Ultrasound combined with microbubbles enhances the renoprotective effects of methylprednisolone in rats with adriamycin-induced nephropathy

Ren, Shuting; Si, Ruoyan; Sun, Pengfei; Wu, Tieqiao; Dai, Aozhi; Chen, Lina; Zhao, Wenbao; Han, Tao; Zhang, Xin; Chai, Zhonglin

doi:10.1016/j.ejps.2021.105714

Cited by 4 publications

(1 citation statement)

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“…Systemic administration faces the constraint of the BBB, overall biodistribution and clearance from the body [ 52 , 56 ]. To overcome such limits, techniques such as aortic injection and the enhanced permeation of the BBB by differential osmotic pressure [ 19 ] and cavitation generated by a high intensity ultrasound combined with the intravenous administration of microbubbles [ 58 , 59 , 60 ], have been investigated ( Figure 2 A). Although these techniques have the potential to increase the diffusion of active compounds, the accumulation into the desired site could be compromised, while at the same time the clearance from the CNS tissues and circulating blood is held.…”

Section: Routes Of Administration Of Active Pharmaceutical Ingredient...mentioning

confidence: 99%

Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders

Djoudi

Molina-Peña²,

Ferreira³

et al. 2022

IJMS

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Hyaluronic acid (HA) is a Glycosaminoglycan made of disaccharide units containing N-acetyl-D-glucosamine and glucuronic acid. Its molecular mass can reach 10 MDa and its physiological properties depend on its polymeric property, polyelectrolyte feature and viscous nature. HA is a ubiquitous compound found in almost all biological tissues and fluids. So far, HA grades are produced by biotechnology processes, while in the human organism it is a major component of the extracellular matrix (ECM) in brain tissue, synovial fluid, vitreous humor, cartilage and skin. Indeed, HA is capable of forming hydrogels, polymer crosslinked networks that are very hygroscopic. Based on these considerations, we propose an overview of HA-based scaffolds developed for brain cancer treatment, central and peripheral nervous systems, discuss their relevance and identify the most successful developed systems.

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