elevated concentrations, which excludes their intravenous use in anticancer therapy [215,216]. A reference example of their use is the advanced design of PCSTD-Gd/DOX/miR 21i polyplexes, which improved the combination of chemo-gene treatment guided by MR imaging and was studied on an orthotopic breast cancer model in vivo [217].…”