Ultrasound-enhanced drug delivery for efficient cancer therapy

Larina, Irina V.; Evers, B. Mark; Bartels, C.; Ashitkov, Taras V.; Larin, Kirill V.; Esenaliev, Rinat O.

doi:10.1109/iembs.2002.1136911

Cited by 7 publications

(8 citation statements)

References 6 publications

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“…in the absence of preformed gas bubbles, appear to be effective in nucleating bubble formation that leads to a reduction in the cavitation threshold in water [119][120][121]. For example, polystyrene (PS) nanoparticles decreased the threshold of ultrasound-induced cavitation activity in pure water from about 7.3 bar to less than 5 bar, depending upon the size and concentration [122][123][124]. The threshold decreased with increasing particle concentration, and decreased with decreasing particle size [124].…”

Section: Polymeric Nanoparticles-solid Polymeric Nanoparticles In An mentioning

confidence: 99%

“…It would be very beneficial to know if this phenomenon extends to other types of solid nanoparticles, the mechanisms by which this occurs, and whether such "threshold lowering" also occurs in blood or in intracellular liquids. Polymers commonly used for drug and gene delivery include PS, poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and polyplexes of plasmids and cationic polymers [122][123][124][125][126][127][128][129][130][131][132].…”

Section: Polymeric Nanoparticles-solid Polymeric Nanoparticles In An mentioning

confidence: 99%

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Micelles and nanoparticles for ultrasonic drug and gene delivery

Husseini

Pitt

2008

Advanced Drug Delivery Reviews

423

268

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Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues selectively, thus reducing the agent's side effects on the rest of the body. Ultrasound, traditionally used in diagnostic medicine, is finding a place in drug delivery in connection with these nanoparticles. In addition to their non-invasive nature and the fact that they can be focused on targeted tissues, acoustic waves have been credited with releasing pharmacological agents from nanocarriers, as well as rendering cell membranes more permeable. In this article, we summarize new technologies that combine the use of nanoparticles with acoustic power both in drug and gene delivery. Ultrasonic drug delivery from micelles usually employs polyether block copolymers and has been found effective in vivo for treating tumors. Ultrasound releases drug from micelles, most probably via shear stress and shock waves from the collapse of cavitation bubbles. Liquid emulsions and solid nanoparticles are used with ultrasound to deliver genes in vitro and in vivo. The small packaging allows nanoparticles to extravasate into tumor tissues. Ultrasonic drug and gene delivery from nanocarriers has tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly non-invasive means.

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Section: Polymeric Nanoparticles-solid Polymeric Nanoparticles In An mentioning

confidence: 99%

Section: Polymeric Nanoparticles-solid Polymeric Nanoparticles In An mentioning

confidence: 99%

Micelles and nanoparticles for ultrasonic drug and gene delivery

Husseini

Pitt

2008

Advanced Drug Delivery Reviews

423

268

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“…The paper [20], proposes anti-cancer drug delivery across the physiological barriers by ultrasound cavitation. The paper presents the achievement of complete regression of tumor cells based on ultrasound enhanced drug delivery.…”

Section: Drug Delivery Mechanismsmentioning

confidence: 99%

A Comprehensive Study on Design Trends and Future Scope of Implantable Drug Delivery Systems

Ramesh¹,

Gupta²,

Ahmed³

et al. 2017

IJBSBT

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“…If nanoparticles (i.e., Polystyrene) are present in tumor, the cavitation threshold could be significantly lowered. Smaller particles have more effects on such a reduction in the cavitation threshold at the same concentration [22,70]. However, polystyrene beads have a virtually indefinite lifetime in the body and are not FDA approved.…”

Section: Bubble Cavitationmentioning

confidence: 99%

Ultrasound‐Mediated Drug/Gene Delivery in Solid Tumor Treatment

Zhou¹

2013

Journal of Healthcare Engineering

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Ultrasound is an emerging modality for drug delivery in chemotherapy. This paper reviews this novel technology by first introducing the designs and characteristics of three classes of drug/gene vehicles, microbubble (including nanoemulsion), liposomes, and micelles. In comparison to conventional free drug, the targeted drug-release and delivery through vessel wall and interstitial space to cancerous cells can be activated and enhanced under certain sonication conditions. In the acoustic field, there are several reactions of these drug vehicles, including hyperthermia, bubble cavitation, sonoporation, and sonodynamics, whose physical properties are illustrated for better understanding of this approach. In vitro and in vivo results are summarized, and future directions are discussed. Altogether, ultrasound-mediated drug/gene delivery under imaging guidance provides a promising option in cancer treatment with enhanced agent release and site specificity and reduced toxicity.

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Ultrasound-enhanced drug delivery for efficient cancer therapy

Cited by 7 publications

References 6 publications

Micelles and nanoparticles for ultrasonic drug and gene delivery

Micelles and nanoparticles for ultrasonic drug and gene delivery

A Comprehensive Study on Design Trends and Future Scope of Implantable Drug Delivery Systems

Ultrasound‐Mediated Drug/Gene Delivery in Solid Tumor Treatment

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