Ultrasound Elastography Used for Preventive Non-Invasive Screening in Early Detection of Liver Fibrosis

Bert, F; Stahmeyer, Jona T.; Rossol, S.

doi:10.14740/jocmr2625w

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…Liver elasticity (i.e., elastic modulus) generally increases as scar replaces normal tissue. Elasticity can be probed non-invasively using a number of image-based techniques [4][5][6][7][8][9][10][11][12][13]. Thus, there is the potential to replace serial biopsy with noninvasive elastography to monitor liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Limitations and artifacts in shear-wave elastography of the liver

et al. 2017

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Recent studies have shown that real-time, twodimensional shear-wave elastography (2D-SWE) can monitor liver fibrosis by measuring tissue elasticity (i.e., elastic modulus). Two clinical studies of 2D-SWE in the liver have shown that there are several practical issues that can compromise quantitation of liver tissue elasticity. Both general ultrasound (US) limitations and limitations in the 2D-SWE method itself resulted in significant variability in estimated liver elasticity. The most common US limitations were: poor acoustic window, limited penetration, and rib/ lung shadows. The most common 2D-SWE limitations were: reverberations under the liver capsule, respiratory/cardiac motion, and vessel pulsation/loss of SWE signal. Based on these studies, scan protocols have been optimized to minimize the influence of these limitations on liver elasticity quantification. These refined protocols should move non-invasive SWE closer to becoming the preferred tool to diagnose and manage many chronic diseases of the liver.

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Section: Introductionmentioning

confidence: 99%

Limitations and artifacts in shear-wave elastography of the liver

et al. 2017

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“…Results of these methods that were predictive for various fibrosis stages were correlated to the histological classification of METAVIR (F0-4) based on published literature (METAVIR, LF stages F0-1: F0: no fibrosis; F1: portal fibrosis without septa; F2: few septa; F3: numerous septa without cirrhosis; F4: cirrhosis) [ 25 - 27 ].…”

Section: Methodsmentioning

confidence: 99%

Non-Invasive Reliable Methods to Objectify the Positive Influence of Hepatitis C Virus Treatment on Liver Stiffness

et al. 2021

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Background Chronic active hepatitis C virus (HCV) infection is a major public health problem and causes liver fibrosis (LF) up to liver cirrhosis (LC). LF can be estimated by non-invasive, easy handling methods. With implementation of new HCV therapies, elimination rates of HCV are near 100%, resulting in less clinical complications and costs. The aim of our study was to evaluate the positive influence of HCV treatment on liver stiffness by non-invasive assessments of LF. Methods Sixty-two patients with HCV were treated with antiviral drug regimes. Serological fibrosis scores and ultrasound elastography (acoustic radiation force impulse and shear wave elasticity imaging (ARFI-SWEI)) were used for LF assessment on day 0 and 6 months after therapy. Results Antiviral treatment was successful in all cases. ARFI-SWEI measurements showed an improvement of all LF stages. Results of serological markers and scores were heterogeneous. Significant positive effects of treatment were seen for aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 (FIB-4) scores, only. Further Pearson’s coefficient showed moderate till very high correlations for ARFI-SWEI and FIB-4/APRI scores. Conclusion Today HCV therapy is able to cure HCV. Positive influences are improvement of LF stages. ARFI-SWEI, APRI and FIB-4 score are useful, easy handling tools to verify positive influence of HCV treatment on LF alone or in combination.

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“…pSWE can be used in HBV, HCV, hepatic toxicity, alcoholic liver disease, and autoimmune hepatitis related liver fibrosis[37–39]. It can also be used as a screening tool for fibrosis detection at early stages[40], although evidence of benefit in this setting is limited. pSWE has been shown to be useful in detection of liver fibrosis.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Principles of ultrasound elastography

et al. 2018

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Tissue stiffness has long been known to be a biomarker of tissue pathology. Ultrasound elastography measures tissue mechanical properties by monitoring the response of tissue to acoustic energy. Different elastographic techniques have been applied to many different tissues and diseases. Depending on the pathology, patient-based factors, and ultrasound operator-based factors, these techniques vary in accuracy and reliability. In this review, we discuss the physical principles of ultrasound elastography, discuss differences between different ultrasound elastographic techniques, and review the advantages and disadvantages of these techniques in clinical practice.

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Ultrasound Elastography Used for Preventive Non-Invasive Screening in Early Detection of Liver Fibrosis

Cited by 7 publications

References 24 publications

Limitations and artifacts in shear-wave elastography of the liver

Limitations and artifacts in shear-wave elastography of the liver

Non-Invasive Reliable Methods to Objectify the Positive Influence of Hepatitis C Virus Treatment on Liver Stiffness

Principles of ultrasound elastography

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