Ultrasound elastography for carpal tunnel pressure measurement: A cadaveric validation study

Kubo, Kazutoshi; Zhou, Boran; Cheng, Yu-Shiuan; Yang, Tai-Hua; Qiang, Boqin; An, Kai Nan; Moran, Steven L.; Amadio, Peter C.; Zhang, Xiao Ming; Zhao, Chunfeng

doi:10.1002/jor.23658

Cited by 38 publications

(24 citation statements)

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“…C, Demonstrates increased median nerve stiffness in mild carpal tunnel syndrome, which is further increased in severe carpal tunnel syndrome (D). D, Note that in severe carpal tunnel syndrome there is an increase in the stiffness of all of the contents of the carpal tunnel, which correlates with increasing carpal tunnel pressure 70 where G is shear modulus, ρ is tissue density (ffi1000 kg/m 3 ) and c is SWV. Tissue density will vary for different types of soft tissues.…”

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confidence: 99%

Ultrasound elastography for the evaluation of peripheral nerves: A systematic review

Wee

Simon

2019

Muscle and Nerve

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Peripheral nerve disorders are commonly encountered in clinical practice. Electrodiagnostic studies remain the cornerstone of the evaluation of nerve disorders. More recently, ultrasound has played an increasing complementary role in the neuromuscular clinic. Ultrasound elastography is a technique that measures the elastic properties of tissues. Given the histological changes that occur in diseased peripheral nerves, nerve ultrasound elastography has been explored as a noninvasive way to evaluate changes in nerve tissue composition. Studies to date suggest that nerve stiffness tends to increase in the setting of peripheral neuropathy, regardless of etiology, consistent with loss of more compliant myelin, and replacement with connective tissue. The aim of this systematic review is to summarize the current literature on the use of ultrasound elastography in the evaluation of peripheral neuropathy. Limitations of ultrasound elastography and gaps in current literature are discussed, and prospects for future clinical and research applications are raised.

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confidence: 99%

Ultrasound elastography for the evaluation of peripheral nerves: A systematic review

Wee

Simon

2019

Muscle and Nerve

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“…Previous publications have described the potential of elastography for CTS, with the majority reporting increased nerve stiffness (ratios) in patients with CTS 20–32 ; three research studies reported no significant difference 33–35 . In addition, US elastography has been used to assess carpal ligament stiffness, 36,37 intra carpal tunnel pressure, 38,39 the correlation between median nerve area and strain 40 and the difference in median nerve elasticity before and after carpal tunnel release 41 . These studies support the notion that the nerve's mechanical properties change in CTS patients, but the majority used strain elastography with manual compression to induce the tissue strain.…”

Section: Introductionmentioning

confidence: 73%

Shear wave elastography of the median nerve: A mechanical study

et al. 2020

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Background: Shear wave elastography (SWE) shows promise in peripheral neuropathy evaluation but has potential limitations due to tissue size and heterogeneity. We tested SWE sensitivity to elasticity change and the effect of probe position in a median nerve cadaver model. Methods: Ten specimens were used to measure median nerve elasticity under increasing loads using SWE and indentation. Measurements were compared using repeated-measures analysis of variance. Results: Indentation and SWE-based longitudinal nerve elasticity increased with tensile loading (P < .01), showing a similar relationship. Acquisition in a transverse plane showed lower values compared with longitudinal measurements, mostly under higher loads (P = .03), as did postdissection elasticity (P = .02). Elasticity did not change when measured proximal to the carpal tunnel. Conclusions: Longitudinal SWE is sensitive to changes in median nerve elasticity. Measuring elasticity of peripheral nerves noninvasively could elucidate intra-neural pathology related to compression neuropathies, and proof to be of added value as a diagnostic or prognostic tool. K E Y W O R D S carpal tunnel syndrome, elastography, nerve elasticity, neurodynamics, peripheral neuropathy

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“…The softening of the traction-separation relationship is attributed to the softening behavior of the medial interfacial strength, plaque, or fibrous cap [28][29][30]. Hence, these CZMs are able to characterize the mechanical response of the cohesive element during the crack propagation.…”

Section: Effects and Features Of Four Shapes Of Czms In Simulating Thmentioning

confidence: 99%

A comparative study of cohesive zone models for predicting delamination fracture behaviors of arterial wall

et al. 2020

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Arterial tissue delamination, manifested as the fracture failure between arterial layers, is an important process of the atherosclerotic plaque rupture, leading to potential life-threatening clinical consequences. Numerous models have been used to characterize the arterial tissue delamination fracture failure. However, only a few have investigated the effect of cohesive zone model (CZM) shapes on predicting the delamination behavior of the arterial wall. In this study, four types of CZMs (triangular, trapezoidal, linear–exponential, and exponential–linear) were investigated to compare their prediction of the arterial wall fracture failure. The Holzapfel–Gasser–Ogden (HGO) model was adopted for modeling the mechanical behavior of the aortic bulk material. The CZMs optimized during the comparison of the aortic media delamination simulations were also used to perform the comparative study of the mouse plaque delamination and human fibrous cap delamination. The results show that: (1) the numerical predicted the relationships of force–displacement in the delamination behaviors based on the triangular, trapezoidal, linear–exponential, and exponential–linear CZMs match well with the experimental measurements. (2) The traction–separation relationship results simulated by the four types of CZMs could react well as the corresponding CZM shapes. (3) The predicted load–load point displacement curves using the triangular and exponential–linear CZMs are in good agreement with the experimental data, relative to the other two shapes of CZMs. All these provide a new method combined with the factor of shape in the cohesive models to simulate the crack propagation behaviors and can capture the arterial tissue failure response well.

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Ultrasound elastography for carpal tunnel pressure measurement: A cadaveric validation study

Cited by 38 publications

References 50 publications

Ultrasound elastography for the evaluation of peripheral nerves: A systematic review

Ultrasound elastography for the evaluation of peripheral nerves: A systematic review

Shear wave elastography of the median nerve: A mechanical study

A comparative study of cohesive zone models for predicting delamination fracture behaviors of arterial wall

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