Ultrasound‐Mediated Drug/Gene Delivery in Solid Tumor Treatment

Zhou, Yufeng

doi:10.1260/2040-2295.4.2.223

Cited by 23 publications

(12 citation statements)

References 105 publications

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“…But, it was effectively released into tumor after acoustic radiation, which resulted in effective tumor regression [ 38 , 57 ]. The interaction of ultrasonic pulse with a payload containing microbubbles involves a number of mechanisms, such as acoustic cavitation, heating, radiation forces, and sonoporation [ 58 ]. Stable bubble cavitation generates strong shear stress close to the bubble surface, sufficient to shear cell membranes.…”

Section: Applicationsmentioning

confidence: 99%

Application of acoustic droplet vaporization in ultrasound therapy

Zhou

2015

J Ther Ultrasound

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Microbubbles have been used widely both in the ultrasonic diagnosis to enhance the contrast of vasculature and in ultrasound therapy to increase the bioeffects induced by bubble cavitation. However, due to their large size, the lifetime of microbubbles in the circulation system is on the order of minutes, and they cannot penetrate through the endothelial gap to enter the tumor. In an acoustic field, liquefied gas nanoparticles may be able to change the state and become the gas form in a few cycles of exposure without significant heating effects. Such a phenomenon is called as acoustic droplet vaporization (ADV). This review is intended to introduce the emerging application of ADV. The physics and the theoretical model behind it are introduced for further understanding of the mechanisms. Current manufacturing approaches are provided, and their differences are compared. Based on the characteristic of phase shift, a variety of therapeutic applications have been carried out both in vitro and in vivo. The latest progress and interesting results of vessel occlusion, thermal ablation using high-intensity focused ultrasound (HIFU), localized drug delivery to the tumor and cerebral tissue through the blood-brain barrier, localized tissue erosion by histotripsy are summarized. ADV may be able to overcome some limitations of microbubble-mediated ultrasound therapy and provide a novel drug and molecular targeting carrier. More investigation will help progress this technology forward for clinical translation.

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Section: Applicationsmentioning

confidence: 99%

Application of acoustic droplet vaporization in ultrasound therapy

Zhou

2015

J Ther Ultrasound

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“…The use of ultrasound energy to enhance efficiency of chemotherapy to tumors began as early as the 1970s (Frenkel 2008, Zhou 2013). The cytotoxic effect of nitrogen mustard on mouse leukemia L1210 cells after sonication without any mechanical damage to cells was observed (Kremkau et al 1976).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Small Molecule Delivery by Pulsed High-Intensity Focused Ultrasound: A Parameter Exploration

Zhou

Wang

Farr

et al. 2016

Ultrasound in Medicine & Biology

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Chemotherapeutic drug delivery is often ineffective within solid tumors, but increasing the drug dose would result in systemic toxicity. The use of high-intensity focused ultrasound (HIFU) has the potential to enhance penetration of small molecules. However, operation parameters need to be optimized before the use of chemotherapeutic drug in vivo and translation to clinical trial. In this study, the effects of pulsed-HIFU (pHIFU) parameters (spatial-average pulse-average intensity, duty factor, and pulse repetition frequency) to the penetration as well as content of small molecules were evaluated in ex vivo porcine kidneys. Specific HIFU parameters resulted in over 40 times greater Evans blue content and 3.5 times the penetration depth compared to untreated samples. When selected parameters were applied to porcine kidneys in vivo, a 2.3-fold increase in concentration was obtained after a 2-minute pHIFU exposure. Altogether, pHIFU has shown to be an effective modality to enhance both the concentration and penetration depth of small molecules into tissue using the optimized HIFU parameters. Although, performed in normal tissue, this study has the promise of translation into tumor tissue.

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“…Endothelial junctions of blood vessels in normal tissues are extremely small and measure approximately 7 nm, whereas tumor endothelial pores for most tumor types range from 100 nm to 780 nm, allowing nanocarriers to enter only diseased tissues, which increases the bioavailability of the drug in the tumor. 17 Zhou 18 evaluated the efficiency of chemotherapeutic agents combined with nanoparticles injected in tumor cells and activated with ultrasound. This study demonstrated efficient tumor growth reduction and complete elimination after 2 months.…”

Section: Applicationsmentioning

confidence: 99%

“…18 Treatment with chemotherapeutic agents alone exhibited necrotic regions within the tumor, whereas chemotherapeutics coupled with ultrasound energy demonstrated dramatic tissue necrosis. 18 Ranjan et al 19 studied the effects of free chemotherapeutic agents (Doxorubicin) compared with drug-encapsulated low temperature sensitive liposomes (LTSLs) on rabbits with thigh muscle tumors. The LTSLs revealed a 7.6-fold greater tumor drug delivery compared with the free Doxorubicin 19 (Figure 4).…”

Section: Applicationsmentioning

confidence: 99%

Using High-Intensity Focused Ultrasound as a Means to Provide Targeted Drug Delivery

McClure

2016

Journal of Diagnostic Medical Sonography

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Cancer is a prevalent condition affecting millions of individuals worldwide. According to the United Kingdom's Cancer Research Center, 1 there are more than 200 different forms of cancer. Many patients living with cancer are not eligible for certain forms of treatment due to tumor size, location, and multi-focality or multi-centricity. 2 A highintensity focused ultrasound (HIFU)-mediated drug delivery system, or sonophoresis, has the capability to provide patients with a potential alternative. 3 This novel approach provides patients with a targeted noninvasive treatment option for a variety of different cancers as well as other disorders. 3 Sonophoresis is a process that can accelerate the absorption of a localized treatment compared to other types of cancer treatments that are more invasive or damaging to the patient. 3 This technique is considered a form of HIFU. Cancer is a devastating disease that can oftentimes ravish the body. Management of cancer often involves harsh treatment options over the course of several months or years. A clear issue with cancer treatment is the use of aggressive chemicals and radiation. One of the shortcomings is the lack of targeting, which results in several undesirable side effects for many patients. Those who receive chemotherapy can sometimes find it difficult to attend work and live normally. According to the World Health Organization 4 (WHO), cancer rates are on a steep incline, and it is predicted that approximately 15 million new cases of cancer will be reported by the year 2020. The average of all cancer survival rates is approximately 50%; therefore, finding different treatment options is crucial. 5 The most popular forms of treatment for cancer are chemotherapy, radiation, and surgery. These treatment options prove to be painful and uncomfortable for the patient for long durations. Some forms of treatment are limited because of tumor specifics. 2 Efforts are being made to reduce doselimiting toxicity and improve localized drug delivery. High-intensity focused ultrasound-mediated drug delivery could provide a noninvasive and safe approach to treating a variety of cancers within the body.

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Ultrasound‐Mediated Drug/Gene Delivery in Solid Tumor Treatment

Cited by 23 publications

References 105 publications

Application of acoustic droplet vaporization in ultrasound therapy

Application of acoustic droplet vaporization in ultrasound therapy

Enhancement of Small Molecule Delivery by Pulsed High-Intensity Focused Ultrasound: A Parameter Exploration

Using High-Intensity Focused Ultrasound as a Means to Provide Targeted Drug Delivery

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